Staging canine patients with appendicular osteosarcoma utilizing fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography compared to whole body computed tomography
Few studies have investigated the diagnostic performance of fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT) for staging veterinary patients with appendicular osteosarcoma. The purpose of this study was to evaluate the efficacy of 18F‐FDG‐PET/CT comp...
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Published in | Veterinary & comparative oncology Vol. 20; no. 3; pp. 541 - 550 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Blackwell Publishing Ltd
01.09.2022
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Abstract | Few studies have investigated the diagnostic performance of fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT) for staging veterinary patients with appendicular osteosarcoma. The purpose of this study was to evaluate the efficacy of 18F‐FDG‐PET/CT compared to whole‐body CT (WBCT) for staging canine patients with appendicular osteosarcoma. The 18F‐FDG‐PET/CT imaging studies of 66 dogs with appendicular osteosarcoma were anonymized and separated into two detached studies (one with whole body pre‐ and post‐contrast CT images and the other with the whole body pre‐ and post‐contrast CT images with the associated 18F‐FDG‐PET overlay). Image assessment was performed retrospectively by five board‐certified veterinary radiologists. The radiologists were instructed to assign a predefined categorical score (1–4) to each pre‐designated anatomic region based on a devised lesional scoring system. A score of 1 was normal, 2 abnormal but not neoplastic, 3 abnormal and concerning for neoplasia, and 4 abnormal, most likely neoplastic. Overall, the likelihood of detection of ‘3 or 4’ was found to be significantly higher with 18F‐FDG PET/CT when compared to WBCT after adjusting for the effect of evaluator and the subject. Most significantly, 13 osseous lesions concerning for metastasis (scored 3–4) were identified in 10/66 dogs by at least one reviewer on 18F‐FDG PET/CT, which were not identified by any reviewer on WBCT. Additionally, four comorbid neoplastic lesions were identified with 18F‐FDG PET/CT and not with WBCT. The results of this study suggest that 18F‐FDG PET/CT is more efficacious in detecting metastatic and comorbid neoplastic lesions compared to WBCT in dogs with appendicular osteosarcoma. |
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AbstractList | Few studies have investigated the diagnostic performance of fluorine-18-fluorodeoxyglucose (
F-FDG) positron emission tomography/computed tomography (PET/CT) for staging veterinary patients with appendicular osteosarcoma. The purpose of this study was to evaluate the efficacy of
F-FDG-PET/CT compared to whole-body CT (WBCT) for staging canine patients with appendicular osteosarcoma. The
F-FDG-PET/CT imaging studies of 66 dogs with appendicular osteosarcoma were anonymized and separated into two detached studies (one with whole body pre- and post-contrast CT images and the other with the whole body pre- and post-contrast CT images with the associated
F-FDG-PET overlay). Image assessment was performed retrospectively by five board-certified veterinary radiologists. The radiologists were instructed to assign a predefined categorical score (1-4) to each pre-designated anatomic region based on a devised lesional scoring system. A score of 1 was normal, 2 abnormal but not neoplastic, 3 abnormal and concerning for neoplasia, and 4 abnormal, most likely neoplastic. Overall, the likelihood of detection of '3 or 4' was found to be significantly higher with
F-FDG PET/CT when compared to WBCT after adjusting for the effect of evaluator and the subject. Most significantly, 13 osseous lesions concerning for metastasis (scored 3-4) were identified in 10/66 dogs by at least one reviewer on
F-FDG PET/CT, which were not identified by any reviewer on WBCT. Additionally, four comorbid neoplastic lesions were identified with
F-FDG PET/CT and not with WBCT. The results of this study suggest that
F-FDG PET/CT is more efficacious in detecting metastatic and comorbid neoplastic lesions compared to WBCT in dogs with appendicular osteosarcoma. Abstract Few studies have investigated the diagnostic performance of fluorine‐18‐fluorodeoxyglucose ( 18 F‐FDG) positron emission tomography/computed tomography (PET/CT) for staging veterinary patients with appendicular osteosarcoma. The purpose of this study was to evaluate the efficacy of 18 F‐FDG‐PET/CT compared to whole‐body CT (WBCT) for staging canine patients with appendicular osteosarcoma. The 18 F‐FDG‐PET/CT imaging studies of 66 dogs with appendicular osteosarcoma were anonymized and separated into two detached studies (one with whole body pre‐ and post‐contrast CT images and the other with the whole body pre‐ and post‐contrast CT images with the associated 18 F‐FDG‐PET overlay). Image assessment was performed retrospectively by five board‐certified veterinary radiologists. The radiologists were instructed to assign a predefined categorical score (1–4) to each pre‐designated anatomic region based on a devised lesional scoring system. A score of 1 was normal, 2 abnormal but not neoplastic, 3 abnormal and concerning for neoplasia, and 4 abnormal, most likely neoplastic. Overall, the likelihood of detection of ‘3 or 4’ was found to be significantly higher with 18 F‐FDG PET/CT when compared to WBCT after adjusting for the effect of evaluator and the subject. Most significantly, 13 osseous lesions concerning for metastasis (scored 3–4) were identified in 10/66 dogs by at least one reviewer on 18 F‐FDG PET/CT, which were not identified by any reviewer on WBCT. Additionally, four comorbid neoplastic lesions were identified with 18 F‐FDG PET/CT and not with WBCT. The results of this study suggest that 18 F‐FDG PET/CT is more efficacious in detecting metastatic and comorbid neoplastic lesions compared to WBCT in dogs with appendicular osteosarcoma. Few studies have investigated the diagnostic performance of fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT) for staging veterinary patients with appendicular osteosarcoma. The purpose of this study was to evaluate the efficacy of 18F‐FDG‐PET/CT compared to whole‐body CT (WBCT) for staging canine patients with appendicular osteosarcoma. The 18F‐FDG‐PET/CT imaging studies of 66 dogs with appendicular osteosarcoma were anonymized and separated into two detached studies (one with whole body pre‐ and post‐contrast CT images and the other with the whole body pre‐ and post‐contrast CT images with the associated 18F‐FDG‐PET overlay). Image assessment was performed retrospectively by five board‐certified veterinary radiologists. The radiologists were instructed to assign a predefined categorical score (1–4) to each pre‐designated anatomic region based on a devised lesional scoring system. A score of 1 was normal, 2 abnormal but not neoplastic, 3 abnormal and concerning for neoplasia, and 4 abnormal, most likely neoplastic. Overall, the likelihood of detection of ‘3 or 4’ was found to be significantly higher with 18F‐FDG PET/CT when compared to WBCT after adjusting for the effect of evaluator and the subject. Most significantly, 13 osseous lesions concerning for metastasis (scored 3–4) were identified in 10/66 dogs by at least one reviewer on 18F‐FDG PET/CT, which were not identified by any reviewer on WBCT. Additionally, four comorbid neoplastic lesions were identified with 18F‐FDG PET/CT and not with WBCT. The results of this study suggest that 18F‐FDG PET/CT is more efficacious in detecting metastatic and comorbid neoplastic lesions compared to WBCT in dogs with appendicular osteosarcoma. |
Author | Crooks, J. Clifton Randall, Elissa K. Brody, Ariel French, John M. Lang, Linda G. Griffin, Lynn R. |
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Cites_doi | 10.1053/j.semnuclmed.2016.12.004 10.1111/jvim.15453 10.2214/AJR.14.12932 10.1111/j.1740-8261.2010.01757.x 10.1292/jvms.13-0434 10.1371/journal.pone.0127800 10.1111/j.1939-1676.2006.tb02889.x 10.1016/j.cvsm.2015.12.008 10.1371/journal.pone.0172651 10.1111/j.1740-8261.2012.01924.x 10.3389/fvets.2019.00280 10.1148/radiographics.19.1.g99ja0761 10.1053/j.sult.2010.10.001 10.1111/j.1740-8261.2009.01520.x 10.1111/vsu.12579 10.1111/vco.12674 10.1111/j.1476-5829.2003.00021.x 10.2460/javma.2005.226.1364 10.1002/pbc.24242 10.1111/j.1748-5827.1977.tb05890.x 10.1111/vru.12959 10.1111/vco.12016 |
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melanoma publication-title: Vet Comp Oncologia contributor: fullname: Willcox JL – ident: e_1_2_9_17_1 doi: 10.1111/j.1476-5829.2003.00021.x – ident: e_1_2_9_23_1 doi: 10.2460/javma.2005.226.1364 – ident: e_1_2_9_21_1 doi: 10.1002/pbc.24242 – ident: e_1_2_9_2_1 doi: 10.1111/j.1748-5827.1977.tb05890.x – ident: e_1_2_9_5_1 doi: 10.1111/vru.12959 – ident: e_1_2_9_3_1 doi: 10.1111/vco.12016 – volume: 45 start-page: 695 issue: 4 year: 2004 ident: e_1_2_9_26_1 article-title: Selectivity of 18F‐FLT and 18F‐FDG for differentiating tumor from inflammation in a rodent model publication-title: J Nucl Med contributor: fullname: Waarde A |
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Snippet | Few studies have investigated the diagnostic performance of fluorine‐18‐fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT)... Few studies have investigated the diagnostic performance of fluorine-18-fluorodeoxyglucose ( F-FDG) positron emission tomography/computed tomography (PET/CT)... Abstract Few studies have investigated the diagnostic performance of fluorine‐18‐fluorodeoxyglucose ( 18 F‐FDG) positron emission tomography/computed... |
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Title | Staging canine patients with appendicular osteosarcoma utilizing fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography compared to whole body computed tomography |
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