Integrated Omics Analysis Reveals Alterations in the Intestinal Microbiota and Metabolites of Piglets After Starvation
Obesity is a serious public health problem. Short-term starvation is an effective way to lose weight but can also cause harm to the body. However, a systematic assessment of the relationship between the intestinal microbiota and metabolites after complete fasting is lacking. Pigs are the best animal...
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| Published in | Frontiers in microbiology Vol. 13; p. 881099 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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15.06.2022
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| Abstract | Obesity is a serious public health problem. Short-term starvation is an effective way to lose weight but can also cause harm to the body. However, a systematic assessment of the relationship between the intestinal microbiota and metabolites after complete fasting is lacking. Pigs are the best animal models for exploring the mechanisms of human nutrition digestion and absorption, metabolism, and disease treatment. In this study, 16S rRNA sequencing and liquid chromatography-mass spectrometry were used to analyze the changes in the intestinal microbiota and metabolite profiles in piglets under starvation stress. The results show that the microbial composition was changed significantly in the starvation groups compared with the control group (
P
< 0.05), suggesting that shifts in the microbial composition were induced by starvation stress. Furthermore, differences in the correlation of the intestinal microbiota and metabolites were observed in the different experimental groups. Starvation may disrupt the homeostasis of the intestinal microbiota and metabolite profile and affect the health of piglets. However, piglets can regulate metabolite production to compensate for the effects of short-term starvation. Our results provide a background to explore the mechanism of diet and short-term hunger for intestinal homeostasis. |
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| AbstractList | Obesity is a serious public health problem. Short-term starvation is an effective way to lose weight but can also cause harm to the body. However, a systematic assessment of the relationship between the intestinal microbiota and metabolites after complete fasting is lacking. Pigs are the best animal models for exploring the mechanisms of human nutrition digestion and absorption, metabolism, and disease treatment. In this study, 16S rRNA sequencing and liquid chromatography-mass spectrometry were used to analyze the changes in the intestinal microbiota and metabolite profiles in piglets under starvation stress. The results show that the microbial composition was changed significantly in the starvation groups compared with the control group (
P
< 0.05), suggesting that shifts in the microbial composition were induced by starvation stress. Furthermore, differences in the correlation of the intestinal microbiota and metabolites were observed in the different experimental groups. Starvation may disrupt the homeostasis of the intestinal microbiota and metabolite profile and affect the health of piglets. However, piglets can regulate metabolite production to compensate for the effects of short-term starvation. Our results provide a background to explore the mechanism of diet and short-term hunger for intestinal homeostasis. Obesity is a serious public health problem. Short-term starvation is an effective way to lose weight but can also cause harm to the body. However, a systematic assessment of the relationship between the intestinal microbiota and metabolites after complete fasting is lacking. Pigs are the best animal models for exploring the mechanisms of human nutrition digestion and absorption, metabolism, and disease treatment. In this study, 16S rRNA sequencing and liquid chromatography-mass spectrometry were used to analyze the changes in the intestinal microbiota and metabolite profiles in piglets under starvation stress. The results show that the microbial composition was changed significantly in the starvation groups compared with the control group (P < 0.05), suggesting that shifts in the microbial composition were induced by starvation stress. Furthermore, differences in the correlation of the intestinal microbiota and metabolites were observed in the different experimental groups. Starvation may disrupt the homeostasis of the intestinal microbiota and metabolite profile and affect the health of piglets. However, piglets can regulate metabolite production to compensate for the effects of short-term starvation. Our results provide a background to explore the mechanism of diet and short-term hunger for intestinal homeostasis. Obesity is a serious public health problem. Short-term starvation is an effective way to lose weight but can also cause harm to the body. However, a systematic assessment of the relationship between the intestinal microbiota and metabolites after complete fasting is lacking. Pigs are the best animal models for exploring the mechanisms of human nutrition digestion and absorption, metabolism, and disease treatment. In this study, 16S rRNA sequencing and liquid chromatography-mass spectrometry were used to analyze the changes in the intestinal microbiota and metabolite profiles in piglets under starvation stress. The results show that the microbial composition was changed significantly in the starvation groups compared with the control group (P < 0.05), suggesting that shifts in the microbial composition were induced by starvation stress. Furthermore, differences in the correlation of the intestinal microbiota and metabolites were observed in the different experimental groups. Starvation may disrupt the homeostasis of the intestinal microbiota and metabolite profile and affect the health of piglets. However, piglets can regulate metabolite production to compensate for the effects of short-term starvation. Our results provide a background to explore the mechanism of diet and short-term hunger for intestinal homeostasis.Obesity is a serious public health problem. Short-term starvation is an effective way to lose weight but can also cause harm to the body. However, a systematic assessment of the relationship between the intestinal microbiota and metabolites after complete fasting is lacking. Pigs are the best animal models for exploring the mechanisms of human nutrition digestion and absorption, metabolism, and disease treatment. In this study, 16S rRNA sequencing and liquid chromatography-mass spectrometry were used to analyze the changes in the intestinal microbiota and metabolite profiles in piglets under starvation stress. The results show that the microbial composition was changed significantly in the starvation groups compared with the control group (P < 0.05), suggesting that shifts in the microbial composition were induced by starvation stress. Furthermore, differences in the correlation of the intestinal microbiota and metabolites were observed in the different experimental groups. Starvation may disrupt the homeostasis of the intestinal microbiota and metabolite profile and affect the health of piglets. However, piglets can regulate metabolite production to compensate for the effects of short-term starvation. Our results provide a background to explore the mechanism of diet and short-term hunger for intestinal homeostasis. |
| Author | Lu, Chang Ji, Bingzhen Qin, Junjun Guo, Xiaohong Li, Bugao Cao, Guoqing Gao, Pengfei Ma, Yijia Cai, Chunbo Liang, Guoming Yang, Yang Zhao, Yan |
| AuthorAffiliation | College of Animal Science, Shanxi Agricultural University , Taigu , China |
| AuthorAffiliation_xml | – name: College of Animal Science, Shanxi Agricultural University , Taigu , China |
| Author_xml | – sequence: 1 givenname: Yijia surname: Ma fullname: Ma, Yijia – sequence: 2 givenname: Chang surname: Lu fullname: Lu, Chang – sequence: 3 givenname: Bingzhen surname: Ji fullname: Ji, Bingzhen – sequence: 4 givenname: Junjun surname: Qin fullname: Qin, Junjun – sequence: 5 givenname: Chunbo surname: Cai fullname: Cai, Chunbo – sequence: 6 givenname: Yang surname: Yang fullname: Yang, Yang – sequence: 7 givenname: Yan surname: Zhao fullname: Zhao, Yan – sequence: 8 givenname: Guoming surname: Liang fullname: Liang, Guoming – sequence: 9 givenname: Xiaohong surname: Guo fullname: Guo, Xiaohong – sequence: 10 givenname: Guoqing surname: Cao fullname: Cao, Guoqing – sequence: 11 givenname: Bugao surname: Li fullname: Li, Bugao – sequence: 12 givenname: Pengfei surname: Gao fullname: Gao, Pengfei |
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| Copyright | Copyright © 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao. Copyright © 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao. 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao |
| Copyright_xml | – notice: Copyright © 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao. – notice: Copyright © 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao. 2022 Ma, Lu, Ji, Qin, Cai, Yang, Zhao, Liang, Guo, Cao, Li and Gao |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Microorganisms in Vertebrate Digestive Systems, a section of the journal Frontiers in Microbiology Edited by: Congying Chen, Jiangxi Agricultural University, China Reviewed by: Jia Yin, Hunan Normal University, China; Zhaolai Dai, China Agricultural University, China; Yongqing Hou, Wuhan Polytechnic University, China |
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| Title | Integrated Omics Analysis Reveals Alterations in the Intestinal Microbiota and Metabolites of Piglets After Starvation |
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