OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation

• Published in: Development (Cambridge) Vol. 128; no. 23; pp. 4801 - 4813
• Main Authors: Acampora, D, Boyl, P P, Signore, M, Martinez-Barbera, J P, Ilengo, C, Puelles, E, Annino, A, Reichert, H, Corte, G, Simeone, A
• Format: Journal Article
• Language: English
• Published: England 01.12.2001
• Subjects: 3' Untranslated Regions; 5' Untranslated Regions; Active Transport, Cell Nucleus; Animals; Biological Evolution; Body Patterning - genetics; Brain - embryology; Brain - metabolism; Cytoplasm - metabolism; DNA, Complementary - genetics; Drosophila - embryology; Drosophila - genetics; Drosophila melanogaster; Drosophila Proteins; Homeodomain Proteins - genetics; Mice; Mice, Knockout; Morphogenesis; Nerve Tissue Proteins - genetics; orthodenticle (otd) gene; OTD protein; Otx Transcription Factors; Otx1 gene; Otx2 gene; OTX2 protein; Phenotype; Protein Biosynthesis; RNA, Messenger - genetics; RNA, Messenger - metabolism; Species Specificity; Trans-Activators - genetics

How gene activity is translated into phenotype and how it can modify morphogenetic pathways is of central importance when studying the evolution of regulatory control mechanisms. Previous studies in mouse have suggested that, despite the homeodomain-restricted homology, Drosophila orthodenticle (otd...