Characterization and cost–benefit analysis of automated bioreactor‐expanded mesenchymal stem cells for clinical applications

• Published in: Transfusion (Philadelphia, Pa.) Vol. 58; no. 10; pp. 2374 - 2382
• Main Authors: Russell, Athena L., Lefavor, Rebecca C., Zubair, Abba C.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2018
• Subjects: Automation; Bioreactors - economics; Bioreactors - standards; Bone Marrow Cells - cytology; Cell Culture Techniques - methods; Cell Culture Techniques - standards; Cell Proliferation; Cost-Benefit Analysis; Humans; Manufacturing and Industrial Facilities - standards; Mesenchymal Stem Cells - cytology

BACKGROUND Expanding quantities of mesenchymal stem cells (MSCs) sufficient to treat large numbers of patients in cellular therapy and regenerative medicine clinical trials is an ongoing challenge for cell manufacturing facilities. STUDY DESIGN AND METHODS We evaluated options for scaling up large q...