Depression polygenic scores are associated with major depressive disorder diagnosis and depressive episode in Mexican adolescents
•We examine prediction from a genetic score to depression in Mexican youth.•A polygenic risk score for depression predicted phenotypic depression.•The polygenic risk score accounted for 1.5–2.5% of the variance in depression.•Gene by environment interactions with adversity were not observed. Large-s...
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Published in | Journal of affective disorders reports Vol. 2; p. 100028 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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15.12.2020
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Abstract | •We examine prediction from a genetic score to depression in Mexican youth.•A polygenic risk score for depression predicted phenotypic depression.•The polygenic risk score accounted for 1.5–2.5% of the variance in depression.•Gene by environment interactions with adversity were not observed.
Large-scale genome-wide association studies have uncovered genetic variants associated with depression; however, most of this work has been limited to adults of European ancestry. We investigated the ability of depression polygenic risk scores (PRS) to predict both lifetime and past year major depressive disorder (MDD) diagnosis and major depressive episode (MDE) in a sample of adolescents with admixed ancestry from Mexico City, and explored whether adverse life events moderated these relations.
The study sample consisted of adolescents aged 12–17 (N = 1,123) who were interviewed and genotyped as part of a general population survey on adolescent mental health. PRS for depression were derived using summary statistics from a large-scale discovery genome-wide association study conducted on depressive symptoms that included over 800,000 individuals of European ancestry (Howard et al., 2019).
Higher depression PRS were associated with a greater likelihood of both past year MDD and MDE and lifetime MDE, accounting for 1.5–2.5% of the variance in these outcomes. Adversity did not moderate the relationship between depression PRS and lifetime or past year MDD or MDE.
This study is cross-sectional. As such, some participants might have experienced MDD/MDE after the interview. In addition, our sample comprised only Mexican youth and thus, findings may not generalize to other populations.
Our results indicate that depression PRS derived from a European ancestry GWAS are associated with MDD and MDE risk among Mexican adolescents and have the potential to aid in the identification of youth who may be genetically prone to depression. |
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AbstractList | Objective: Large-scale genome-wide association studies have uncovered genetic variants associated with depression; however, most of this work has been limited to adults of European ancestry. We investigated the ability of depression polygenic risk scores (PRS) to predict both lifetime and past year major depressive disorder (MDD) diagnosis and major depressive episode (MDE) in a sample of adolescents with admixed ancestry from Mexico City, and explored whether adverse life events moderated these relations. Methods: The study sample consisted of adolescents aged 12–17 (N = 1,123) who were interviewed and genotyped as part of a general population survey on adolescent mental health. PRS for depression were derived using summary statistics from a large-scale discovery genome-wide association study conducted on depressive symptoms that included over 800,000 individuals of European ancestry (Howard et al., 2019). Results: Higher depression PRS were associated with a greater likelihood of both past year MDD and MDE and lifetime MDE, accounting for 1.5–2.5% of the variance in these outcomes. Adversity did not moderate the relationship between depression PRS and lifetime or past year MDD or MDE. Limitations: This study is cross-sectional. As such, some participants might have experienced MDD/MDE after the interview. In addition, our sample comprised only Mexican youth and thus, findings may not generalize to other populations. Conclusions: Our results indicate that depression PRS derived from a European ancestry GWAS are associated with MDD and MDE risk among Mexican adolescents and have the potential to aid in the identification of youth who may be genetically prone to depression. •We examine prediction from a genetic score to depression in Mexican youth.•A polygenic risk score for depression predicted phenotypic depression.•The polygenic risk score accounted for 1.5–2.5% of the variance in depression.•Gene by environment interactions with adversity were not observed. Large-scale genome-wide association studies have uncovered genetic variants associated with depression; however, most of this work has been limited to adults of European ancestry. We investigated the ability of depression polygenic risk scores (PRS) to predict both lifetime and past year major depressive disorder (MDD) diagnosis and major depressive episode (MDE) in a sample of adolescents with admixed ancestry from Mexico City, and explored whether adverse life events moderated these relations. The study sample consisted of adolescents aged 12–17 (N = 1,123) who were interviewed and genotyped as part of a general population survey on adolescent mental health. PRS for depression were derived using summary statistics from a large-scale discovery genome-wide association study conducted on depressive symptoms that included over 800,000 individuals of European ancestry (Howard et al., 2019). Higher depression PRS were associated with a greater likelihood of both past year MDD and MDE and lifetime MDE, accounting for 1.5–2.5% of the variance in these outcomes. Adversity did not moderate the relationship between depression PRS and lifetime or past year MDD or MDE. This study is cross-sectional. As such, some participants might have experienced MDD/MDE after the interview. In addition, our sample comprised only Mexican youth and thus, findings may not generalize to other populations. Our results indicate that depression PRS derived from a European ancestry GWAS are associated with MDD and MDE risk among Mexican adolescents and have the potential to aid in the identification of youth who may be genetically prone to depression. |
ArticleNumber | 100028 |
Author | Martinez-Levy, Gabriela A. Rabinowitz, Jill A. Rentería, Miguel E. Benjet, Corina Macias-Kauffer, Luis Méndez, Enrique Cruz-Fuentes, Carlos S. Su, Jinni Campos, Adrian I. |
Author_xml | – sequence: 1 givenname: Jill A. surname: Rabinowitz fullname: Rabinowitz, Jill A. organization: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA – sequence: 2 givenname: Adrian I. orcidid: 0000-0003-3468-8619 surname: Campos fullname: Campos, Adrian I. organization: Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane 4006 QLD, Australia – sequence: 3 givenname: Corina surname: Benjet fullname: Benjet, Corina organization: Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñíz”, Mexico City, Mexico – sequence: 4 givenname: Jinni surname: Su fullname: Su, Jinni organization: Department of Psychology, Arizona State University, Tempe, AZ, USA – sequence: 5 givenname: Luis orcidid: 0000-0002-3080-2835 surname: Macias-Kauffer fullname: Macias-Kauffer, Luis organization: Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, Mexico – sequence: 6 givenname: Enrique surname: Méndez fullname: Méndez, Enrique organization: Investigaciones Epidemiológicas y Psicosociales, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñíz”, Mexico City, Mexico – sequence: 7 givenname: Gabriela A. surname: Martinez-Levy fullname: Martinez-Levy, Gabriela A. organization: Departamento de Genética, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñíz”, Mexico City, Mexico – sequence: 8 givenname: Carlos S. surname: Cruz-Fuentes fullname: Cruz-Fuentes, Carlos S. email: cruz@imp.edu.mx organization: Departamento de Genética, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñíz”, Mexico City, Mexico – sequence: 9 givenname: Miguel E. surname: Rentería fullname: Rentería, Miguel E. email: miguel.renteria@qimrberghofer.edu.au organization: Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane 4006 QLD, Australia |
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CitedBy_id | crossref_primary_10_3389_fgene_2022_1000667 crossref_primary_10_1016_j_jaac_2021_03_020 crossref_primary_10_1002_ajmg_b_32864 |
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Keywords | Polygenic risk scores Adversity Adolescence Depression Genetics Mexican |
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Snippet | •We examine prediction from a genetic score to depression in Mexican youth.•A polygenic risk score for depression predicted phenotypic depression.•The... Objective: Large-scale genome-wide association studies have uncovered genetic variants associated with depression; however, most of this work has been limited... |
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SubjectTerms | Adolescence Adversity Depression Genetics Mexican Polygenic risk scores |
Title | Depression polygenic scores are associated with major depressive disorder diagnosis and depressive episode in Mexican adolescents |
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