Early immune outcome of retroperitoneal laparoscopic radical nephrectomy for localized renal cell carcinoma: a prospective, randomized study
We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC). A total of 62 patients with T(1)N(0)M(0) staged RCC were randomized to either retro-laparoscopic (n = 3...
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Published in | Canadian Urological Association journal Vol. 6; no. 6; p. E242 |
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Format | Journal Article |
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Canadian Urological Association
01.12.2012
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Abstract | We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC).
A total of 62 patients with T(1)N(0)M(0) staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-alpha (TNF-α) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels of CD3(+), CD4(+) and CD8(+) as well as the CD4(+):CD8(+) ratio were acquired by flow cytometry at the same time points.
Levels of IL-1β, IL-6 and TNF-α increased significantly compared to preoperative values in both groups (p < 0.05) on postoperative day 1, and all the parameters in the open group were significantly higher than those in the retro-laparoscopy group (p < 0.05). On postoperative day 1, the levels of CD3(+) and CD4(+) and the CD4(+):CD8(+) ratio decreased markedly compared to preoperative values for both groups (p < 0.05). Elevations of the CD4(+):CD8(+) ratio in the retro-laparoscopy group (p < 0.05) and the CD8(+) level in the open group (p < 0.05) were observed when compared with the other group. On postoperative day 5, the levels of CD3(+) and CD4(+) and the CD4(+):CD8(+) ratio in the retro-laparoscopy group, as well as the level of CD8(+) in the open group, returned to about preoperative levels (p < 0.05). Follow-up ranged from 4 to 14 months postoperatively in all 62 patients with a 100% cancer-specific survival rate in both groups.
Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution of T-lymphocytes. |
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AbstractList | Objectives: We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC). Methods: A total of 62 patients with T.sub.1 N.sub.0 M.sub.0 staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1[beta] (IL-1[beta]), IL-6, and tumour necrosis factor-alpha (TNF-[alpha]) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels of CD3.sup.+ , CD4.sup.+ and CD8.sup.+ as well as the CD4.sup.+ :CD8.sup.+ ratio were acquired by flow cytometry at the same time points. Results: Levels of IL-1[beta], IL-6 and TNF-[alpha] increased significantly compared to preoperative values in both groups (p [less than] 0.05) on postoperative day 1, and all the parameters in the open group were significantly higher than those in the retro-laparoscopy group (p [less than] 0.05). On postoperative day 1, the levels of CD3.sup.+ and CD4.sup.+ and the CD4.sup.+ :CD8.sup.+ ratio decreased markedly compared to preoperative values for both groups (p [less than] 0.05). Elevations of the CD4.sup.+ :CD8.sup.+ ratio in the retro-laparoscopy group (p [less than] 0.05) and the CD8.sup.+ level in the open group (p [less than] 0.05) were observed when compared with the other group. On postoperative day 5, the levels of CD3.sup.+ and CD4.sup.+ and the CD4.sup.+ :CD8.sup.+ ratio in the retro-laparoscopy group, as well as the level of CD8.sup.+ in the open group, returned to about preoperative levels (p [less than] 0.05). Follow-up ranged from 4 to 14 months postoperatively in all 62 patients with a 100% cancer-specific survival rate in both groups. Conclusions: Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution of T-lymphocytes. We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC). A total of 62 patients with T.sub.1 N.sub.0 M.sub.0 staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1[beta] (IL-1[beta]), IL-6, and tumour necrosis factor-alpha (TNF-[alpha]) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels of CD3.sup.+ , CD4.sup.+ and CD8.sup.+ as well as the CD4.sup.+ :CD8.sup.+ ratio were acquired by flow cytometry at the same time points. Levels of IL-1[beta], IL-6 and TNF-[alpha] increased significantly compared to preoperative values in both groups (p [less than] 0.05) on postoperative day 1, and all the parameters in the open group were significantly higher than those in the retro-laparoscopy group (p [less than] 0.05). On postoperative day 1, the levels of CD3.sup.+ and CD4.sup.+ and the CD4.sup.+ :CD8.sup.+ ratio decreased markedly compared to preoperative values for both groups (p [less than] 0.05). Elevations of the CD4.sup.+ :CD8.sup.+ ratio in the retro-laparoscopy group (p [less than] 0.05) and the CD8.sup.+ level in the open group (p [less than] 0.05) were observed when compared with the other group. On postoperative day 5, the levels of CD3.sup.+ and CD4.sup.+ and the CD4.sup.+ :CD8.sup.+ ratio in the retro-laparoscopy group, as well as the level of CD8.sup.+ in the open group, returned to about preoperative levels (p [less than] 0.05). Follow-up ranged from 4 to 14 months postoperatively in all 62 patients with a 100% cancer-specific survival rate in both groups. Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution of T-lymphocytes. Objectives: We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic andconventional open radical nephrectomies for localized renal cellcarcinoma (RCC).Methods: A total of 62 patients with T1N0M0 staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1β (IL-1β), IL-6, andtumour necrosis factor-alpha (TNF-α) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels of CD3+, CD4+ and CD8+ as well as the CD4+:CD8+ ratio were acquired by flow cytometry at the same time points.Results: Levels of IL-1β, IL-6 and TNF-α increased significantly compared to preoperative values in both groups (p < 0.05) on postoperative day 1, and all the parameters in the open group were significantly higher than those in the retro-laparoscopy group (p < 0.05). On postoperative day 1, the levels of CD3+ and CD4+ and the CD4+:CD8+ ratio decreased markedly compared to preoperative values for both groups (p < 0.05). Elevations of the CD4+:CD8+ ratio in the retro-laparoscopy group (p < 0.05) and the CD8+ level in the open group (p < 0.05) were observed when compared with the other group. On postoperative day 5, the levels of CD3+ and CD4+ and the CD4+:CD8+ ratio in the retro-laparoscopy group, as well as the level of CD8+ in the open group, returned to about preoperative levels (p < 0.05). Follow-up ranged from 4 to14 months postoperatively in all 62 patients with a 100% cancer specific survival rate in both groups.Conclusions: Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution ofT-lymphocytes. We evaluated differences in cytokine responses and T-lymphocyte subsets following retroperitoneal laparoscopic and conventional open radical nephrectomies for localized renal cell carcinoma (RCC). A total of 62 patients with T(1)N(0)M(0) staged RCC were randomized to either retro-laparoscopic (n = 31) or open (n = 31) radical nephrectomy. Plasma levels of interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-alpha (TNF-α) were measured separately by enzyme linked immunosorbent assay (ELISA) preoperatively and on postoperative days 1 and 5. Levels of CD3(+), CD4(+) and CD8(+) as well as the CD4(+):CD8(+) ratio were acquired by flow cytometry at the same time points. Levels of IL-1β, IL-6 and TNF-α increased significantly compared to preoperative values in both groups (p < 0.05) on postoperative day 1, and all the parameters in the open group were significantly higher than those in the retro-laparoscopy group (p < 0.05). On postoperative day 1, the levels of CD3(+) and CD4(+) and the CD4(+):CD8(+) ratio decreased markedly compared to preoperative values for both groups (p < 0.05). Elevations of the CD4(+):CD8(+) ratio in the retro-laparoscopy group (p < 0.05) and the CD8(+) level in the open group (p < 0.05) were observed when compared with the other group. On postoperative day 5, the levels of CD3(+) and CD4(+) and the CD4(+):CD8(+) ratio in the retro-laparoscopy group, as well as the level of CD8(+) in the open group, returned to about preoperative levels (p < 0.05). Follow-up ranged from 4 to 14 months postoperatively in all 62 patients with a 100% cancer-specific survival rate in both groups. Retroperitoneal laparoscopic radical nephrectomy is associated with the milder cytokine responses caused by trauma and inflammation and the better preserved distribution of T-lymphocytes. |
Audience | Academic |
Author | Qiang, Wei Xiaobo, Cui Lu, Yang Ping, Han Tianyong, Fan Siyuan, Bu |
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References | 17287172 - Hepatobiliary Pancreat Dis Int. 2007 Feb;6(1):81-6 15791361 - Surg Endosc. 2004 Oct;18(10):1411-9 8916880 - Ann Surg. 1996 Nov;224(5):647-64 9240130 - Br J Surg. 1997 Jul;84(7):920-35 9678378 - Dis Colon Rectum. 1998 Jul;41(7):901-9 10566539 - Dis Colon Rectum. 1999 Nov;42(11):1480-6 18265990 - World J Urol. 2008 Apr;26(2):127-33 19916010 - World J Urol. 2010 Jun;28(3):289-93 20922542 - Int J Colorectal Dis. 2011 Jan;26(1):53-9 18811573 - J Endourol. 2008 Sep;22(9):2161-4 16364716 - Surgery. 2006 Jan;139(1):39-45 10805546 - Dig Surg. 1999;16(6):471-7 10064753 - Surg Endosc. 1999 Mar;13(3):233-5 18342166 - Urology. 2008 Mar;71(3):372-8 15532785 - Hepatogastroenterology. 2004 Nov-Dec;51(60):1595-9 18392834 - World J Urol. 2008 Apr;26(2):115-25 15996197 - Clin Exp Immunol. 2005 Aug;141(2):326-32 16283854 - J Endourol. 2005 Nov;19(9):1140-5 17786453 - World J Urol. 2007 Dec;25(6):619-26 15136930 - Surg Endosc. 2004 Jul;18(7):1022-8 1830346 - J Urol. 1991 Aug;146(2):278-82 15191862 - Am J Surg. 2004 Jun;187(6):705-12 10069630 - Eur J Surg. 1999 Jan;165(1):21-8 19020880 - World J Urol. 2009 Feb;27(1):81-8 10437613 - Langenbecks Arch Surg. 1999 Jun;384(3):250-8 15608426 - Adv Otorhinolaryngol. 2005;62:161-72 9527054 - Ann Surg. 1998 Mar;227(3):326-34 7726672 - Ann Surg. 1995 Apr;221(4):372-80 8661626 - World J Surg. 1996 Jun;20(5):528-33; discussion 533-4 15212338 - Best Pract Res Clin Anaesthesiol. 2004 Sep;18(3):439-54 12103285 - Lancet. 2002 Jun 29;359(9325):2224-9 15017197 - J Urol. 2004 Apr;171(4):1456-60 18639228 - Am J Surg. 2009 Feb;197(2):238-45 |
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Title | Early immune outcome of retroperitoneal laparoscopic radical nephrectomy for localized renal cell carcinoma: a prospective, randomized study |
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