HLA‐B leader genotypes in a clinical population

• Published in: HLA Vol. 102; no. 1; pp. 44 - 51
• Main Authors: Balgansuren, Gansuvd, Sprague, Maggie, Peterson, Paula, Shenavar, Yasaman, Ng, Ada, Regen, Lois, Shelton, Nakita, Petersdorf, Effie
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.2023
• Subjects: Alleles; Epitopes; Genotype; Hematopoietic Stem Cell Transplantation - adverse effects; HLA-B Antigens - genetics; HLA‐B leader sequence; Humans; M‐leader peptide; NGS; Prospective Studies; Receptors, KIR - genetics; rs1050458‐C/T; T‐leader peptide; T-leader peptide; rs1050458-C/T; NGS; M-leader peptide; HLA-B leader sequence; genotype

The −21 dimorphism in the leader sequences of HLA‐B exon 1 is associated with risk of graft‐versus‐host disease (GVHD), relapse and overall survival after unrelated donor hematopoietic cell transplantation (HCT), haploidentical HCT and cord blood transplantation. Consideration of the leader dimorphi...