PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes

• Published in: Experimental parasitology Vol. 265; p. 108811
• Main Authors: Autier, Brice, Verger, Alexis, Plaisse, Charleen, Manuel, Christelle, Chollet-Krugler, Marylène, Preza, Matias, Lundstroem-Stadelmann, Britta, Amela-Cortes, Marian, Aninat, Caroline, Samson, Michel, Brandhonneur, Nolwenn, Dion, Sarah
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2024; Elsevier
• Subjects: Alveolar echinococcosis; Animals; Anthelmintics - administration & dosage; Anthelmintics - chemistry; Anthelmintics - pharmacology; Drug delivery system; Drug Delivery Systems; Drug therapy; Echinococcosis - drug therapy; Echinococcus multilocularis - drug effects; EmPGI; Female; Humans; Life Sciences; Mefloquine - administration & dosage; Mefloquine - pharmacology; Mice; Mice, Inbred BALB C; Microbiology and Parasitology; Nanoparticles - chemistry; poly(lactic co-glycolic acid); Polyethylene Glycols - chemistry; Polyglactin 910; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; Alveolar echinococcosis; Drug therapy; EmPGI; Drug delivery system; poly(lactic co-glycolic acid)

Alveolar echinococcosis (AE) is a severe disease caused by the infection with the larval stage of Echinococcus multilocularis, the metacestode. As there is no actual curative drug therapy, recommendations to manage AE patients are based on radical surgery and prophylactic administration of albendazo...