Identification of BAP1 mutation as a common mutation correlated with tumor mutation burden and immune infiltration in kidney renal clear cell carcinoma

• Published in: All life (Online) Vol. 15; no. 1; pp. 470 - 478
• Main Authors: Xu, Jin-Zhou, Xia, Qi-Dong, Lu, Jun-Lin, Xun, Yang, Liu, Chen-Qian, Sun, Jian-Xuan, Li, Cong, Hu, Jia, Wang, Shao-Gang
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis Ltd 31.12.2022; Taylor & Francis Group
• Subjects: BRCA1 protein; brca1-related protein 1 (bap1); Genomes; Immune response; Immunotherapy; Infiltration; kidney renal clear cell carcinoma (kirc); Mast cells; Medical prognosis; Metastases; Mutation; Point mutation; prognosis; Renal cell carcinoma; Sensitivity analysis; tumor mutation burden (tmb); Tumor suppressor genes; Tumors

Kidney renal clear cell carcinoma (KIRC) is the predominant pathological subtype of kidney cancer and is categorized as immunotherapy responsive. Hence, immunotherapy has become a worthwhile therapy for KIRC. Furthermore, tumor mutation burden (TMB) has been regarded as the most prevalent biomarker...