Ocular Pharmacokinetics of Mapracorat, a Novel, Selective Glucocorticoid Receptor Agonist, in Rabbits and Monkeys

• Published in: Drug metabolism and disposition Vol. 39; no. 7; pp. 1181 - 1187
• Main Authors: PROKSCH, Joel W, LOWE, Ezra R, WARD, Keith W
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.07.2011
• Subjects: Animals; Benzofurans - pharmacokinetics; Biological and medical sciences; Chromatography, Liquid; Dexamethasone - pharmacokinetics; Dose-Response Relationship, Drug; Eye - metabolism; Female; Macaca fascicularis; Male; Medical sciences; Pentanols - pharmacokinetics; Pharmacology. Drug treatments; Prednisolone - pharmacokinetics; Quinolines - pharmacokinetics; Rabbits; Receptors, Glucocorticoid - agonists; Tandem Mass Spectrometry; Agonist; Antiinflammatory agent; Monkey; Rabbit; Lagomorpha; Eye; Visual system; Vertebrata; Mapracorat; Mammalia; Animal; Glucocorticoid receptor; Primates; Pharmacokinetics; Hormonal receptor

Mapracorat is a selective glucocorticoid receptor agonist in development for the treatment of a variety of ocular diseases. The purpose of this investigation was to evaluate the ocular pharmacokinetics of mapracorat after topical dosing over a range of dose levels in rabbits and monkeys. Mapracorat...