Cholestatic hepatitis associated with nimesulide--a case report

• Published in: Srpski arhiv za celokupno lekarstvo Vol. 137; no. 9-10; pp. 550 - 553
• Main Authors: Lukić, Snezana, Krstić, Miodrag, Damjanov, Nemanja, Boricić, Ivan, Popović, Dragan, Djuranović, Srdjan, Kovacević, Nada, Tomanović, Nada
• Format: Journal Article
• Language: English; Serbian
• Published: Serbia Serbian Medical Society 01.09.2009
• Subjects: Aged; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Chemical and Drug Induced Liver Injury - diagnosis; Chemical and Drug Induced Liver Injury - etiology; Cholestasis - chemically induced; Cholestasis - diagnosis; cholestatic hepatitis; Cyclooxygenase 2 Inhibitors - adverse effects; Female; hepatotoxicity; Humans; nimesulide; non-steroidal anti-inflammatory drugs; Sulfonamides - adverse effects

A toxic effect of drugs, including non-steroidal anti-inflammatory drugs, may be one of aetiological factors for the occurrence of acute hepatitis. Nimesulide is a selective cyclooxygenase-2 inhibitor, whose adverse effects on the liver range from acute hepatitis to more serious conditions, involvin...