Identification of a 10/10 matched donor for patients with an uncommon haplotype is unlikely

• Published in: HLA Vol. 89; no. 2; pp. 77 - 81
• Main Authors: Olson, J. A., Gibbens, Y., Tram, K., Kempenich, J., Novakovich, J., Buck, K., Dehn, J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2017
• Subjects: Algorithms; Alleles; Bone Marrow Transplantation - methods; Continental Population Groups; Cord Blood Stem Cell Transplantation - ethnology; Cord Blood Stem Cell Transplantation - methods; Gene Expression; Gene Frequency; haplotype; Haplotypes; Hematopoietic Stem Cell Transplantation - ethnology; Hematopoietic Stem Cell Transplantation - methods; Histocompatibility Testing; HLA Antigens - classification; HLA Antigens - genetics; HLA Antigens - immunology; HLA typing; Humans; Probability; Registries; uncommon HLA; United States; unrelated donor; Unrelated Donors - statistics & numerical data; Unrelated Donors - supply & distribution; haplotype; unrelated donor; HLA typing; uncommon HLA

Background Despite over 6 million subjects contributing to the National Marrow Donor Program human leukocyte antigen (HLA) haplotype frequency reference data (HFD), haplotypes cannot be predicted from the HLA assignments of some patients searching for an unrelated donor (URD) in the Be The Match Reg...