Epigenetic Downregulation of FASN in Visceral Adipose Tissue of Insulin Resistant Subjects

• Published in: Experimental and clinical endocrinology & diabetes Vol. 129; no. 9; p. 674
• Main Authors: Sievert, Helen, Krause, Christin, Geißler, Cathleen, Grohs, Martina, El-Gammal, Alexander T, Wolter, Stefan, Mann, Oliver, Lehnert, Hendrik, Kirchner, Henriette
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2021
• Subjects: Adult; DNA Methylation - physiology; Down-Regulation; Epigenesis, Genetic - physiology; Fatty Acid Synthase, Type I - metabolism; Female; Glucose Intolerance - metabolism; Glycated Hemoglobin A - metabolism; Humans; Insulin Resistance - physiology; Intra-Abdominal Fat - metabolism; Male; Middle Aged; Obesity, Morbid - blood; Obesity, Morbid - metabolism

The risk to develop type 2 diabetes increases with the amount of visceral adiposity presumably due to increased lipolysis and subsequent lipid accumulation in visceral organs. However, data describing the molecular regulation of these pathways in humans are rare. We tested if genes of the lipogenic...