Exploring the multifaceted role of NRF2 in brain physiology and cancer: A comprehensive review

• Published in: Neuro-oncology advances Vol. 6; no. 1; p. vdad160
• Main Authors: Moubarak, Maya M, Pagano Zottola, Antonio C, Larrieu, Claire M, Cuvellier, Sylvain, Daubon, Thomas, Martin, Océane C B
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.01.2024
• Subjects: NRF2; therapeutic resistance; glioblastoma stem cells; oxidative stress; Brain physiology

Abstract Chronic oxidative stress plays a critical role in the development of brain malignancies due to the high rate of brain oxygen utilization and concomitant production of reactive oxygen species. The nuclear factor-erythroid-2-related factor 2 (NRF2), a master regulator of antioxidant signaling...