Enhancement of carotid chemoreceptor reflex and cardiac chemosensitive reflex in the acute phase of myocardial infarction of the anesthetized rabbit

• Published in: Basic research in cardiology Vol. 98; no. 3; pp. 175 - 180
• Main Authors: Rocha, I, Rosário, L B, de Oliveira, E I, Barros, M A, Silva-Carvallho, L
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.05.2003
• Subjects: Adenosine Triphosphate - pharmacology; Anesthesia; Animals; Baroreflex - drug effects; Baroreflex - physiology; Blood Pressure - drug effects; Carotid Body - drug effects; Carotid Body - physiology; Chemoreceptor Cells - drug effects; Chemoreceptor Cells - physiology; Female; Ganglionic Stimulants - pharmacology; Lobeline - pharmacology; Male; Myocardial Infarction - physiopathology; Rabbits; Reflex - drug effects; Reflex - physiology; Stimulation, Chemical
• ISSN: 0300-8428; 1435-1803
• DOI: 10.1007/s00395-003-0407-x

In the acute phase of cardiac ischemia there is an imbalance of the autonomic outflow with a depression of the baroreceptor reflex. Carotid chemoreceptor stimulation evokes an increase on arterial blood pressure and bradycardia in the anesthetized and paralyzed animal. The activation of cardiac chemosensitive fibers elicit the Bezold-Jarisch reflex comprising a decrease of arterial blood pressure and bradycardia. In the present study, we studied the modifications of the carotid chemoreceptor reflex and the Bezold-Jarisch reflex elicited during the acute phase of myocardial infarction (MI) in the anesthetized and paralyzed rabbit. Rabbits were anesthetized with pentobarbitone, paralyzed and artificially ventilated. The carotid sinus region was exposed and a cannula was inserted retrogradely through the external carotid artery into the carotid bifurcation; the carotid body was stimulated by a lobeline injection. A catheter was advanced, via the right carotid artery, to the origin of the aorta and the Bezold-Jarisch reflex was evoked by an injection of ATP. The baroreflex was provoked by an increase in after-load or by clamping the common carotid artery. Heart ischemia was provoked by ligation of the descending coronary artery. Arterial blood pressure, carotid artery pressure, heart rate and electrocardiogram were monitored. Stimulation of cardiovascular and cardiac receptors was performed before and after coronary ligation. Results show an overall increase in the cardiovascular reflex responses elicited by stimulation of chemically activated receptors and an overall decrease of the baroreceptor responses after MI. In conclusion, these data show the existence of an enhancement of the reflex cardiovascular responses to carotid chemoreceptor and cardiac chemosensitive receptors stimulation and confirmed the depression of baroreceptor reflexes following heart ischemia that could account for the imbalance of the autonomic output observed in the acute phase of myocardial infarction.