Frequency of the Loss of Heterozygosity of the NF2 Gene in Sporadic Spinal Schwannomas

• Published in: Anticancer research Vol. 38; no. 4; pp. 2149 - 2154
• Main Authors: DE Carvalho, Raimundo Miranda, DE Castro Sant' Anna, Carla, Pinto, Giovanny Rebouças, Paschoal, Eric Homero Albuquerque, Tuji, Fabricio Mesquita, DO Nascimento Borges, Barbara, Soares, Paulo Cardoso, Júnior, Alberto Gomes Ferreira, Rey, Juan Antonio, Chaves, Luiz Cláudio Lopes, Burbano, Rommel Rodriguez
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.04.2018
• Subjects: Alleles; Etiology; Genetic disorders; Heterozygosity; Loss of heterozygosity; Mutation; Neurofibromatosis; Neurofibromatosis 2; Neurofibromin 2; Neurological disorders; Patients; Schwann cells; Tumors; spinal schwannoma; FISH; Mutation; LOH

Individuals with type 2 Neurofibromatosis are predisposed for the appearance of schwannomas. In the present study we analyzed the loss of heterozygosity and mutations in the NF2 gene in patients with sporadic Schwannoma without Neurofibromatosis type 2. We analyzed 39 patients with sporadic spinal s...