Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection
The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase—SOD and reduced glutathione levels (GSH) to understand whether age‐related changes would influence the de...
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| Published in | Journal of pineal research Vol. 63; no. 1 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.08.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase—SOD and reduced glutathione levels (GSH) to understand whether age‐related changes would influence the development of acute Trypanosoma cruzi (T. cruzi) infection. Young‐ (5 weeks) and middle‐aged (18 months) Wistar rats were orally treated with melatonin (gavage) (05 mg/kg/day), 9 days after infection. A significant increase in both SOD activity and GSH levels was found in plasma from all middle‐aged melatonin‐treated animals. Melatonin triggered enhanced expression of major histocompatibility class II (MHC‐II) antigens on antigen‐presenting cell (APC) and peritoneal macrophages in all treated animals. High levels of CD4+CD28‐negative T cells (*P<.05) were detected in middle‐aged control animals. Melatonin induced a significant reduction (***P<.001) in CD28‐negative in CD4+ and CD8+ T cells in middle‐aged control animals. Contrarily, the same group displayed upregulated CD4+CD28+T and CD8+CD28+T cells. Melatonin also triggered an upregulation of CD80 and CD86 expression in all young‐treated groups. Significant percentages of B and spleen dendritic cells in middle‐aged infected and treated animals were observed. Our data reveal new features of melatonin action in inhibiting membrane lipid peroxidation, through the reduction in 8‐isoprostane, upregulating the antioxidant defenses and triggering an effective balance in the antioxidant/oxidant status during acute infection. The ability of melatonin to counteract the immune alterations induced by aging added further support to its use as a potential therapeutic target not only for T. cruzi infection but also for other immunocompromised states. |
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| AbstractList | The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase-SOD and reduced glutathione levels (GSH) to understand whether age-related changes would influence the development of acute Trypanosoma cruzi (T. cruzi) infection. Young- (5 weeks) and middle-aged (18 months) Wistar rats were orally treated with melatonin (gavage) (05 mg/kg/day), 9 days after infection. A significant increase in both SOD activity and GSH levels was found in plasma from all middle-aged melatonin-treated animals. Melatonin triggered enhanced expression of major histocompatibility class II (MHC-II) antigens on antigen-presenting cell (APC) and peritoneal macrophages in all treated animals. High levels of CD4
CD28-negative T cells (*P<.05) were detected in middle-aged control animals. Melatonin induced a significant reduction (***P<.001) in CD28-negative in CD4
and CD8
T cells in middle-aged control animals. Contrarily, the same group displayed upregulated CD4
CD28
T and CD8
CD28
T cells. Melatonin also triggered an upregulation of CD80 and CD86 expression in all young-treated groups. Significant percentages of B and spleen dendritic cells in middle-aged infected and treated animals were observed. Our data reveal new features of melatonin action in inhibiting membrane lipid peroxidation, through the reduction in 8-isoprostane, upregulating the antioxidant defenses and triggering an effective balance in the antioxidant/oxidant status during acute infection. The ability of melatonin to counteract the immune alterations induced by aging added further support to its use as a potential therapeutic target not only for T. cruzi infection but also for other immunocompromised states. The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase—SOD and reduced glutathione levels (GSH) to understand whether age‐related changes would influence the development of acute Trypanosoma cruzi (T. cruzi) infection. Young‐ (5 weeks) and middle‐aged (18 months) Wistar rats were orally treated with melatonin (gavage) (05 mg/kg/day), 9 days after infection. A significant increase in both SOD activity and GSH levels was found in plasma from all middle‐aged melatonin‐treated animals. Melatonin triggered enhanced expression of major histocompatibility class II (MHC‐II) antigens on antigen‐presenting cell (APC) and peritoneal macrophages in all treated animals. High levels of CD4+CD28‐negative T cells (*P<.05) were detected in middle‐aged control animals. Melatonin induced a significant reduction (***P<.001) in CD28‐negative in CD4+ and CD8+ T cells in middle‐aged control animals. Contrarily, the same group displayed upregulated CD4+CD28+T and CD8+CD28+T cells. Melatonin also triggered an upregulation of CD80 and CD86 expression in all young‐treated groups. Significant percentages of B and spleen dendritic cells in middle‐aged infected and treated animals were observed. Our data reveal new features of melatonin action in inhibiting membrane lipid peroxidation, through the reduction in 8‐isoprostane, upregulating the antioxidant defenses and triggering an effective balance in the antioxidant/oxidant status during acute infection. The ability of melatonin to counteract the immune alterations induced by aging added further support to its use as a potential therapeutic target not only for T. cruzi infection but also for other immunocompromised states. The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase-SOD and reduced glutathione levels (GSH) to understand whether age-related changes would influence the development of acute Trypanosoma cruzi (T. cruzi) infection. Young- (5 weeks) and middle-aged (18 months) Wistar rats were orally treated with melatonin (gavage) (05 mg/kg/day), 9 days after infection. A significant increase in both SOD activity and GSH levels was found in plasma from all middle-aged melatonin-treated animals. Melatonin triggered enhanced expression of major histocompatibility class II (MHC-II) antigens on antigen-presenting cell (APC) and peritoneal macrophages in all treated animals. High levels of CD4+ CD28-negative T cells (*P<.05) were detected in middle-aged control animals. Melatonin induced a significant reduction (***P<.001) in CD28-negative in CD4+ and CD8+ T cells in middle-aged control animals. Contrarily, the same group displayed upregulated CD4+ CD28+ T and CD8+ CD28+ T cells. Melatonin also triggered an upregulation of CD80 and CD86 expression in all young-treated groups. Significant percentages of B and spleen dendritic cells in middle-aged infected and treated animals were observed. Our data reveal new features of melatonin action in inhibiting membrane lipid peroxidation, through the reduction in 8-isoprostane, upregulating the antioxidant defenses and triggering an effective balance in the antioxidant/oxidant status during acute infection. The ability of melatonin to counteract the immune alterations induced by aging added further support to its use as a potential therapeutic target not only for T. cruzi infection but also for other immunocompromised states. The purpose of this study was to investigate the effects of melatonin on selected biomarkers of innate and humoral immune response as well as the antioxidant/oxidant status (superoxide dismutase— SOD and reduced glutathione levels ( GSH ) to understand whether age‐related changes would influence the development of acute Trypanosoma cruzi (T. cruzi) infection. Young‐ (5 weeks) and middle‐aged (18 months) Wistar rats were orally treated with melatonin (gavage) (05 mg/kg/day), 9 days after infection. A significant increase in both SOD activity and GSH levels was found in plasma from all middle‐aged melatonin‐treated animals. Melatonin triggered enhanced expression of major histocompatibility class II ( MHC ‐ II ) antigens on antigen‐presenting cell ( APC ) and peritoneal macrophages in all treated animals. High levels of CD 4 + CD 28‐negative T cells (* P <.05) were detected in middle‐aged control animals. Melatonin induced a significant reduction (*** P <.001) in CD 28 ‐ negative in CD 4 + and CD 8 + T cells in middle‐aged control animals. Contrarily, the same group displayed upregulated CD 4 + CD 28 + T and CD 8 + CD 28 + T cells. Melatonin also triggered an upregulation of CD 80 and CD 86 expression in all young‐treated groups. Significant percentages of B and spleen dendritic cells in middle‐aged infected and treated animals were observed. Our data reveal new features of melatonin action in inhibiting membrane lipid peroxidation, through the reduction in 8‐isoprostane, upregulating the antioxidant defenses and triggering an effective balance in the antioxidant/oxidant status during acute infection. The ability of melatonin to counteract the immune alterations induced by aging added further support to its use as a potential therapeutic target not only for T. cruzi infection but also for other immunocompromised states. |
| Author | Santello, Fabricia H. Mazotti, Tamires T. Tazinafo, Lucas F. Vale, Gabriel T. Prado, José C. Toldo, Míriam Paula A. Brazão, Vânia Tirapelli, Carlos R. Colato, Rafaela P. |
| Author_xml | – sequence: 1 givenname: Vânia orcidid: 0000-0003-0149-4957 surname: Brazão fullname: Brazão, Vânia email: vaniabrazao@gmail.com organization: University of São Paulo – sequence: 2 givenname: Fabricia H. surname: Santello fullname: Santello, Fabricia H. organization: University of São Paulo – sequence: 3 givenname: Rafaela P. surname: Colato fullname: Colato, Rafaela P. organization: University of São Paulo – sequence: 4 givenname: Tamires T. surname: Mazotti fullname: Mazotti, Tamires T. organization: University of São Paulo – sequence: 5 givenname: Lucas F. surname: Tazinafo fullname: Tazinafo, Lucas F. organization: University of São Paulo – sequence: 6 givenname: Míriam Paula A. surname: Toldo fullname: Toldo, Míriam Paula A. organization: University of São Paulo – sequence: 7 givenname: Gabriel T. surname: Vale fullname: Vale, Gabriel T. organization: USP – sequence: 8 givenname: Carlos R. surname: Tirapelli fullname: Tirapelli, Carlos R. organization: USP – sequence: 9 givenname: José C. surname: Prado fullname: Prado, José C. organization: University of São Paulo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28370218$$D View this record in MEDLINE/PubMed |
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| Copyright | 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
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| Keywords | melatonin immune response antioxidant protection Trypanosoma cruzi |
| Language | English |
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| PublicationYear | 2017 |
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| SubjectTerms | Aging Animals antioxidant protection Antioxidants - pharmacology CD28 Antigens - metabolism Chagas Disease - immunology Chagas Disease - metabolism immune response Macrophages, Peritoneal - drug effects Male melatonin Melatonin - pharmacology Oxidative Stress - drug effects Oxidoreductases - metabolism Rats Rats, Wistar Trypanosoma cruzi |
| Title | Melatonin: Antioxidant and modulatory properties in age‐related changes during Trypanosoma cruzi infection |
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