Significance of the angiotensin I/angiotensin II/angiotensin‐(1‐7) axis in the pathogenesis of systemic sclerosis

• Published in: Journal of the European Academy of Dermatology and Venereology Vol. 34; no. 3; pp. 558 - 564
• Main Authors: Miziołek, B., Bergler‐Czop, B., Kucharz, E., Kotyla, P., Kopeć‐Mędrek, M., Widuchowska, M., Sieńczyk, M., Brzezińska‐Wcisło, L.
• Format: Journal Article
• Language: English
• Published: England 01.03.2020
• Subjects: Adult; Aged; Angiotensin I - blood; Angiotensin I - physiology; Angiotensin II - blood; Angiotensin II - physiology; Female; Humans; Male; Middle Aged; Peptide Fragments - blood; Peptide Fragments - physiology; Scleroderma, Systemic - blood; Scleroderma, Systemic - etiology; Young Adult

Background Systemic sclerosis (SSc) is a multisystemic disease with an extensive microvasculopathy. Previously, disturbances in plasma levels of angiotensin II (Ang II) and its antagonistic angiotensin‐(1‐7) (Ang‐(1‐7)) were found in patients with SSc. Their significance in a pathogenesis of SSc sta...