Neurocognitive processing of esophageal central sensitization in the insula and cingulate gyrus

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 294; no. 3; pp. G787 - G794
• Main Authors: Lawal, Adeyemi, Kern, Mark, Sanjeevi, Arthi, Antonik, Stephen, Mepani, Rachel, Rittmann, Tanya, Hussaini, Syed, Hofmann, Candy, Tatro, Linda, Jesmanowicz, Andrzej, Verber, Matt, Shaker, Reza
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2008
• Subjects: Acids; Adolescent; Adult; Catheterization; Cerebral Cortex - physiology; Cognition - physiology; Dilatation; Esophagus; Esophagus - innervation; Esophagus - physiology; Female; Gastroesophageal Reflux - physiopathology; Gyrus Cinguli - physiology; Humans; Hydrochloric Acid - pharmacology; Hydrogen-Ion Concentration; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Nerve Net - physiology; Neurons; NMR; Nuclear magnetic resonance; Pain - physiopathology; Physical Stimulation; Stimulation, Chemical; Studies

The cingulate and insular cortices are parts of the limbic system that process and modulate gastrointestinal sensory signals. We hypothesized that sensitization of these two limbic area may operate in esophageal sensitization. Thus the objective of the study was to elucidate the neurocognitive proce...