Comparison of Bayesian and frequentist monitoring boundaries motivated by the Multiplatform Randomized Clinical Trial

• Published in: Clinical trials (London, England) Vol. 21; no. 6; p. 701
• Main Authors: Joo, Jungnam, Leifer, Eric S, Proschan, Michael A, Troendle, James F, Reynolds, Harmony R, Hade, Erinn A, Lawler, Patrick R, Kim, Dong-Yun, Geller, Nancy L
• Format: Journal Article
• Language: English
• Published: England 01.12.2024
• Subjects: Bayes Theorem; COVID-19; Humans; Medical Futility; Randomized Controlled Trials as Topic - methods; Research Design; SARS-CoV-2; frequentist; Bayesian; prior patients; monitoring guidelines

The coronavirus disease 2019 pandemic highlighted the need to conduct efficient randomized clinical trials with interim monitoring guidelines for efficacy and futility. Several randomized coronavirus disease 2019 trials, including the Multiplatform Randomized Clinical Trial (mpRCT), used Bayesian gu...