Underlying mechanisms and chemical/biochemical therapeutic approaches to ameliorate protein misfolding neurodegenerative diseases - Hekmatimoghaddam, Seyedhossein; Zare‐Khormizi, Mohamad Reza; Pourrajab, Fatemeh (BioFactors (Oxford), 2017)
Keywords: Amyloidogenic Proteins - antagonists & inhibitors; Amyloidogenic Proteins - chemistry; Amyloidogenic Proteins - genetics; Amyloidogenic Proteins - metabolism; Animals; cell proteostasis network; Chalcones - chemistry; Chalcones - pharmacology; chemical and/or biochemical therapeutic approches; Endoplasmic Reticulum - drug effects; Endoplasmic Reticulum - metabolism; Gene Expression Regulation; Heat-Shock Response - drug effects; Humans; Hydrazones - chemistry; Hydrazones - pharmacology; Molecular Chaperones - chemistry; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Protein Aggregation, Pathological - genetics; Protein Aggregation, Pathological - metabolism; Protein Aggregation, Pathological - pathology; Protein Aggregation, Pathological - prevention & control; Protein Folding - drug effects; protein misfolding; Proteostasis - drug effects; Proteostasis Deficiencies - drug therapy; Proteostasis Deficiencies - genetics; Proteostasis Deficiencies - metabolism; Proteostasis Deficiencies - pathology; Pyrimidinones - chemistry; Pyrimidinones - pharmacology; Thiophenes - chemistry; Thiophenes - pharmacology; Unfolded Protein Response - drug effects; cell proteostasis network; chemical and/or biochemical therapeutic approches; protein misfolding