A Subset of Highly Effective Propafenone-Type Multidrug Resistance Modulators Lacks Effects on Cardiac Action Potential and Mechanical Twitch Parameters of Rat Papillary Muscles

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 307; no. 2; pp. 589 - 596
• Main Authors: Schmid, Diethart, Staudacher, Dawid L, Loew, Hans G, Spieckermann, Paul G, Ecker, Gerhard F, Kopp, Stephan, Chiba, Peter
• Format: Journal Article
• Language: English
• Published: United States American Society for Pharmacology and Experimental Therapeutics 01.11.2003
• Subjects: Action Potentials - drug effects; Action Potentials - physiology; Animals; Anti-Arrhythmia Agents - chemistry; Anti-Arrhythmia Agents - pharmacology; Biological Transport - drug effects; Drug Resistance, Multiple; Heart - drug effects; Heart - physiology; Kinetics; Male; Papillary Muscles - drug effects; Papillary Muscles - physiology; Propafenone - chemistry; Propafenone - pharmacology; Rats

In this study, we tested a series of 12 previously identified, highly effective propafenone-type multidrug resistance (MDR) modulators for their possible undesirable effects on cardiac tissue. We used rat papillary muscle preparations and quantitatively determined the potency of these substances to...