Skin colonization by Staphylococcus aureus in hemodialysis patients with pruritus and the effect of Staphylococcus aureus‐secreted α‐toxin on filaggrin expression
Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long‐term care facilities, yet its colonization and impact on the skin of hemodialysis (HD) patients have yet to be studied. The aim of the present study was to investigate the colonization of S. aureus on the skin of pr...
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| Published in | Journal of dermatology Vol. 51; no. 10; pp. 1318 - 1328 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.10.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0385-2407 1346-8138 1346-8138 |
| DOI | 10.1111/1346-8138.17326 |
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| Abstract | Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long‐term care facilities, yet its colonization and impact on the skin of hemodialysis (HD) patients have yet to be studied. The aim of the present study was to investigate the colonization of S. aureus on the skin of pruritic and non‐pruritic HD patients, and the influence of S. aureus and S. aureus‐secreted α‐toxin on skin barrier function‐related protein expression. In this study, a higher relative S. aureus count in pruritic HD patients compared to non‐pruritic HD patients and healthy subjects were revealed by real‐time polymerase chain reaction. S. aureus and α‐toxin decreased mRNA and protein expression levels of aryl hydrocarbon receptor (AHR), ovo‐like transcriptional repressor 1 (OVOL1), and filaggrin (FLG) in keratinocytes. In addition, anti‐alpha‐hemolysin (anti‐hla) was used as an α‐toxin neutralizer, and it successfully abrogated S. aureus‐induced AHR, OVOL1, and FLG mRNA and protein expression downregulation. Mechanistically, α‐toxin could decrease FLG activity by preventing the recruitment of AHR to the FLG promoter region. In conclusion, pruritic HD patients had higher S. aureus colonization, with S. aureus‐secreted α‐toxin suppressing FLG expression through the AHR‐FLG axis. |
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| AbstractList | Staphylococcus aureus
(
S. aureus
) commonly reside on human skin in residents in long‐term care facilities, yet its colonization and impact on the skin of hemodialysis (HD) patients have yet to be studied. The aim of the present study was to investigate the colonization of
S. aureus
on the skin of pruritic and non‐pruritic HD patients, and the influence of
S. aureus
and
S. aureus
‐secreted α‐toxin on skin barrier function‐related protein expression. In this study, a higher relative
S. aureus
count in pruritic HD patients compared to non‐pruritic HD patients and healthy subjects were revealed by real‐time polymerase chain reaction.
S. aureus
and α‐toxin decreased mRNA and protein expression levels of aryl hydrocarbon receptor (AHR), ovo‐like transcriptional repressor 1 (OVOL1), and filaggrin (FLG) in keratinocytes. In addition, anti‐alpha‐hemolysin (anti‐hla) was used as an α‐toxin neutralizer, and it successfully abrogated
S. aureus
‐induced AHR, OVOL1, and FLG mRNA and protein expression downregulation. Mechanistically, α‐toxin could decrease FLG activity by preventing the recruitment of AHR to the FLG promoter region. In conclusion, pruritic HD patients had higher
S. aureus
colonization, with
S. aureus
‐secreted α‐toxin suppressing FLG expression through the AHR‐FLG axis. Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long-term care facilities, yet its colonization and impact on the skin of hemodialysis (HD) patients have yet to be studied. The aim of the present study was to investigate the colonization of S. aureus on the skin of pruritic and non-pruritic HD patients, and the influence of S. aureus and S. aureus-secreted α-toxin on skin barrier function-related protein expression. In this study, a higher relative S. aureus count in pruritic HD patients compared to non-pruritic HD patients and healthy subjects were revealed by real-time polymerase chain reaction. S. aureus and α-toxin decreased mRNA and protein expression levels of aryl hydrocarbon receptor (AHR), ovo-like transcriptional repressor 1 (OVOL1), and filaggrin (FLG) in keratinocytes. In addition, anti-alpha-hemolysin (anti-hla) was used as an α-toxin neutralizer, and it successfully abrogated S. aureus-induced AHR, OVOL1, and FLG mRNA and protein expression downregulation. Mechanistically, α-toxin could decrease FLG activity by preventing the recruitment of AHR to the FLG promoter region. In conclusion, pruritic HD patients had higher S. aureus colonization, with S. aureus-secreted α-toxin suppressing FLG expression through the AHR-FLG axis.Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long-term care facilities, yet its colonization and impact on the skin of hemodialysis (HD) patients have yet to be studied. The aim of the present study was to investigate the colonization of S. aureus on the skin of pruritic and non-pruritic HD patients, and the influence of S. aureus and S. aureus-secreted α-toxin on skin barrier function-related protein expression. In this study, a higher relative S. aureus count in pruritic HD patients compared to non-pruritic HD patients and healthy subjects were revealed by real-time polymerase chain reaction. S. aureus and α-toxin decreased mRNA and protein expression levels of aryl hydrocarbon receptor (AHR), ovo-like transcriptional repressor 1 (OVOL1), and filaggrin (FLG) in keratinocytes. In addition, anti-alpha-hemolysin (anti-hla) was used as an α-toxin neutralizer, and it successfully abrogated S. aureus-induced AHR, OVOL1, and FLG mRNA and protein expression downregulation. Mechanistically, α-toxin could decrease FLG activity by preventing the recruitment of AHR to the FLG promoter region. In conclusion, pruritic HD patients had higher S. aureus colonization, with S. aureus-secreted α-toxin suppressing FLG expression through the AHR-FLG axis. Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long‐term care facilities, yet its colonization and impact on the skin of hemodialysis (HD) patients have yet to be studied. The aim of the present study was to investigate the colonization of S. aureus on the skin of pruritic and non‐pruritic HD patients, and the influence of S. aureus and S. aureus‐secreted α‐toxin on skin barrier function‐related protein expression. In this study, a higher relative S. aureus count in pruritic HD patients compared to non‐pruritic HD patients and healthy subjects were revealed by real‐time polymerase chain reaction. S. aureus and α‐toxin decreased mRNA and protein expression levels of aryl hydrocarbon receptor (AHR), ovo‐like transcriptional repressor 1 (OVOL1), and filaggrin (FLG) in keratinocytes. In addition, anti‐alpha‐hemolysin (anti‐hla) was used as an α‐toxin neutralizer, and it successfully abrogated S. aureus‐induced AHR, OVOL1, and FLG mRNA and protein expression downregulation. Mechanistically, α‐toxin could decrease FLG activity by preventing the recruitment of AHR to the FLG promoter region. In conclusion, pruritic HD patients had higher S. aureus colonization, with S. aureus‐secreted α‐toxin suppressing FLG expression through the AHR‐FLG axis. |
| Author | Wu, Cheng‐Ching Chen, Ying‐Jung Tsai, Yen‐Yu Chang, Long‐Sen |
| Author_xml | – sequence: 1 givenname: Yen‐Yu surname: Tsai fullname: Tsai, Yen‐Yu organization: National Sun Yat‐Sen University – sequence: 2 givenname: Ying‐Jung orcidid: 0000-0001-8562-1268 surname: Chen fullname: Chen, Ying‐Jung email: yjchen@kmu.edu.tw organization: Kaohsiung Medical University Hospital – sequence: 3 givenname: Long‐Sen surname: Chang fullname: Chang, Long‐Sen organization: National Sun Yat‐Sen University – sequence: 4 givenname: Cheng‐Ching surname: Wu fullname: Wu, Cheng‐Ching email: maxvic24@gmail.com organization: E‐Da Cancer Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38894607$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3390/toxins10060252 10.1016/j.jdermsci.2018.02.005 10.1038/s41591-021-01256-2 10.3390/tropicalmed6020070 10.5414/CNP66184 10.3390/ijms232112880 10.1111/j.1365-2133.2009.09229.x 10.1177/0269216308101099 10.1016/j.jaip.2023.02.005 10.1038/ki.2013.454 10.1128/CMR.13.1.16 10.1016/j.jdermsci.2015.02.010 10.1016/j.cbi.2021.109395 10.2147/CCID.S135529 10.1016/j.devcel.2014.03.005 10.1186/1471-5945-5-7 10.3390/pathogens11121504 10.3390/toxins5061140 10.3390/jcm9020312 10.1016/j.jaci.2020.04.024 10.1016/j.jid.2017.05.004 10.1111/all.15640 10.1016/j.chom.2021.05.011 10.1016/j.alit.2021.11.006 10.1093/infdis/jiu223 10.1111/hdi.12301 10.2340/00015555-3296 10.1021/acs.langmuir.2c03092 10.1016/j.cyto.2020.155369 10.1111/j.1468-3083.2006.01570.x 10.1038/cddis.2017.322 10.1007/s12272-021-01305-x 10.1159/000519367 10.3390/ijms20215424 10.1007/s00281-013-0394-4 10.23876/j.krcp.2018.37.2.138 10.1242/jcs.033969 10.1128/msphere.00116-22 10.1080/21505594.2021.1878688 10.1007/s11136-016-1340-4 |
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| Keywords | α‐toxin keratinocytes filaggrin Staphylococcus aureus aryl hydrocarbon receptor |
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| References | 2009; 23 2015; 78 2021; 27 2021; 6 2017; 8 2015; 19 2023; 11 2017; 3 2021; 44 2023; 78 2023; 39 2022; 71 2019; 99 2019; 11 2021; 29 2013; 123 2022; 23 2020; 145 2014; 29 2021; 1 2014; 210 2015; 9 2013; 5 2017; 137 2006; 20 2021; 12 2019; 20 2000; 13 2022; 40 2006; 66 2022; 7 2021; 337 2015; 87 2020; 9 2005; 5 2009; 122 2022; 35 2018; 90 2009; 161 2022; 11 2013 2018; 10 2016; 25 2018; 37 e_1_2_9_30_1 e_1_2_9_31_1 Swarna SS (e_1_2_9_36_1) 2019; 11 e_1_2_9_11_1 e_1_2_9_10_1 e_1_2_9_35_1 McKnight G (e_1_2_9_13_1) 2022; 40 e_1_2_9_32_1 e_1_2_9_12_1 e_1_2_9_33_1 e_1_2_9_15_1 e_1_2_9_38_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_17_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_19_1 e_1_2_9_18_1 e_1_2_9_41_1 Bogaard EH (e_1_2_9_20_1) 2013; 123 e_1_2_9_42_1 e_1_2_9_40_1 e_1_2_9_22_1 e_1_2_9_45_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_23_1 e_1_2_9_44_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 Aramwit P (e_1_2_9_34_1) 2015; 9 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
| References_xml | – volume: 78 start-page: 89 year: 2015 end-page: 94 article-title: Recent advances in atopic dermatitis and psoriasis: genetic background, barrier function, and therapeutic targets publication-title: J Dermatol Sci – volume: 10 year: 2018 article-title: toxins and their molecular activity in infectious diseases publication-title: Toxins – volume: 13 start-page: 16 year: 2000 end-page: 34 article-title: Exotoxins of publication-title: Clin Microbiol Rev – volume: 39 start-page: 2347 year: 2023 end-page: 2357 article-title: Solubility of foreign molecules in stratum Corneum brick and mortar structure publication-title: Langmuir – volume: 1 year: 2021 article-title: Elevated interleukin 31 serum levels in hemodialysis patients are associated with uremic pruritus publication-title: Cytokine – volume: 99 start-page: 1201 year: 2019 end-page: 1209 article-title: Skin barrier damage and itch: review of mechanisms, topical management and future directions publication-title: Acta Derm Venereol – volume: 87 start-page: 685 year: 2015 end-page: 691 article-title: Uremic pruritus publication-title: Kidney Int – volume: 20 start-page: 672 year: 2006 end-page: 678 article-title: An epidemiology study of patients with uremic pruritus publication-title: J Eur Acad Dermatol Venereol – volume: 9 year: 2020 article-title: Skin mediates fermentation to suppress the calcium phosphate‐induced itching: a butyric acid derivative with potential for uremic pruritus publication-title: J Clin Med – volume: 23 start-page: 111 year: 2009 end-page: 119 article-title: Symptom burden and quality of life in end‐stage renal disease: a study of 179 patients on dialysis and palliative care publication-title: Palliat Med – volume: 145 start-page: 1517 year: 2020 end-page: 1528 article-title: Environmental factors in epithelial barrier dysfunction publication-title: J Allergy Clin Immunol – volume: 161 start-page: 300 year: 2009 end-page: 305 article-title: Isolation of α‐toxin‐producing from the skin of highly sensitized adult patients with severe atopic dermatitis publication-title: Br J Dermatol – volume: 137 start-page: 2110 year: 2017 end-page: 2119 article-title: Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans publication-title: J Invest Dermatol – volume: 12 start-page: 547 year: 2021 end-page: 569 article-title: Pathogenicity and virulence of publication-title: Virulence – volume: 5 start-page: 1 year: 2005 end-page: 6 article-title: Pruritus in hemodialysis patients publication-title: BMC Dermatol – volume: 44 start-page: 36 year: 2021 end-page: 48 article-title: Skin barrier dysfunction and filaggrin publication-title: Arch Pharm Res – volume: 23 year: 2022 article-title: An inflamed and infected reconstructed human epidermis to study atopic dermatitis and skin care ingredients publication-title: Int J Mol Sci – volume: 11 year: 2019 article-title: Pruritus associated with chronic kidney disease: a comprehensive literature review publication-title: Cureus – volume: 25 start-page: 3097 year: 2016 end-page: 3106 article-title: Health‐related quality of life in haemodialysis patients suffering from chronic itch: results from GEHIS (German epidemiology Haemodialysis itch study) publication-title: Qual Life Res – volume: 35 start-page: 87 year: 2022 end-page: 93 article-title: Skin lesions, skin care, and characteristics of pruritus in patients undergoing haemodialysis publication-title: Skin Pharmacol Physiol – volume: 6 year: 2021 article-title: High prevalence of methicillin‐resistant among healthcare facilities and its related factors in Myanmar (2018–2019) publication-title: Trop Med Infect Dis – volume: 19 start-page: 531 year: 2015 end-page: 535 article-title: Prevalence of uremic itching in patients undergoing hemodialysis publication-title: Hemodial Int – volume: 122 start-page: 1285 year: 2009 end-page: 1294 article-title: Filaggrin in the frontline: role in skin barrier function and disease publication-title: J Cell Sci – volume: 78 start-page: 1292 year: 2023 end-page: 1306 article-title: causes aberrant epidermal lipid composition and skin barrier dysfunction publication-title: Allergy – volume: 71 start-page: 3 year: 2022 end-page: 13 article-title: Skin barrier defects in atopic dermatitis: from old idea to new opportunity publication-title: Allergol Int – volume: 27 start-page: 700 year: 2021 end-page: 709 article-title: Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial publication-title: Nat Med – volume: 8 year: 2017 article-title: Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis publication-title: Cell Death Dis – volume: 337 year: 2021 article-title: Resveratrol inhibits matrix metalloproteinase‐1 and ‐3 expression by suppressing of p300/NFκB acetylation in TNF‐α‐treated human dermal fibroblasts publication-title: Chem Biol Interact – volume: 11 year: 2022 article-title: Characteristics of isolated from patients in Busia County referral hospital, Kenya publication-title: Pathogens – volume: 7 year: 2022 article-title: Comparative genomics identifies features associated with methicillin‐resistant (MRSA) transmission in hospital settings publication-title: Msphere – volume: 5 start-page: 1140 year: 2013 end-page: 1166 article-title: α‐toxin: nearly a century of intrigue publication-title: Toxins – volume: 66 start-page: 184 year: 2006 end-page: 191 article-title: Uremic pruritus is associated with higher kt/V and serum calcium concentration publication-title: Clin Nephrol – volume: 90 start-page: 227 year: 2018 end-page: 231 article-title: The role of the OVOL1–OVOL2 axis in normal and diseased human skin publication-title: J Dermatol Sci – volume: 40 start-page: 8 year: 2022 end-page: 12 article-title: Physiology of the skin publication-title: Surgery – volume: 20 year: 2019 article-title: Aryl hydrocarbon receptor in atopic dermatitis and psoriasis publication-title: Int J Mol Sci – volume: 29 start-page: 47 year: 2014 end-page: 58 article-title: Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells publication-title: Dev Cell – volume: 9 start-page: 19 year: 2015 end-page: 41 article-title: Uremic pruritus; its prevalence, pathophysiology and management publication-title: Intech Open Sci – volume: 37 start-page: 138 year: 2018 end-page: 147 article-title: Uremic pruritus and associated factors in hemodialysis patients: a multi‐center study publication-title: Kidney Res Clin Pract – volume: 210 start-page: 1012 year: 2014 end-page: 1018 article-title: Targeting α‐toxin as a novel approach to reduce severity of recurrent skin and soft‐tissue infections publication-title: J Infect Dis – volume: 123 start-page: 917 year: 2013 end-page: 927 article-title: Coal tar induces AHR‐dependent skin barrier repair in atopic dermatitis publication-title: J Clin Invest – volume: 11 start-page: 1335 year: 2023 end-page: 1346 article-title: Targeting skin barrier function in atopic dermatitis publication-title: J Allergy Clin Immunol Pract – volume: 29 start-page: 1235 year: 2021 end-page: 1248 article-title: Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor publication-title: Cell Host Microbe – volume: 3 start-page: 249 year: 2017 end-page: 257 article-title: Effect of a lotion containing the heat‐treated probiotic strain NCC 533 on colonization in atopic dermatitis publication-title: Clin Cosmet Investig Dermatol – year: 2013 – ident: e_1_2_9_8_1 doi: 10.3390/toxins10060252 – volume: 9 start-page: 19 year: 2015 ident: e_1_2_9_34_1 article-title: Uremic pruritus; its prevalence, pathophysiology and management publication-title: Intech Open Sci – ident: e_1_2_9_22_1 doi: 10.1016/j.jdermsci.2018.02.005 – ident: e_1_2_9_42_1 doi: 10.1038/s41591-021-01256-2 – ident: e_1_2_9_6_1 doi: 10.3390/tropicalmed6020070 – ident: e_1_2_9_28_1 doi: 10.5414/CNP66184 – ident: e_1_2_9_25_1 doi: 10.3390/ijms232112880 – ident: e_1_2_9_10_1 doi: 10.1111/j.1365-2133.2009.09229.x – ident: e_1_2_9_27_1 doi: 10.1177/0269216308101099 – ident: e_1_2_9_38_1 doi: 10.1016/j.jaip.2023.02.005 – ident: e_1_2_9_35_1 doi: 10.1038/ki.2013.454 – ident: e_1_2_9_7_1 doi: 10.1128/CMR.13.1.16 – ident: e_1_2_9_39_1 doi: 10.1016/j.jdermsci.2015.02.010 – ident: e_1_2_9_26_1 doi: 10.1016/j.cbi.2021.109395 – ident: e_1_2_9_43_1 doi: 10.2147/CCID.S135529 – ident: e_1_2_9_21_1 doi: 10.1016/j.devcel.2014.03.005 – ident: e_1_2_9_29_1 doi: 10.1186/1471-5945-5-7 – ident: e_1_2_9_4_1 doi: 10.3390/pathogens11121504 – ident: e_1_2_9_9_1 doi: 10.3390/toxins5061140 – ident: e_1_2_9_44_1 doi: 10.3390/jcm9020312 – ident: e_1_2_9_12_1 doi: 10.1016/j.jaci.2020.04.024 – ident: e_1_2_9_19_1 doi: 10.1016/j.jid.2017.05.004 – ident: e_1_2_9_40_1 doi: 10.1111/all.15640 – ident: e_1_2_9_41_1 doi: 10.1016/j.chom.2021.05.011 – ident: e_1_2_9_24_1 doi: 10.1016/j.alit.2021.11.006 – ident: e_1_2_9_11_1 doi: 10.1093/infdis/jiu223 – ident: e_1_2_9_30_1 doi: 10.1111/hdi.12301 – ident: e_1_2_9_2_1 doi: 10.2340/00015555-3296 – ident: e_1_2_9_15_1 doi: 10.1021/acs.langmuir.2c03092 – ident: e_1_2_9_37_1 doi: 10.1016/j.cyto.2020.155369 – ident: e_1_2_9_32_1 doi: 10.1111/j.1468-3083.2006.01570.x – ident: e_1_2_9_14_1 doi: 10.1038/cddis.2017.322 – ident: e_1_2_9_23_1 doi: 10.1007/s12272-021-01305-x – ident: e_1_2_9_33_1 doi: 10.1159/000519367 – ident: e_1_2_9_18_1 doi: 10.3390/ijms20215424 – ident: e_1_2_9_17_1 doi: 10.1007/s00281-013-0394-4 – ident: e_1_2_9_3_1 doi: 10.23876/j.krcp.2018.37.2.138 – ident: e_1_2_9_16_1 doi: 10.1242/jcs.033969 – volume: 11 year: 2019 ident: e_1_2_9_36_1 article-title: Pruritus associated with chronic kidney disease: a comprehensive literature review publication-title: Cureus – ident: e_1_2_9_5_1 doi: 10.1128/msphere.00116-22 – volume: 40 start-page: 8 year: 2022 ident: e_1_2_9_13_1 article-title: Physiology of the skin publication-title: Surgery – volume: 123 start-page: 917 year: 2013 ident: e_1_2_9_20_1 article-title: Coal tar induces AHR‐dependent skin barrier repair in atopic dermatitis publication-title: J Clin Invest – ident: e_1_2_9_45_1 doi: 10.1080/21505594.2021.1878688 – ident: e_1_2_9_31_1 doi: 10.1007/s11136-016-1340-4 |
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| Snippet | Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long‐term care facilities, yet its colonization and impact on the skin of... Staphylococcus aureus ( S. aureus ) commonly reside on human skin in residents in long‐term care facilities, yet its colonization and impact on the skin of... Staphylococcus aureus (S. aureus) commonly reside on human skin in residents in long-term care facilities, yet its colonization and impact on the skin of... |
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| SubjectTerms | aryl hydrocarbon receptor Colonization Down-regulation Filaggrin Gene expression Hemodialysis Keratinocytes Protein expression Proteins Pruritus Skin Staphylococcus aureus Toxins α‐toxin |
| Title | Skin colonization by Staphylococcus aureus in hemodialysis patients with pruritus and the effect of Staphylococcus aureus‐secreted α‐toxin on filaggrin expression |
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