Daylight photodynamic therapy with methyl aminolevulinate cream is as effective as conventional photodynamic therapy with blue light in the treatment of actinic keratosis: a controlled randomized intra‐individual study

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 34; no. 8; pp. 1730 - 1735
• Main Authors: Assikar, S., Labrunie, A., Kerob, D., Couraud, A., Bédane, C.
• Format: Journal Article
• Language: English
• Published: England 01.08.2020
• Subjects: Aminolevulinic Acid - therapeutic use; Humans; Keratosis, Actinic - drug therapy; Light; Ointments - therapeutic use; Photochemotherapy; Photosensitizing Agents - therapeutic use; Scalp Dermatoses - drug therapy; Treatment Outcome
• DOI: 10.1111/jdv.16208
• ISSN: 0926-9959; 1468-3083

Background We know the efficacy of daylight phototherapy dynamic (DL‐PDT) in the treatment of actinic keratosis (AK). But the almost studies have compared daylight with red light using methyl aminolevulinate cream and not with blue light. PDT with blue light is another conventional PDT that is effective in the treatment of AKs. Objectives The aim of this study is to assess the efficacy and the safety of DL‐PDT vs. PDT in blue light in the treatment of AKs. Methods This randomized, controlled, intra‐individual efficacy and safety study enrolled 26 subjects. AKs on the face/scalp were treated once, with DL‐PDT on one side and c‐PDT on the contralateral side. Primary endpoints for DL‐PDT at week 12 were efficacy with clearance of AKs and safety with assessment of pain. Lesions with complete response 12 weeks after one treatment session were followed until week 24. Results More than 1000 AK were studied. At week 12, the raw number of disappeared AK lesions at 3‐month follow‐up was 19.6 (±6.0) for DL‐PDT and 20.0 (±6.9) for c‐PDT with P = 0.8460 (90.5% vs. 94.2% of AK disappearance, respectively). The response was maintained at 6 months (90.0% and 94.6% of AK reduction, respectively). DL‐PDT was nearly painless than c‐PDT with light blue: 1.2 vs. 5.1, respectively (P < 0.0001). Conclusions Daylight‐PDT seems as effective as c‐PDT with light blue and DL‐PDT is less painful. The response of DL‐PDT was sustainable until 6 months.