Underlying mechanisms and chemical/biochemical therapeutic approaches to ameliorate protein misfolding neurodegenerative diseases

• Published in: BioFactors (Oxford) Vol. 43; no. 6; pp. 737 - 759
• Main Authors: Hekmatimoghaddam, Seyedhossein, Zare‐Khormizi, Mohamad Reza, Pourrajab, Fatemeh
• Format: Journal Article
• Language: English
• Published: Netherlands 01.11.2017
• Subjects: Amyloidogenic Proteins - antagonists & inhibitors; Amyloidogenic Proteins - chemistry; Amyloidogenic Proteins - genetics; Amyloidogenic Proteins - metabolism; Animals; cell proteostasis network; Chalcones - chemistry; Chalcones - pharmacology; chemical and/or biochemical therapeutic approches; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Gene Expression Regulation; Heat-Shock Response - drug effects; Humans; Hydrazones - chemistry; Hydrazones - pharmacology; Molecular Chaperones - chemistry; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Protein Aggregation, Pathological - genetics; Protein Aggregation, Pathological - metabolism; Protein Aggregation, Pathological - pathology; Protein Aggregation, Pathological - prevention & control; Protein Folding - drug effects; protein misfolding; Proteostasis - drug effects; Proteostasis Deficiencies - drug therapy; Proteostasis Deficiencies - genetics; Proteostasis Deficiencies - metabolism; Proteostasis Deficiencies - pathology; Pyrimidinones - chemistry; Pyrimidinones - pharmacology; Thiophenes - chemistry; Thiophenes - pharmacology; Unfolded Protein Response - drug effects; cell proteostasis network; chemical and/or biochemical therapeutic approches; protein misfolding

Protein misfolding and inclusion body formations are common events in neurodegenerative diseases characterized by deposition of misfolded proteins inside or outside of neurons, and are commonly referred to as “protein misfolding neurodegenerative diseases” (PMNDs). These phenotypically diverse but b...