Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type-1 antagonistic mechanism and alters cellular metabolism in intestinal epithelial cells

• Published in: BioFactors (Oxford) Vol. 51; no. 1; p. e2106
• Main Authors: Senthil Kumar, K J, Gokila Vani, M, Dakpa, Gyaltsen, Wang, Sheng-Yang
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2025
• Subjects: Adherens Junctions - drug effects; Adherens Junctions - metabolism; Caco-2 Cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Humans; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Limonene - metabolism; Limonene - pharmacology; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - genetics; Receptor, Cannabinoid, CB1 - metabolism; Tight Junction Proteins - genetics; Tight Junction Proteins - metabolism; Tight Junctions - drug effects; Tight Junctions - metabolism; Up-Regulation - drug effects; Zonula Occludens-1 Protein - genetics; Zonula Occludens-1 Protein - metabolism; limonene; intestinal epithelial cells; adherence junction; metabolites; tight junction; CB1R

Limonene, a dietary monocyclic monoterpene commonly found in citrus fruits and various aromatic plants, has garnered increasing interest as a gastrointestinal protectant. This study aimed to assess the effects of limonene on intestinal epithelial barrier function and investigate the involvement of c...