Trends in liver transplantation for hepatitis C in a country with reduced access to direct‐acting antiviral agents
Background Hepatitis C virus (HCV)‐related cirrhosis is a leading indication for liver transplantation (LT) worldwide. Access to effective HCV treatment is inequitable globally. We aimed to analyze whether the introduction of effective HCV treatment caused an impact in LT trends in a middle‐income c...
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| Published in | Clinical transplantation Vol. 32; no. 4; pp. e13230 - n/a |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Denmark
01.04.2018
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| Subjects | |
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| Abstract | Background
Hepatitis C virus (HCV)‐related cirrhosis is a leading indication for liver transplantation (LT) worldwide. Access to effective HCV treatment is inequitable globally. We aimed to analyze whether the introduction of effective HCV treatment caused an impact in LT trends in a middle‐income country.
Methods
Cross‐sectional analysis of all adult patients who were listed/received a LT in Argentina for HCV, alcohol‐related liver disease (ALD), or autoimmune hepatitis/primary biliary cirrhosis (AIH/PBC) from 2007 to 2017. Joinpoint regression analysis was used to identify changes in the cumulative incidence rates in waiting list (WL) registration, WL mortality, and LT.
Results
Liver transplantation WL for HCV increased significantly between 2007 and 2014, with an annual percentage change (APC) +7.8%, P = .01, followed by a downward slope from 2014 to 2017 with an APC −9.8%, P = .1. There were no significant changes in WL mortality. LT trends remained stable. LT for HCV without MELD exception points for HCC decreased (APC −6.6%, P = .01), whereas LT for HCV with HCC exception points increased (APC +11.1, P = .01) during the study period.
Conclusion
Waiting list and LT for HCV without HCC decreased, whereas LT for HCV and HCC increased; this may be related to selective antiviral treatment access for patients with advanced fibrosis. |
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| AbstractList | Background
Hepatitis C virus (HCV)‐related cirrhosis is a leading indication for liver transplantation (LT) worldwide. Access to effective HCV treatment is inequitable globally. We aimed to analyze whether the introduction of effective HCV treatment caused an impact in LT trends in a middle‐income country.
Methods
Cross‐sectional analysis of all adult patients who were listed/received a LT in Argentina for HCV, alcohol‐related liver disease (ALD), or autoimmune hepatitis/primary biliary cirrhosis (AIH/PBC) from 2007 to 2017. Joinpoint regression analysis was used to identify changes in the cumulative incidence rates in waiting list (WL) registration, WL mortality, and LT.
Results
Liver transplantation WL for HCV increased significantly between 2007 and 2014, with an annual percentage change (APC) +7.8%, P = .01, followed by a downward slope from 2014 to 2017 with an APC −9.8%, P = .1. There were no significant changes in WL mortality. LT trends remained stable. LT for HCV without MELD exception points for HCC decreased (APC −6.6%, P = .01), whereas LT for HCV with HCC exception points increased (APC +11.1, P = .01) during the study period.
Conclusion
Waiting list and LT for HCV without HCC decreased, whereas LT for HCV and HCC increased; this may be related to selective antiviral treatment access for patients with advanced fibrosis. Abstract Background Hepatitis C virus ( HCV )‐related cirrhosis is a leading indication for liver transplantation ( LT ) worldwide. Access to effective HCV treatment is inequitable globally. We aimed to analyze whether the introduction of effective HCV treatment caused an impact in LT trends in a middle‐income country. Methods Cross‐sectional analysis of all adult patients who were listed/received a LT in Argentina for HCV , alcohol‐related liver disease ( ALD ), or autoimmune hepatitis/primary biliary cirrhosis ( AIH / PBC ) from 2007 to 2017. Joinpoint regression analysis was used to identify changes in the cumulative incidence rates in waiting list ( WL ) registration, WL mortality, and LT . Results Liver transplantation WL for HCV increased significantly between 2007 and 2014, with an annual percentage change ( APC ) +7.8%, P = .01, followed by a downward slope from 2014 to 2017 with an APC −9.8%, P = .1. There were no significant changes in WL mortality. LT trends remained stable. LT for HCV without MELD exception points for HCC decreased ( APC −6.6%, P = .01), whereas LT for HCV with HCC exception points increased ( APC +11.1, P = .01) during the study period. Conclusion Waiting list and LT for HCV without HCC decreased, whereas LT for HCV and HCC increased; this may be related to selective antiviral treatment access for patients with advanced fibrosis. BACKGROUNDHepatitis C virus (HCV)-related cirrhosis is a leading indication for liver transplantation (LT) worldwide. Access to effective HCV treatment is inequitable globally. We aimed to analyze whether the introduction of effective HCV treatment caused an impact in LT trends in a middle-income country. METHODSCross-sectional analysis of all adult patients who were listed/received a LT in Argentina for HCV, alcohol-related liver disease (ALD), or autoimmune hepatitis/primary biliary cirrhosis (AIH/PBC) from 2007 to 2017. Joinpoint regression analysis was used to identify changes in the cumulative incidence rates in waiting list (WL) registration, WL mortality, and LT. RESULTSLiver transplantation WL for HCV increased significantly between 2007 and 2014, with an annual percentage change (APC) +7.8%, P = .01, followed by a downward slope from 2014 to 2017 with an APC -9.8%, P = .1. There were no significant changes in WL mortality. LT trends remained stable. LT for HCV without MELD exception points for HCC decreased (APC -6.6%, P = .01), whereas LT for HCV with HCC exception points increased (APC +11.1, P = .01) during the study period. CONCLUSIONWaiting list and LT for HCV without HCC decreased, whereas LT for HCV and HCC increased; this may be related to selective antiviral treatment access for patients with advanced fibrosis. |
| Author | Biggins, Scott W. Posadas‐Martínez, Maria L. Marciano, Sebastián Dirchwolf, Melisa Giunta, Diego H. Ruf, Andrés E. |
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| CitedBy_id | crossref_primary_10_1016_j_aohep_2018_11_003 crossref_primary_10_1016_j_aohep_2021_100344 crossref_primary_10_2807_1560_7917_ES_2019_24_41_1900176 |
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Hepatitis C virus (HCV)‐related cirrhosis is a leading indication for liver transplantation (LT) worldwide. Access to effective HCV treatment is... Abstract Background Hepatitis C virus ( HCV )‐related cirrhosis is a leading indication for liver transplantation ( LT ) worldwide. Access to effective HCV... BACKGROUNDHepatitis C virus (HCV)-related cirrhosis is a leading indication for liver transplantation (LT) worldwide. Access to effective HCV treatment is... |
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| Title | Trends in liver transplantation for hepatitis C in a country with reduced access to direct‐acting antiviral agents |
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