Antioxidant supplementation for sickle cell disease

• Published in: Cochrane database of systematic reviews Vol. 5; p. CD013590
• Main Authors: Bolarinwa, Abiola B, Oduwole, Olabisi, Okebe, Joseph, Ogbenna, Ann A, Otokiti, Oluwakemi E, Olatinwo, Adejoke T
• Format: Journal Article
• Language: English
• Published: England 22.05.2024
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - blood; Anemia, Sickle Cell - drug therapy; Antioxidants - therapeutic use; Ascorbic Acid - therapeutic use; Bias; Child; Dietary Supplements; Humans; Oxidative Stress - drug effects; Placebos - therapeutic use; Quality of Life; Randomized Controlled Trials as Topic

Sickle cell disease (SCD) refers to a group of genetic disorders characterized by the presence of an abnormal haemoglobin molecule called haemoglobin S (HbS). When subjected to oxidative stress from low oxygen concentrations, HbS molecules form rigid polymers, giving the red cell the typical sickle...