Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects

• Published in: The American journal of clinical nutrition Vol. 87; no. 6; pp. 1723 - 1729
• Main Authors: Frank, Jan, Lee, Sangeun, Leonard, Scott W, Atkinson, Jeffrey K, Kamal-Eldin, Afaf, Traber, Maret G
• Format: Journal Article
• Language: English
• Published: United States 01.06.2008
• Subjects: alpha-Tocopherol - metabolism; Body Mass Index; Chromatography, Liquid; Cross-Over Studies; dietary fat; dose response; Female; gamma-tocopherol; gamma-Tocopherol - administration & dosage; gamma-Tocopherol - metabolism; gender differences; Humans; lignans; lipid metabolism; Lipids - blood; Male; Mass Spectrometry; men; Reference Values; Sesame Oil; Sex Characteristics; women

Gamma-tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances gamma-tocopherol turnover. Our aim was to determine the extent to which dietary sesame lignans alter human alpha- and gamma-tocopherol metabolism and eliminatio...