The role of competing mechanisms on Lck regulation

• Published in: Immunologic research Vol. 68; no. 5; pp. 289 - 295
• Main Authors: Bozso, Sabin J., Kang, Jimmy J. H., Nagendran, Jeevan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2020
• Subjects: Allergology; Biomedical and Life Sciences; Biomedicine; Immunology; Internal Medicine; Medicine/Public Health; Review; Immune signaling; TCR; Regulation; Lck

Lck is a Src-related protein tyrosine kinase that associates with CD4 and CD8 molecules and is essential to T cell development and T cell activation. Regulatory mechanisms of Lck are diverse and controversy exists regarding the importance of each mechanism. The balance of phosphorylation at the inhi...