Depression polygenic scores are associated with major depressive disorder diagnosis and depressive episode in Mexican adolescents

• Published in: Journal of affective disorders reports Vol. 2; p. 100028
• Main Authors: Rabinowitz, Jill A., Campos, Adrian I., Benjet, Corina, Su, Jinni, Macias-Kauffer, Luis, Méndez, Enrique, Martinez-Levy, Gabriela A., Cruz-Fuentes, Carlos S., Rentería, Miguel E.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.12.2020; Elsevier
• Subjects: Adolescence; Adversity; Depression; Genetics; Mexican; Polygenic risk scores; Polygenic risk scores; Adversity; Adolescence; Depression; Genetics; Mexican

•We examine prediction from a genetic score to depression in Mexican youth.•A polygenic risk score for depression predicted phenotypic depression.•The polygenic risk score accounted for 1.5–2.5% of the variance in depression.•Gene by environment interactions with adversity were not observed. Large-s...