Physiologically‐based pharmacokinetic modelling guided dose evaluations of nirmatrelvir/ritonavir in renal impairment for the management of COVID‐19 - Ng, Tat Ming; Wang, Ziteng; Chan, Eric Chun Yong (British journal of clinical pharmacology, 2025)
Keywords: Antiviral Agents - administration & dosage; Antiviral Agents - pharmacokinetics; COVID-19 Drug Treatment; COVID‐19; Cytochrome P-450 CYP3A - metabolism; Dose-Response Relationship, Drug; dosing adjustment recommendation; Drug Combinations; Female; Humans; Male; Microsomes, Liver - metabolism; Middle Aged; Models, Biological; nirmatrelvir/ritonavir; physiologically‐based pharmacokinetic model; Renal Insufficiency - complications; Renal Insufficiency - metabolism; Ritonavir - administration & dosage; Ritonavir - pharmacokinetics; severe renal impairment; nirmatrelvir/ritonavir; COVID‐19; severe renal impairment; dosing adjustment recommendation; physiologically‐based pharmacokinetic model