Phosphine/Lewis acid mediated reformatsky-type reaction of alpha-bromoketone or -thioester derivatives

The combination Of (o-tolyl)(3)P/TiCl4 effectively promoted the Reformatsky-type reaction of alpha-bromoketone or -thioester derivatives with various aldehydes, and the corresponding beta-hydroxy carbonyl compounds were obtained in good yield with high diastereoselectivity.

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Bibliographic Details
Published inChemistry letters no. 2; pp. 126 - 127
Main Authors Hashimoto, Y, Kikuchi, S
Format Journal Article
LanguageEnglish
Published TOKYO Chemical Soc Japan 05.02.2002
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
AGENT
REDUCTION
ALDEHYDES
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Summary:The combination Of (o-tolyl)(3)P/TiCl4 effectively promoted the Reformatsky-type reaction of alpha-bromoketone or -thioester derivatives with various aldehydes, and the corresponding beta-hydroxy carbonyl compounds were obtained in good yield with high diastereoselectivity.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2002.126