Effect of prior chemotherapy regimens on the efficacy of endocrine therapy within a German cohort of the TEAM trial

• Published in: Journal of cancer research and clinical oncology Vol. 140; no. 1; pp. 117 - 126
• Main Authors: Bossart, Michaela, Hadji, Peyman, Klar, Maximilian, Kieback, Dirk G., Hasenburg, Annette
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 2014; Springer Nature B.V
• Subjects: Androstadienes - administration & dosage; Androstadienes - therapeutic use; Antineoplastic Agents, Hormonal - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Aromatase Inhibitors - therapeutic use; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer Research; Chemotherapy; Chemotherapy, Adjuvant; Clinical outcomes; Cohort Studies; Disease-Free Survival; Endocrine therapy; Female; Hematology; Humans; Internal Medicine; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Grading; Neoplasm Staging; Oncology; Original Paper; Postmenopause; Retrospective Studies; Survival Rate; Tamoxifen - administration & dosage; Germany; Endocrine therapy; Aromatase inhibitor; Early breast cancer; Exemestane

Purpose Prior chemotherapy may affect the efficacy of endocrine therapy. Methods The tamoxifen exemestane adjuvant multinational (TEAM) trial compared 5 years of adjuvant exemestane with the sequence of tamoxifen followed by exemestane in postmenopausal women with hormone-receptor-positive breast ca...