Vitamin D, an inflammatory activity marker for spondyloarthritis?
Summary In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient....
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Published in | Archives of osteoporosis Vol. 15; no. 1; p. 126 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Springer London
01.12.2020
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Subjects | |
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Abstract | Summary
In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient.
Purpose
The aim of this study is to determine the association between 25-hydroxyvitamin D deficiency and level of disease activity in patients suffering from spondyloarthritis.
Methodology
This study is an observational, descriptive and transversal study. A retrospective review of patients with spondyloarthritis under treatment at the Rheumatology Department of
Hospital General Universitario de Ciudad Real
between September 2016 and September 2018 is under consideration. The association between 25-hydroxyvitamin D deficiency and levels of disease activity was calculated using odds ratio (OR) with a 95% confidence level.
Results
Initial study developments are reported. A group of 147 patients was analyzed. The average disease activity was 4.3 (according to BASDAI) and 11.4 (according to DAPSA). Twenty-eight percent of patients showed increased levels of acute-phase reactants, and 82% exhibited 25-hydroxyvitamin D deficiency/insufficiency. Analysis of the association between vitamin D deficiency/insufficiency and BASDAI/DAPSA activity degree revealed an OR of 7.9 (CI95%: 2.92–21.23,
p
= < 0.0001).
Conclusion
In this study, an association was found between those patients with spondyloarthritis who had a 25-hydroxyvitamin D deficiency and disease activity. Despite these results, a 1-year follow-up of these patients using two or more measurements of activity and 25-hydroxyvitamin D levels would be needed to corroborate these data. |
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AbstractList | Summary
In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient.
Purpose
The aim of this study is to determine the association between 25-hydroxyvitamin D deficiency and level of disease activity in patients suffering from spondyloarthritis.
Methodology
This study is an observational, descriptive and transversal study. A retrospective review of patients with spondyloarthritis under treatment at the Rheumatology Department of
Hospital General Universitario de Ciudad Real
between September 2016 and September 2018 is under consideration. The association between 25-hydroxyvitamin D deficiency and levels of disease activity was calculated using odds ratio (OR) with a 95% confidence level.
Results
Initial study developments are reported. A group of 147 patients was analyzed. The average disease activity was 4.3 (according to BASDAI) and 11.4 (according to DAPSA). Twenty-eight percent of patients showed increased levels of acute-phase reactants, and 82% exhibited 25-hydroxyvitamin D deficiency/insufficiency. Analysis of the association between vitamin D deficiency/insufficiency and BASDAI/DAPSA activity degree revealed an OR of 7.9 (CI95%: 2.92–21.23,
p
= < 0.0001).
Conclusion
In this study, an association was found between those patients with spondyloarthritis who had a 25-hydroxyvitamin D deficiency and disease activity. Despite these results, a 1-year follow-up of these patients using two or more measurements of activity and 25-hydroxyvitamin D levels would be needed to corroborate these data. In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient. PURPOSEThe aim of this study is to determine the association between 25-hydroxyvitamin D deficiency and level of disease activity in patients suffering from spondyloarthritis. METHODOLOGYThis study is an observational, descriptive and transversal study. A retrospective review of patients with spondyloarthritis under treatment at the Rheumatology Department of Hospital General Universitario de Ciudad Real between September 2016 and September 2018 is under consideration. The association between 25-hydroxyvitamin D deficiency and levels of disease activity was calculated using odds ratio (OR) with a 95% confidence level. RESULTSInitial study developments are reported. A group of 147 patients was analyzed. The average disease activity was 4.3 (according to BASDAI) and 11.4 (according to DAPSA). Twenty-eight percent of patients showed increased levels of acute-phase reactants, and 82% exhibited 25-hydroxyvitamin D deficiency/insufficiency. Analysis of the association between vitamin D deficiency/insufficiency and BASDAI/DAPSA activity degree revealed an OR of 7.9 (CI95%: 2.92-21.23, p = < 0.0001). CONCLUSIONIn this study, an association was found between those patients with spondyloarthritis who had a 25-hydroxyvitamin D deficiency and disease activity. Despite these results, a 1-year follow-up of these patients using two or more measurements of activity and 25-hydroxyvitamin D levels would be needed to corroborate these data. |
ArticleNumber | 126 |
Author | Mínguez Sánchez, María Dolores Cuadra Díaz, José Luis Luque Zafra, Miguel de Lara Simón, Isabel María Rebollo Giménez, Ana Isabel Ramírez Huaranga, Marco Aurelio Anino Fernández, Joaquín González Peñas, Marina Castro Corredor, David Mateos Rodríguez, Javier José Seoane Romero, Javier |
Author_xml | – sequence: 1 givenname: David surname: Castro Corredor fullname: Castro Corredor, David email: d.castrocorredor@gmail.com organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 2 givenname: Marco Aurelio surname: Ramírez Huaranga fullname: Ramírez Huaranga, Marco Aurelio organization: Chronic Pain Treatment Unit, General University Hospital of Ciudad Real – sequence: 3 givenname: María Dolores surname: Mínguez Sánchez fullname: Mínguez Sánchez, María Dolores organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 4 givenname: Joaquín surname: Anino Fernández fullname: Anino Fernández, Joaquín organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 5 givenname: Javier José surname: Mateos Rodríguez fullname: Mateos Rodríguez, Javier José organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 6 givenname: Ana Isabel surname: Rebollo Giménez fullname: Rebollo Giménez, Ana Isabel organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 7 givenname: Marina surname: González Peñas fullname: González Peñas, Marina organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 8 givenname: Javier surname: Seoane Romero fullname: Seoane Romero, Javier organization: Rheumatology Department, General University Hospital of Ciudad Real – sequence: 9 givenname: Miguel surname: Luque Zafra fullname: Luque Zafra, Miguel organization: Clinical Analysis Department, General University Hospital of Ciudad Real – sequence: 10 givenname: Isabel María surname: de Lara Simón fullname: de Lara Simón, Isabel María organization: Pathology Department, General University Hospital of Ciudad Real – sequence: 11 givenname: José Luis surname: Cuadra Díaz fullname: Cuadra Díaz, José Luis organization: Rheumatology Department, General University Hospital of Ciudad Real |
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Cites_doi | 10.1016/j.reuma.2013.04.002 10.1016/j.imlet.2019.06.005 10.1016/j.rbr.2014.03.027 10.2169/internalmedicine.52.9047 10.5114/reum.2018.80717 10.1016/j.rx.2013.05.004 10.1136/rmdopen-2015-000054 10.1007/s00198-005-1990-5 |
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Keywords | Inflammatory biomarkers Osteoporosis Bone mineral density Vitamin D Spondyloarthritis |
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References | Guta, Kopczynska, Hanska, Stomski, Nowakowski, Kwasny-Krochin, Gasowski, Korkosz (CR7) 2018; 56 Banegas, López, Rozas, Fernández (CR2) 2014; 56 Rios, Poddubnyy (CR3) 2015; 1 Collantes-Estevez (CR1) 2013; 9 Pokhai, Bandagi, Abrudescu (CR5) 2014; 54 Lange, Teichmann, Strunk, Müller-Ladner, Schmidt (CR6) 2005; 16 Erten, Kucuksahin, Sahin, Altunoglu, Akyol, Koca (CR4) 2013; 52 Kolahi, Khabbazi, Kazemia, Mahdavi (CR8) 2019; 212 GG Pokhai (805_CR5) 2014; 54 E Collantes-Estevez (805_CR1) 2013; 9 U Lange (805_CR6) 2005; 16 S Erten (805_CR4) 2013; 52 Z Guta (805_CR7) 2018; 56 S Kolahi (805_CR8) 2019; 212 V Rios (805_CR3) 2015; 1 ME Banegas (805_CR2) 2014; 56 |
References_xml | – volume: 9 start-page: 199 year: 2013 end-page: 200 ident: CR1 article-title: New paradigms in the diagnosis and classification of the spondylarthritis publication-title: Reumatol Clin doi: 10.1016/j.reuma.2013.04.002 contributor: fullname: Collantes-Estevez – volume: 212 start-page: 1 year: 2019 end-page: 5 ident: CR8 article-title: Does vitamin D deficiency contribute to higher disease activity in patients with spondyloarthritis? publication-title: Immunol Lett doi: 10.1016/j.imlet.2019.06.005 contributor: fullname: Mahdavi – volume: 54 start-page: 330 year: 2014 end-page: 334 ident: CR5 article-title: Vitamin D levels in ankylosing spondylitis: does deficiency correspond to disease activity? publication-title: Rev Bras Reumatol doi: 10.1016/j.rbr.2014.03.027 contributor: fullname: Abrudescu – volume: 52 start-page: 339 year: 2013 end-page: 344 ident: CR4 article-title: Decreased plasma vitamin D levels in patients with undifferentiated spondyloarthritis and ankylosing spondylitis publication-title: Intern Med doi: 10.2169/internalmedicine.52.9047 contributor: fullname: Koca – volume: 56 start-page: 388 issue: 6 year: 2018 end-page: 391 ident: CR7 article-title: Vitamin D Serum concentration is not related to the activity of spondyloarthritis – preliminary study publication-title: Reumatología doi: 10.5114/reum.2018.80717 contributor: fullname: Korkosz – volume: 56 start-page: 7 year: 2014 end-page: 15 ident: CR2 article-title: New ASAS criteria for the diagnosis of spondyloarthritis: diagnosing sacroiliitis by magnetic resonance imaging publication-title: Radiologia. doi: 10.1016/j.rx.2013.05.004 contributor: fullname: Fernández – volume: 1 start-page: e000054 issue: Suppl 1 year: 2015 ident: CR3 article-title: Old and new treatment targets in axial spondyloarthritis publication-title: RMD Open doi: 10.1136/rmdopen-2015-000054 contributor: fullname: Poddubnyy – volume: 16 start-page: 1999 year: 2005 end-page: 2004 ident: CR6 article-title: Association of 1.25 vitamin D3 deficiency, disease activity and low bone mass in ankylosing spondylitis publication-title: Osteoporos Int doi: 10.1007/s00198-005-1990-5 contributor: fullname: Schmidt – volume: 1 start-page: e000054 issue: Suppl 1 year: 2015 ident: 805_CR3 publication-title: RMD Open doi: 10.1136/rmdopen-2015-000054 contributor: fullname: V Rios – volume: 9 start-page: 199 year: 2013 ident: 805_CR1 publication-title: Reumatol Clin doi: 10.1016/j.reuma.2013.04.002 contributor: fullname: E Collantes-Estevez – volume: 52 start-page: 339 year: 2013 ident: 805_CR4 publication-title: Intern Med doi: 10.2169/internalmedicine.52.9047 contributor: fullname: S Erten – volume: 16 start-page: 1999 year: 2005 ident: 805_CR6 publication-title: Osteoporos Int doi: 10.1007/s00198-005-1990-5 contributor: fullname: U Lange – volume: 54 start-page: 330 year: 2014 ident: 805_CR5 publication-title: Rev Bras Reumatol doi: 10.1016/j.rbr.2014.03.027 contributor: fullname: GG Pokhai – volume: 56 start-page: 7 year: 2014 ident: 805_CR2 publication-title: Radiologia. doi: 10.1016/j.rx.2013.05.004 contributor: fullname: ME Banegas – volume: 212 start-page: 1 year: 2019 ident: 805_CR8 publication-title: Immunol Lett doi: 10.1016/j.imlet.2019.06.005 contributor: fullname: S Kolahi – volume: 56 start-page: 388 issue: 6 year: 2018 ident: 805_CR7 publication-title: Reumatología doi: 10.5114/reum.2018.80717 contributor: fullname: Z Guta |
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In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis.... In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore,... |
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Title | Vitamin D, an inflammatory activity marker for spondyloarthritis? |
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