Galectins in cancer: carcinogenesis, diagnosis and therapy
A major breakthrough in the field of medical oncology has been the discovery of galectins and their role in cancer development, progression and metastasis. In this review article we have condensed the results of a number of studies published over the past decade in an effort to shed some light on th...
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| Published in | Annals of translational medicine Vol. 2; no. 9; p. 88 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
China
AME Publishing Company
01.09.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A major breakthrough in the field of medical oncology has been the discovery of galectins and their role in cancer development, progression and metastasis. In this review article we have condensed the results of a number of studies published over the past decade in an effort to shed some light on the unique role played by the galectin family of proteins in neoplasia, and how this knowledge may alter the approach to cancer diagnosis as well as therapy in the future. In this review we have also emphasized the potential use of galectin inhibitors or modulators in the treatment of cancer and how this novel treatment modality may affect patient outcomes in the future. Based on current pre-clinical models we believe the use of galectin inhibitors/modulators will play a significant role in cancer treatment in the future. Early clinical studies are underway to evaluate the utility of these promising agents in cancer patients. |
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| AbstractList | A major breakthrough in the field of medical oncology has been the discovery of galectins and their role in cancer development, progression and metastasis. In this review article we have condensed the results of a number of studies published over the past decade in an effort to shed some light on the unique role played by the galectin family of proteins in neoplasia, and how this knowledge may alter the approach to cancer diagnosis as well as therapy in the future. In this review we have also emphasized the potential use of galectin inhibitors or modulators in the treatment of cancer and how this novel treatment modality may affect patient outcomes in the future. Based on current pre-clinical models we believe the use of galectin inhibitors/modulators will play a significant role in cancer treatment in the future. Early clinical studies are underway to evaluate the utility of these promising agents in cancer patients. |
| Author | Rakhshanda, Rahman Jenkins, Marjorie Grizzi, Fabio Ebrahim, Ali Hasan Nguyen, Diane Cobos, Everardo Dahlbeck, Scott Figueroa, Jose A Alalawi, Zainab Chiriva-Internati, Maurizio Mirandola, Leonardo |
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Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 3 givenname: Leonardo surname: Mirandola fullname: Mirandola, Leonardo organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 4 givenname: Rahman surname: Rakhshanda fullname: Rakhshanda, Rahman organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 5 givenname: Scott surname: Dahlbeck fullname: Dahlbeck, Scott organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 6 givenname: Diane surname: Nguyen fullname: Nguyen, Diane organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 7 givenname: Marjorie surname: Jenkins fullname: Jenkins, Marjorie organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 8 givenname: Fabio surname: Grizzi fullname: Grizzi, Fabio organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 9 givenname: Everardo surname: Cobos fullname: Cobos, Everardo organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 10 givenname: Jose A surname: Figueroa fullname: Figueroa, Jose A organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy – sequence: 11 givenname: Maurizio surname: Chiriva-Internati fullname: Chiriva-Internati, Maurizio organization: 1 Department of Surgery, 2 Internal Medicine Department, Salmaniya Medical Complex, Kingdom of Bahrain ; 3 Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA ; 4 Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, TX, USA ; 5 Division of Surgical Oncology, Texas Tech University Medical Center, Amarillo, TX, USA ; 6 Kiromic, LLC, TX, USA ; 7 Humanitas Clinical and Research Center, Milan, Italy |
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| Copyright | 2014 Annals of Translational Medicine. All rights reserved. 2014 Annals of Translational Medicine. |
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| Keywords | galectins solid tumors lectins Cancer |
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