Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection

• Published in: Journal of pineal research Vol. 63; no. 1
• Main Authors: Brazão, Vânia, Santello, Fabricia H., Colato, Rafaela P., Mazotti, Tamires T., Tazinafo, Lucas F., Toldo, Míriam Paula A., Vale, Gabriel T., Tirapelli, Carlos R., Prado, José C.
• Format: Journal Article
• Language: English
• Published: England 01.08.2017
• Subjects: Aging; Animals; antioxidant protection; Antioxidants - pharmacology; CD28 Antigens - metabolism; Chagas Disease - immunology; Chagas Disease - metabolism; immune response; Macrophages, Peritoneal - drug effects; Male; melatonin; Melatonin - pharmacology; Oxidative Stress - drug effects; Oxidoreductases - metabolism; Rats; Rats, Wistar; Trypanosoma cruzi; melatonin; immune response; antioxidant protection; Trypanosoma cruzi

The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase—SOD and reduced glutathione levels (GSH) to understand whether age‐related changes would influence the de...