The effect of vitamin C on nitroglycerin‐mediated vasodilation in individuals with and without the aldehyde dehydrogenase 2 polymorphism

• Published in: British journal of clinical pharmacology Vol. 89; no. 9; pp. 2767 - 2774
• Main Authors: He, Jerry D., Parker, John D.
• Format: Journal Article
• Language: English
• Published: England 01.09.2023
• Subjects: aldehyde dehydrogenase 2; cardiovascular pharmacology; nitroglycerin bioactivation; vitamin C; aldehyde dehydrogenase 2; nitroglycerin bioactivation; cardiovascular pharmacology; vitamin C

Aims To mediate its pharmacodynamic effects, glyceryl trinitrate (GTN) requires bioactivation, by which it releases nitric oxide or a nitric oxide moiety. The exact mechanism of GTN bioactivation remains uncertain. Mitochondrial aldehyde dehydrogenase (ALDH‐2) has been proposed as the primary enzyme...