Transcriptome changes in DM1 patients’ tissues are governed by the RNA interference pathway

• Published in: Frontiers in molecular biosciences Vol. 9; p. 955753
• Main Authors: Braun, Maya, Shoshani, Shachar, Tabach, Yuval
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 19.08.2022
• Subjects: expansion repeat disorders; gene signature; Molecular Biosciences; myotonic dystrophy type 1; RNA interference; small RNAs; trinucleotide repeats

Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by pathogenic expansions of CTG repeats. The expanded repeats are transcribed to long RNA and induce cellular toxicity. Recent studies suggest that the CUG repeats are processed by the RNA interference (RNAi) pathway to generate small...