Phase‐shift Perfluoropentane Nanoemulsions Enhance Pulsed High‐intensity Focused Ultrasound Ablation in an Isolated Perfused Liver System and Their Potential Value for Cancer Therapy

• Published in: Journal of ultrasound in medicine Vol. 41; no. 1; pp. 107 - 121
• Main Authors: Zhao, Lu‐Yan, Chao, Xu, Yang, Bing‐She, Wang, Guo‐Guan, Zou, Jian‐Zhong, Wu, Feng
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2022
• Subjects: Animals; cancer treatment; cavitation; Fluorocarbons; High-Intensity Focused Ultrasound Ablation; high‐intensity focused ultrasound; Liver - diagnostic imaging; Liver - surgery; Neoplasms; perfusion flow rate; poly(lactic‐co‐glycolic acid) nanoemulsions; porcine liver perfusion; Rabbits; thermal ablation; cancer treatment; thermal ablation; poly(lactic-co-glycolic acid) nanoemulsions; porcine liver perfusion; high-intensity focused ultrasound; cavitation; perfusion flow rate

Purpose To investigate whether phase‐shift perfluoropetane (PFP) nanoemulsions can enhance pulsed high‐intensity focused ultrasound (HIFU) ablation. Methods PFP was encapsulated by poly(lactic‐co‐glycolic acid) (PLGA) to form a nanometer‐sized droplet (PLGA‐PFP), which was added to an isolated perfu...