4β‐Hydroxywithanolide E selectively induces oxidative DNA damage for selective killing of oral cancer cells

• Published in: Environmental toxicology Vol. 33; no. 3; pp. 295 - 304
• Main Authors: Tang, Jen‐Yang, Huang, Hurng‐Wern, Wang, Hui‐Ru, Chan, Ya‐Ching, Haung, Jo‐Wen, Shu, Chih‐Wen, Wu, Yang‐Chang, Chang, Hsueh‐Wei
• Format: Journal Article
• Language: English
• Published: United States 01.03.2018
• Subjects: 4β‐hydroxywithanolide E; Acetylcysteine - pharmacology; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - metabolism; DNA Breaks, Double-Stranded - drug effects; DNA Damage - drug effects; DNA double strand break; Free Radical Scavengers - pharmacology; Gingival Neoplasms; Humans; Oxidation-Reduction; oxidative DNA damage; Oxidative Stress - drug effects; Plant Extracts - pharmacology; reactive oxygen species; Reactive Oxygen Species - metabolism; selective killing; Signal Transduction; selective killing; 4β-hydroxywithanolide E; DNA double strand break; oxidative DNA damage; reactive oxygen species

Reactive oxygen species (ROS) induction had been previously reported in 4β‐hydroxywithanolide (4βHWE)‐induced selective killing of oral cancer cells, but the mechanism involving ROS and the DNA damage effect remain unclear. This study explores the role of ROS and oxidative DNA damage of 4βHWE in the...