Dietary limonene promotes gastrointestinal barrier function via upregulating tight/adherens junction proteins through cannabinoid receptor type-1 antagonistic mechanism and alters cellular metabolism in intestinal epithelial cells - Senthil Kumar, K J; Gokila Vani, M; Dakpa, Gyaltsen; Wang, Sheng-Yang (BioFactors (Oxford), 2025)
Keywords: Adherens Junctions - drug effects; Adherens Junctions - metabolism; Caco-2 Cells; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Humans; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Limonene - metabolism; Limonene - pharmacology; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; Receptor, Cannabinoid, CB1 - genetics; Receptor, Cannabinoid, CB1 - metabolism; Tight Junction Proteins - genetics; Tight Junction Proteins - metabolism; Tight Junctions - drug effects; Tight Junctions - metabolism; Up-Regulation - drug effects; Zonula Occludens-1 Protein - genetics; Zonula Occludens-1 Protein - metabolism; limonene; intestinal epithelial cells; adherence junction; metabolites; tight junction; CB1R