Administration mode matters for 5‐fluorouracil therapy: Physiologically based pharmacokinetic evidence for avoidance of myelotoxicity by continuous infusion but not intravenous bolus - Chao, Chih‐Jia; Gardner, Iain; Lin, Chun‐Jung; Yeh, Kun‐Huei; Lu, Wan‐Chen; Abduljalil, Khaled; Ho, Yunn‐Fang (British journal of clinical pharmacology, 2025)
Keywords: 5‐fluorouracil; Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - adverse effects; Antimetabolites, Antineoplastic - pharmacokinetics; Bone Marrow - drug effects; Bone Marrow - metabolism; Dihydrouracil Dehydrogenase (NADP) - genetics; dose optimization; Dose-Response Relationship, Drug; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Fluorouracil - pharmacokinetics; Humans; Infusions, Intravenous; Male; Middle Aged; Models, Biological; myelotoxicity; physiologically based pharmacokinetics; myelotoxicity; 5‐fluorouracil; dose optimization; physiologically based pharmacokinetics