Metformin in the first trimester and risks for specific birth defects in the National Birth Defects Prevention Study

• Published in: Birth defects research Vol. 110; no. 7; p. 579
• Main Authors: Dukhovny, Stephanie, Van Bennekom, Carla M, Gagnon, David R, Hernandez Diaz, Sonia, Parker, Samantha E, Anderka, Marlene, Werler, Martha M, Mitchell, Allen A
• Format: Journal Article
• Language: English
• Published: United States 17.04.2018
• Subjects: Abnormalities, Drug-Induced - prevention & control; Adult; Female; Humans; Hypoglycemic Agents - adverse effects; Logistic Models; Metformin - adverse effects; Pregnancy; Pregnancy Trimester, First; Risk; metformin; National Birth Defects Prevention Study; birth defects; diabetes; oral hypoglycemic agents; polycystic ovarian syndrome

We assessed associations between first-trimester metformin use for pregestational diabetes and specific major birth defects. We compared risks associated with first-trimester metformin use by diabetic women to nondiabetic women on no diabetes medication; we calculated crude odds ratios by exact logi...