Estrogen Receptor α Regulates Tripartite Motif–Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 66; no. 1; pp. 163 - 172
• Main Authors: Smith, Siobhán, Ní Gabhann, Joan, McCarthy, Eoghan, Coffey, Barbara, Mahony, Rebecca, Byrne, Jennifer C., Stacey, Kevin, Ball, Elizabeth, Bell, Aubrey, Cunnane, Gaye, Doran, Michele F., Molloy, Eamonn S., Lee, Ruth Z., Harvey, Brian, Kearns, Grainne, Jefferies, Caroline A.
• Format: Journal Article
• Language: English
• Published: United States 01.01.2014
• Subjects: Adult; Autoantigens; Case-Control Studies; Cells, Cultured; Chromatin Immunoprecipitation; Cyclic AMP Response Element Modulator - genetics; Cyclic AMP Response Element Modulator - metabolism; Cytokines - biosynthesis; Estradiol - physiology; Estrogen Receptor alpha - antagonists & inhibitors; Estrogen Receptor alpha - metabolism; Female; Gene Expression Regulation; Humans; Lupus Erythematosus, Systemic - metabolism; Male; Middle Aged; Monocytes - metabolism; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Response Elements - physiology; Ribonucleoproteins - genetics; Ribonucleoproteins - metabolism; Young Adult

Objective To examine the role of 17β‐estradiol in the regulation of the autoantigen tripartite motif–containing protein 21 (TRIM‐21) in patients with systemic lupus erythematosus (SLE). Methods Monocytes isolated from healthy control subjects and patients with SLE were stimulated with 17β‐estradiol...