Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 296; no. 3; pp. G510 - G516
• Main Authors: Camilleri, Michael, Carlson, Paula, Zinsmeister, Alan R, McKinzie, Sanna, Busciglio, Irene, Burton, Duane, Zaki, Essam A, Boles, Richard G
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2009
• Subjects: Adult; Cells; Constipation - epidemiology; Constipation - genetics; Constipation - physiopathology; Digestive system; DNA, Mitochondrial - genetics; Dyspepsia - epidemiology; Dyspepsia - genetics; Dyspepsia - physiopathology; Enteric Nervous System - physiology; Gastrointestinal diseases; Gastrointestinal Diseases - epidemiology; Gastrointestinal Diseases - genetics; Gastrointestinal Diseases - physiopathology; Gastrointestinal Motility - genetics; Genetic Predisposition to Disease - epidemiology; Haplotypes; Humans; Irritable bowel syndrome; Irritable Bowel Syndrome - epidemiology; Irritable Bowel Syndrome - genetics; Irritable Bowel Syndrome - physiopathology; Middle Aged; Mitochondrial DNA; Motor Neurons - physiology; Phenotype; Polymorphism; Polymorphism, Single Nucleotide; Risk Factors; Sensory Receptor Cells - physiology

Nerve, muscle, and inflammatory cells involved in gastrointestinal (GI) function have high-energy requirements and are affected in mitochondrial disorders. Familial aggregation of irritable bowel syndrome (IBS) frequently involves mothers and their children. Since mitochondrial DNA (mtDNA) is matern...