High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

• Published in: Science China. Life sciences Vol. 67; no. 8; pp. 1635 - 1647
• Main Authors: Liu, Feng-Qi, Qu, Qing-Yuan, Lei, Ying, Chen, Qi, Chen, Yu-Xiu, Li, Meng-Lin, Sun, Xue-Yan, Wu, Ye-Jun, Huang, Qiu-Sha, Fu, Hai-Xia, Kong, Yuan, Li, Yue-Ying, Wang, Qian-Fei, Huang, Xiao-Jun, Zhang, Xiao-Hui
• Format: Journal Article
• Language: English
• Published: Beijing Science China Press 01.08.2024; Springer Nature B.V
• Subjects: Adult; Aged; Antigen-presenting cells; Biomedical and Life Sciences; Bone marrow; Bone Marrow - immunology; BTLA protein; CD86 antigen; Cell activation; Cell surface; CTLA-4 protein; Effector cells; Female; Helper cells; Humans; Idiopathic thrombocytopenic purpura; Immunological memory; Immunological tolerance; Immunomodulation; Immunotherapy; Life Sciences; Lymphocytes B; Lymphocytes T; Male; Memory cells; Middle Aged; Monocytes; Platelet Count; Platelets; Proteomics; Proteomics - methods; Purpura, Thrombocytopenic, Idiopathic - blood; Purpura, Thrombocytopenic, Idiopathic - immunology; Research Paper; Thrombocytopenia; Young Adult; autoimmune diseases; co-stimulatory; immune thrombocytopenia; immune checkpoint; CTLA4; Cytometry by Time of Flight; co-inhibitory; bone marrow

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight (CyTOF). Thirty-six patients with ITP and n...