Relative maturity and the development of immunity to gastrointestinal nematodes in sheep: an overlooked paradigm?

Summary Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity is dependent on a number of factors, including antigenic stimulus, nutrition supply, age and size of the animals, the latter of which are co...

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Published inParasite immunology Vol. 38; no. 5; pp. 263 - 272
Main Authors Greer, A. W., Hamie, J. C.
Format Journal Article
LanguageEnglish
Published England 01.05.2016
Subjects
Animals
Gastrointestinal Diseases - immunology
Gastrointestinal Diseases - parasitology
Gastrointestinal Diseases - veterinary
genetic size scaling
Haemonchiasis - immunology
Haemonchiasis - parasitology
Haemonchiasis - veterinary
Haemonchus - physiology
immunity
nematode
relative maturity
sheep
Sheep - growth & development
Sheep - immunology
Sheep Diseases - immunology
Sheep Diseases - parasitology
genetic size scaling
nematode
immunity
relative maturity
sheep
Online AccessGet full text
ISSN0141-9838
1365-3024
DOI10.1111/pim.12313

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Abstract Summary Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity is dependent on a number of factors, including antigenic stimulus, nutrition supply, age and size of the animals, the latter of which are confounded. Here, we review the factors associated with the development of immunity to GIN in sheep, particularly in the context of the role that relative maturity may have through applying the rules of genetic size scaling based on examples from published literature. Comparing animals based on their metabolic age, rather than chronological age, may provide an explanation for the timing of immune development and may reduce the variation in immune development that frequently is observed both between and within breeds. Further, this approach may help explain the phenotypic differences in animal performance between animals of varying immunological capacity to GIN through influences on mature body weight. As such, when considering factors influencing immune development to GIN, physiological age or relative maturity may be considered an overlooked paradigm. We propose it may be worthwhile to consider metabolic age when comparing the immune competence of animals to ensure the subjects are at an analogous stage of physiological development.
AbstractList Summary Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity is dependent on a number of factors, including antigenic stimulus, nutrition supply, age and size of the animals, the latter of which are confounded. Here, we review the factors associated with the development of immunity to GIN in sheep, particularly in the context of the role that relative maturity may have through applying the rules of genetic size scaling based on examples from published literature. Comparing animals based on their metabolic age, rather than chronological age, may provide an explanation for the timing of immune development and may reduce the variation in immune development that frequently is observed both between and within breeds. Further, this approach may help explain the phenotypic differences in animal performance between animals of varying immunological capacity to GIN through influences on mature body weight. As such, when considering factors influencing immune development to GIN, physiological age or relative maturity may be considered an overlooked paradigm. We propose it may be worthwhile to consider metabolic age when comparing the immune competence of animals to ensure the subjects are at an analogous stage of physiological development.
Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity is dependent on a number of factors, including antigenic stimulus, nutrition supply, age and size of the animals, the latter of which are confounded. Here, we review the factors associated with the development of immunity to GIN in sheep, particularly in the context of the role that relative maturity may have through applying the rules of genetic size scaling based on examples from published literature. Comparing animals based on their metabolic age, rather than chronological age, may provide an explanation for the timing of immune development and may reduce the variation in immune development that frequently is observed both between and within breeds. Further, this approach may help explain the phenotypic differences in animal performance between animals of varying immunological capacity to GIN through influences on mature body weight. As such, when considering factors influencing immune development to GIN, physiological age or relative maturity may be considered an overlooked paradigm. We propose it may be worthwhile to consider metabolic age when comparing the immune competence of animals to ensure the subjects are at an analogous stage of physiological development.
Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes ( GIN ). Onset of immunity is dependent on a number of factors, including antigenic stimulus, nutrition supply, age and size of the animals, the latter of which are confounded. Here, we review the factors associated with the development of immunity to GIN in sheep, particularly in the context of the role that relative maturity may have through applying the rules of genetic size scaling based on examples from published literature. Comparing animals based on their metabolic age, rather than chronological age, may provide an explanation for the timing of immune development and may reduce the variation in immune development that frequently is observed both between and within breeds. Further, this approach may help explain the phenotypic differences in animal performance between animals of varying immunological capacity to GIN through influences on mature body weight. As such, when considering factors influencing immune development to GIN , physiological age or relative maturity may be considered an overlooked paradigm. We propose it may be worthwhile to consider metabolic age when comparing the immune competence of animals to ensure the subjects are at an analogous stage of physiological development.
Author Greer, A. W.
Hamie, J. C.
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Issue 5
Keywords genetic size scaling
nematode
immunity
relative maturity
sheep
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Snippet Summary Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity...
Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes ( GIN ). Onset of immunity is...
Sheep display considerable variation in both the timing and magnitude of development of immunity to gastrointestinal nematodes (GIN). Onset of immunity is...
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SubjectTerms Animals
Gastrointestinal Diseases - immunology
Gastrointestinal Diseases - parasitology
Gastrointestinal Diseases - veterinary
genetic size scaling
Haemonchiasis - immunology
Haemonchiasis - parasitology
Haemonchiasis - veterinary
Haemonchus - physiology
immunity
nematode
relative maturity
sheep
Sheep - growth & development
Sheep - immunology
Sheep Diseases - immunology
Sheep Diseases - parasitology
Title Relative maturity and the development of immunity to gastrointestinal nematodes in sheep: an overlooked paradigm?
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fpim.12313
https://www.ncbi.nlm.nih.gov/pubmed/26989873
https://www.proquest.com/docview/1785735044
Volume 38
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