NAD+ metabolism and therapeutic strategies in cardiovascular diseases
Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the card...
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Published in | Atherosclerosis plus Vol. 57; pp. 1 - 12 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.09.2024
Elsevier |
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Abstract | Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic.
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AbstractList | Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic. Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic. Image 1 Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic. [Display omitted] Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic.Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic. |
Author | Shi, Linsheng Shi, Chongxu Yang, Yihang Wen, Zhaozhi Liu, Dong |
Author_xml | – sequence: 1 givenname: Chongxu orcidid: 0009-0006-2012-2322 surname: Shi fullname: Shi, Chongxu email: Chongxu.shi@gmail.com organization: Nantong Laboratory of Development and Diseases, School of Life Science, Nantong University, Nantong, China – sequence: 2 givenname: Zhaozhi surname: Wen fullname: Wen, Zhaozhi organization: Nantong Laboratory of Development and Diseases, School of Life Science, Nantong University, Nantong, China – sequence: 3 givenname: Yihang surname: Yang fullname: Yang, Yihang organization: Nantong Laboratory of Development and Diseases, School of Life Science, Nantong University, Nantong, China – sequence: 4 givenname: Linsheng surname: Shi fullname: Shi, Linsheng email: shilinsheng@ntu.edu.cn organization: Department of Cardiology, The Second Affiliated Hospital of Nantong University, Nantong, China – sequence: 5 givenname: Dong surname: Liu fullname: Liu, Dong email: liudongtom@gmail.com organization: Nantong Laboratory of Development and Diseases, School of Life Science, Nantong University, Nantong, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38974325$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1038/ncomms12948 10.1186/s12970-021-00442-4 10.1113/jphysiol.2012.229690 10.1016/j.cmet.2019.05.015 10.1146/annurev.nutr.28.061807.155443 10.1038/ng1295-376 10.1161/CIRCRESAHA.115.304634 10.1016/j.metabol.2021.154923 10.1016/j.atherosclerosis.2017.08.027 10.1152/ajpcell.00139.2017 10.1038/s41401-018-0207-3 10.1038/s41581-019-0216-6 10.1007/s11357-019-00095-x 10.1016/j.mehy.2020.110044 10.1016/j.jacc.2003.08.043 10.1002/biof.1399 10.1016/j.yexcr.2018.09.010 10.1016/j.cmet.2014.04.002 10.1161/CIRCULATIONAHA.114.012725 10.1161/CIRCRESAHA.118.313591 10.1038/s41574-021-00626-7 10.1016/j.amjcard.2004.09.013 10.1002/jnr.24397 10.1007/BF03402187 10.3109/10409238.2015.1028612 10.1126/science.aac4854 10.1038/nature02789 10.1038/nature01960 10.1038/nature05354 10.3390/cancers14174162 10.1016/j.ymgme.2011.12.016 10.1002/med.21300 10.1038/s42255-020-00298-z 10.1016/j.jiph.2020.06.004 10.1093/cvr/cvm110 10.1016/j.cell.2020.11.034 10.1016/j.exger.2021.111226 10.1007/s10517-008-0268-2 10.1073/pnas.0712145105 10.1074/jbc.M604370200 10.1194/jlr.S092007 10.1093/nar/gkh215 10.1016/j.bcp.2020.114019 10.1007/s10517-005-0208-3 10.1016/j.cell.2013.06.016 10.1016/j.freeradbiomed.2018.05.073 10.1016/j.cell.2006.11.013 10.3390/ijms232415722 10.1007/978-3-319-09614-8_19 10.1507/endocrj.EJ19-0313 10.1016/j.exger.2020.110888 10.1016/j.cmet.2018.01.016 10.1111/acel.13754 10.1016/j.cmet.2018.02.011 10.1016/j.yexcr.2007.12.012 10.1007/s00395-020-0817-z 10.1016/j.cell.2008.04.019 10.1177/1074248419882002 10.1073/pnas.1016574108 10.1161/CIRCULATIONAHA.116.026099 10.1080/15384101.2019.1640008 10.1124/jpet.115.228643 10.1073/pnas.1505556112 10.1038/s42255-019-0161-5 10.1016/j.cmet.2012.06.016 10.1016/j.cmet.2016.09.013 10.1074/jbc.M805711200 10.2337/db12-0975 10.1371/journal.pone.0186459 10.1016/j.cmet.2018.03.018 10.1016/j.gde.2021.07.005 10.1161/CIRCRESAHA.118.312208 10.1038/s41467-019-12262-x 10.1016/j.cell.2016.07.031 10.1161/ATVBAHA.116.308187 10.1111/acel.12461 10.1124/jpet.108.145938 10.1016/j.cmet.2012.04.003 10.1016/j.celrep.2019.07.043 10.1016/j.cell.2013.11.037 10.1002/biof.1400 10.1016/j.molcel.2007.07.032 10.1016/j.phrs.2010.01.008 10.1007/s12012-016-9387-6 10.1124/jpet.107.120758 10.1172/JCI138538 10.2353/ajpath.2008.080019 10.1042/BSR20202856 10.1155/2017/7543973 10.1016/j.abb.2014.09.008 10.1038/ncomms13103 10.1016/j.cmet.2018.02.001 10.1152/ajpheart.00548.2017 10.1016/j.cmet.2011.03.004 10.1038/s41467-018-03421-7 10.1016/j.bbadis.2015.01.012 10.1016/S0014-5793(99)00913-8 10.1038/s41392-021-00625-0 10.3389/fimmu.2018.01593 10.1111/j.1600-079X.2008.00654.x 10.1007/s11357-020-00165-5 10.1242/jeb.242425 10.1016/j.bbrc.2006.05.042 10.3389/fcvm.2022.881703 10.1016/j.metabol.2021.154733 10.1161/CIR.0000000000000748 10.1002/mnfr.201501019 10.1016/j.redox.2019.101192 10.1093/eurheartj/ehl525 10.1080/15548627.2018.1501132 10.1161/ATVBAHA.114.304794 10.1016/j.jacbts.2022.06.012 10.1038/srep03652 10.1152/ajpheart.00024.2020 10.1016/j.cmet.2016.05.006 10.1124/jpet.116.238261 10.1126/science.aaf2693 10.1016/j.devcel.2008.02.004 10.1161/CIRCULATIONAHA.106.668756 10.1161/HYPERTENSIONAHA.111.183210 10.1016/j.atherosclerosis.2018.01.043 10.15252/embj.201797135 10.34067/KID.0006452020 10.1038/s41591-019-0675-0 10.1038/nrm.2017.53 10.1016/j.semcdb.2016.12.009 10.1016/j.tibs.2006.11.006 10.1097/FJC.0000000000001154 10.1016/j.cmet.2017.11.002 10.1177/1753425915602545 10.1074/jbc.M802187200 10.1161/CIRCRESAHA.109.203703 10.1016/j.bbrc.2003.08.105 10.1016/j.cmet.2011.10.002 10.1530/ERC-13-0171 10.1016/j.bbapap.2016.06.014 10.1016/j.mad.2021.111569 10.1111/nyas.12837 10.1038/nature07813 10.1016/j.neulet.2012.01.007 10.1161/CIRCULATIONAHA.120.046941 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5 10.1038/s42255-018-0009-4 10.3390/ijms22158258 10.1038/s41569-018-0064-2 10.3389/fphar.2018.00266 10.1161/CIRCULATIONAHA.121.056589 10.1016/j.cmet.2011.08.014 10.1016/j.phrs.2020.105125 10.1038/s42255-020-00305-3 |
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Keywords | Nicotinamide adenine dinucleotide Cardiovascular diseases Vascular disorder Atherosclerosis |
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References | von Lukowicz, Hassa, Lohmann, Borén, Braunersreuther, Mach, Odermatt, Gersbach, Camici, Stähli, Tanner, Hottiger, Lüscher, Matter (bib91) 2008; 78 Wang, Airhart, Zhou, Shireman, Jiang, Melendez Rodriguez, Kirkpatrick, Shen, Tian, O'Brien (bib145) 2022; 7 Li, Wang, Li, Li, Tian, Xie, Yang, Jia, He, Gao, Boden, Liu, Yang (bib85) 2016; 6 Miller, Wentzel, Richards (bib152) 2020; 144 Zhang, Zhang, Zhao, Shi, Ye, Tian, Guan, Ying, Qu (bib74) 2020; 115 Bhullar, Hubbard (bib119) 2015; 1852 Howitz, Bitterman, Cohen, Lamming, Lavu, Wood, Zipkin, Chung, Kisielewski, Zhang, Scherer, Sinclair (bib121) 2003; 425 Canner, Furberg, Terrin, McGovern (bib8) 2005; 95 Belenky, Bogan, Brenner (bib13) 2007; 32 Ardanaz, Yang, Cifuentes, Haurani, Jackson, Liao, Carretero, Pagano (bib47) 2010; 55 Zheng, Han, Xia, Shi, Liu, Ying (bib88) 2012; 512 Kiss, Nyúl-Tóth, Balasubramanian, Tarantini, Ahire, Yabluchanskiy, Csipo, Farkas, Wren, Garman, Csiszar, Ungvari (bib55) 2020; 42 Diguet, Trammell, Tannous, Deloux, Piquereau, Mougenot, Gouge, Gressette, Manoury, Blanc, Breton, Decaux, Lavery, Baczkó, Zoll, Garnier, Li, Brenner, Mericskay (bib6) 2018; 137 Pirinen, Cantó, Jo, Morato, Zhang, Menzies, Williams, Mouchiroud, Moullan, Hagberg, Li, Timmers, Imhof, Verbeek, Pujol, van Loon, Viscomi, Zeviani, Schrauwen, Sauve, Schoonjans, Auwerx (bib38) 2014; 19 Hans, Zerfaoui, Naura, Troxclair, Strong, Matrougui, Boulares (bib92) 2009; 329 Mateuszuk, Jasztal, Maslak, Gasior-Glogowska, Baranska, Sitek, Kostogrys, Zakrzewska, Kij, Walczak, Chlopicki (bib83) 2016; 356 Zhai, Han, Wang, Guan, Qu (bib102) 2019; 11 Zong, Gong, Sun, Li, Wang (bib33) 2022; 14 Pacinella, Ciaccio, Tuttolomondo (bib44) 2022; 23 Liaudet, Yang, Al-Affar, Szabó (bib96) 2001; 7 López-Otín, Galluzzi, Freije, Madeo, Kroemer (bib112) 2016; 166 Elhassan, Kluckova, Fletcher, Schmidt, Garten, Doig, Cartwright, Oakey, V Burley, Jenkinson, Wilson, Lucas, Akerman, Seabright, Lai, Tennant, Nightingale, Wallis, Manolopoulos, Brenner, Philp, Lavery (bib144) 2019; 28 Rahman, Helou, Gelzer-Bell, Thompson, Kuo, Rodriguez, Hare, Baughman, Kasper (bib148) 2004; 43 Mouchiroud, Houtkooper, Moullan, Katsyuba, Ryu, Cantó, Mottis, Jo, Viswanathan, Schoonjans, Guarente, Auwerx (bib110) 2013; 154 Liu, Su, Quinn, Hui, Krukenberg, Frederick, Redpath, Zhan, Chellappa, White, Migaud, Mitchison, Baur, Rabinowitz (bib26) 2018; 27 Oumouna-Benachour, Hans, Suzuki, Naura, Datta, Belmadani, Fallon, Woods, Boulares (bib90) 2007; 115 Yoshino, Mills, Yoon, Imai (bib5) 2011; 14 Mallat (bib77) 2014; 34 Ratajczak, Joffraud, Trammell, Ras, Canela, Boutant, Kulkarni, Rodrigues, Redpath, Migaud, Auwerx, Yanes, Brenner, Cantó (bib21) 2016; 7 Rajman, Chwalek, Sinclair (bib10) 2018; 27 Raines, Ganatra, Nissaisorakarn, Pandit, Morales, Asnani, Sadrolashrafi, Maheshwari, Patel, Bang, Shreyder, Brar, Singh, Dani, Knapp, Poyan Mehr, Brown, Zeidel, Bhargava, Schlondorff, Steinman, Mukamal, Parikh (bib154) 2021; 2 Kim, Kim, Lim, Kim, Shin, Park, Kim, Chang, Yoon, Choi (bib136) 2018; 270 Rodriguez-Miguelez, Looney, Thomas, Harshfield, Pollock, Harris (bib28) 2020; 318 Bai, Cantó, Oudart, Brunyánszki, Cen, Thomas, Yamamoto, Huber, Kiss, Houtkooper, Schoonjans, Schreiber, Sauve, Menissier-de Murcia, Auwerx (bib37) 2011; 13 Verdin (bib2) 2015; 350 Xu, Zong, Chen, Jiang, Nan, Li, Duan, Lei, Zhang, Ma, Li, Wang, Wu, Ma, Ma (bib118) 2015; 1348 Yoshida, Satoh, Lin, Mills, Sasaki, Rensing, Wong, Apte, Imai (bib111) 2019; 30 López-Otín, Kroemer (bib113) 2021; 184 Uddin, Farjana, Moni, Hossain, Hannan, Ha (bib135) 2021; 22 Carrico, Meyer, He, Gibson, Verdin (bib27) 2018; 27 Gan, Liu, Liu, Chen, Chen, Liu, Hu, Guan, Ma, Zhang, He, Liu, Tang, Jiang, Xue, Xin (bib105) 2021; 6 Xu, Bai, Little, Liu (bib89) 2014; 34 Jiang, Wang, Song, Liu, Chen, Mu, Xia (bib84) 2016; 60 Klimova, Long, Kristian (bib58) 2019; 97 Boehler, Gauthier, Mortusewicz, Biard, Saliou, Bresson, Sanglier-Cianferani, Smith, Schreiber, Boussin, Dantzer (bib32) 2011; 108 Amici, Young, Narvaez-Miranda, Jablonski, Arcos, Rosas, Papenfuss, Torrelles, Jarjour, Guerau-de-Arellano (bib65) 2018; 9 Grozio, Mills, Yoshino, Bruzzone, Sociali, Tokizane, Lei, Cunningham, Sasaki, Migaud, Imai (bib20) 2019; 1 Mitchell, Bernier, Aon, Cortassa, Kim, Fang, Palacios, Ali, Navas-Enamorado, Di Francesco, Kaiser, Waltz, Zhang, Ellis, Elliott, Frederick, Bohr, Schmidt, Brenner, Sinclair, Sauve, Baur, de Cabo (bib68) 2018; 27 Bermudez, Dahl, Medina, Groeneweg, Holm, Montserrat-de la Paz, Rousch, Otten, Herias, Varela, Ranheim, Yndestad, Ortega-Gomez, Abia, Nagy, Aukrust, Muriana, Halvorsen, Biessen (bib86) 2017; 37 Aomatsu, Takahashi, Sawada, Okubo, Hasegawa, Taira, Miura, Ishisaki, Chosa (bib42) 2014; 4 Sosnowska, Mazidi, Penson, Gluba-Brzózka, Rysz, Banach (bib80) 2017; 265 Fulco, Cen, Zhao, Hoffman, McBurney, Sauve, Sartorelli (bib127) 2008; 14 McReynolds, Chellappa, Baur (bib109) 2020; 134 Strømland, Diab, Ferrario, Sverkeli, Ziegler (bib25) 2021; 199 Cantó, Gerhart-Hines, Feige, Lagouge, Noriega, Milne, Elliott, Puigserver, Auwerx (bib126) 2009; 458 Li, Zhang, Blander, Tse, Krieger, Guarente (bib79) 2007; 28 Chen, Chua, Gao, Chua, Ho, Hamdy, Chua (bib48) 2009; 46 Tarantini, Valcarcel-Ares, Toth, Yabluchanskiy, Tucsek, Kiss, Hertelendy, Kinter, Ballabh, Süle, Farkas, Baur, Sinclair, Csiszar, Ungvari (bib54) 2019; 24 Chini, Peclat, Warner, Kashyap, Espindola-Netto, de Oliveira, Gomez, Hogan, Tarragó, Puranik, Agorrody, Thompson, Dang, Clarke, Childs, Kanamori, Witte, Vidal, Kirkland, De Cecco, Chellappa, McReynolds, Jankowski, Tchkonia, Kirkland, Sedivy, van Deursen, Baker, van Schooten, Rabinowitz, Baur, Chini (bib107) 2020; 2 Vreones, Mustapic, Moaddel, Pucha, Lovett, Seals, Kapogiannis, Martens (bib142) 2023; 22 Graeff, Liu, Kriksunov, Hao, Lee (bib39) 2006; 281 Zhang, Ryu, Wu, Gariani, Wang, Luan, D'Amico, Ropelle, Lutolf, Aebersold, Schoonjans, Menzies, Auwerx (bib106) 2016; 352 Osonoi, Mita, Azuma, Nakajima, Masuyama, Goto, Nishida, Miyatsuka, Fujitani, Koike, Mitsumata, Watada (bib72) 2018; 14 Menzel, Schwarz, Haag, Koch-Nolte (bib23) 2018; 9 de Picciotto, Gano, Johnson, Martens, Sindler, Mills, Imai, Seals (bib52) 2016; 15 Wood, Rogina, Lavu, Howitz, Helfand, Tatar, Sinclair (bib122) 2004; 430 Katsyuba, Romani, Hofer, Auwerx (bib24) 2020; 2 Barger, Kayo, Vann, Arias, Wang, Hacker, Wang, Raederstorff, Morrow, Leeuwenburgh, Allison, Saupe, Cartee, Weindruch, Prolla (bib125) 2008; 3 Lan, Cacicedo, Ruderman, Ido (bib130) 2008; 283 Boslett, Hemann, Christofi, Zweier (bib61) 2018; 314 Baur, Pearson, Price, Jamieson, Lerin, Kalra, V Prabhu, Allard, Lopez-Lluch, Lewis, Pistell, Poosala, Becker, Boss, Gwinn, Wang, Ramaswamy, Fishbein, Spencer, Lakatta, Le Couteur, Shaw, Navas, Puigserver, Ingram, de Cabo, Sinclair (bib123) 2006; 444 LaRocca, Henson, Thorburn, Sindler, Pierce, Seals (bib73) 2012; 590 Chu, Raju (bib9) 2022; 126 Zhou, Wang, Qiu, Airhart, Liu, Stempien-Otero, O'Brien, Tian (bib141) 2020; 130 Rajman, Chwalek, Sinclair (bib12) 2018; 27 Covarrubias, Kale, Perrone, Lopez-Dominguez, Pisco, Kasler, Schmidt, Heckenbach, Kwok, Wiley, Wong, Gibbs, Iyer, Basisty, Wu, Kim, Silva, Vitangcol, Shin, Lee, Riley, Ben-Sahra, Ott, Schilling, Scheibye-Knudsen, Ishihara, Quake, Newman, Brenner, Campisi, Verdin (bib64) 2020; 2 Wolf, Ley (bib76) 2019; 124 Sambeat, Ratajczak, Joffraud, Sanchez-Garcia, Giner, Valsesia, Giroud-Gerbetant, Valera-Alberni, Cercillieux, Boutant, Kulkarni, Moco, Canto (bib7) 2019; 10 Ray Chaudhuri, Nussenzweig (bib18) 2017; 18 Kong, Li, Zhang, Hua, Zhou, Xu, Li, Wang, Miao (bib87) 2019; 40 Mateuszuk, Campagna, Kutryb-Zając, Kuś, Słominska, Smolenski, Chlopicki (bib70) 2020; 178 Zha, Wang, Li, Ma, Yang, Liu (bib93) 2019; 18 Yang, Sauve (bib14) 2016; 1864 Huang, Zhou, Zhang, Huang, Hinojosa-Kirschenbaum, Fan, Yao, Belardinelli, Tellides, Giordano, Budas, Min (bib50) 2015; 131 Testai, Citi, Martelli, Brogi, Calderone (bib56) 2020; 160 Lee, Cao, Mostoslavsky, Lombard, Liu, Bruns, Tsokos, Alt, Finkel (bib75) 2008; 105 Martens, Denman, Mazzo, Armstrong, Reisdorph, McQueen, Chonchol, Seals (bib138) 2018; 9 Misner, Kauss, Singh, Uppal, Bruening-Wright, Liederer, Lin, McCray, La, Nguyen, Sampath, Dragovich, O'Brien, Zabka (bib147) 2017; 17 Liu, Wang, Zhao, Li, Liu, Li, Zhao, Yu, Ji, Shao, Li, Wang, Yang, Hao, Wu, Yuan, Du (bib100) 2023; 165 Furman, Campisi, Verdin, Carrera-Bastos, Targ, Franceschi, Ferrucci, Gilroy, Fasano, Miller, Miller, Mantovani, Weyand, Barzilai, Goronzy, Rando, Effros, Lucia, Kleinstreuer, Slavich (bib63) 2019; 25 Chung, Eckhardt, Chen, Ahmed, Gopinathannair, Joglar, Noseworthy, Pack, Sanders, Trulock (bib1) 2020; 141 Zhang, Wang, Fu, Guan, Han, Zhang, Gan, Fang, Ying, Qu (bib98) 2016; 8 Poulsen, Vestergaard, Clasen, Radko, Christensen, Stødkilde-Jørgensen, Møller, Jessen, Pedersen, Jørgensen (bib134) 2013; 62 Hsu, Oka, Shao, Hariharan, Sadoshima (bib101) 2009; 105 Badawy (bib151) 2020; 40 Auger, Vinaik, Appanna, Jeschke (bib17) 2021; 118 Li, Li, Lin (bib120) 2018; 44 Liao, Zhao, Wang, Zhang, Hao, Hu (bib156) 2021; 18 Kong, Li, Shen, Liu, Zuo, Tao, Ji, Lu, Lazarus, Breyer, Yu (bib69) 2017; 360 Timmers, Konings, Bilet, Houtkooper, van de Weijer, Goossens, Hoeks, van der Krieken, Ryu, Kersten, Moonen-Kornips, Hesselink, Kunz, Schrauwen-Hinderling, Blaak, Auwerx, Schrauwen (bib133) 2011; 14 Caldeira, Santos, Araújo, Lara, Franco, Chaves (bib137) 2021; 146 Weiss, Schilling, Grahnert, Kölling, Dorow, Ceglarek, Sack, Hauschildt (bib67) 2015; 21 Nikiforov, Kulikova, Ziegler (bib11) 2015; 50 Feil, Fehrenbacher, Lukowski, Essmann, Schulze-Osthoff, Schaller, Feil (bib78) 2014; 115 Ralto, Rhee, Parikh (bib22) 2020; 16 Preugschat, Carter, Boros, Porter, Stewart, Shewchuk (bib43) 2014; 564 Vida, Márton, Mikó, Bai (bib35) 2017; 63 V Sukoyan, Andriadze, Guchua, V Karsanov (bib95) 2005; 139 Truong, Jun, Jeong (bib115) 2018; 44 Airhart, Shireman, Risler, Anderson, Nagana Gowda, Raftery, Tian, Shen, O'Brien (bib139) 2017; 12 Oliver, Amé, Roe, Good, de Murcia, Pearl (bib31) 2004; 32 Hou, Xu, Maitland-Toolan, Sato, Jiang, Ido, Lan, Walsh, Wierzbicki, Verbeuren, Cohen, Zang (bib128) 2008; 283 Clerkin, Fri Katsyuba (10.1016/j.athplu.2024.06.001_bib16) 2017; 36 Camacho-Pereira (10.1016/j.athplu.2024.06.001_bib41) 2016; 23 Pacher (10.1016/j.athplu.2024.06.001_bib36) 2008; 173 Carrico (10.1016/j.athplu.2024.06.001_bib27) 2018; 27 Rodriguez-Miguelez (10.1016/j.athplu.2024.06.001_bib28) 2020; 318 Romani (10.1016/j.athplu.2024.06.001_bib146) 2019; 60 Freeberg (10.1016/j.athplu.2024.06.001_bib143) 2022; 9 Canner (10.1016/j.athplu.2024.06.001_bib8) 2005; 95 Belenky (10.1016/j.athplu.2024.06.001_bib13) 2007; 32 Bai (10.1016/j.athplu.2024.06.001_bib37) 2011; 13 Covarrubias (10.1016/j.athplu.2024.06.001_bib64) 2020; 2 von Lukowicz (10.1016/j.athplu.2024.06.001_bib91) 2008; 78 Vida (10.1016/j.athplu.2024.06.001_bib35) 2017; 63 Hu (10.1016/j.athplu.2024.06.001_bib49) 2018; 372 Carter (10.1016/j.athplu.2024.06.001_bib116) 2014; 21 Abdellatif (10.1016/j.athplu.2024.06.001_bib3) 2021; 144 Weiss (10.1016/j.athplu.2024.06.001_bib67) 2015; 21 Mateuszuk (10.1016/j.athplu.2024.06.001_bib70) 2020; 178 McReynolds (10.1016/j.athplu.2024.06.001_bib109) 2020; 134 Vreones (10.1016/j.athplu.2024.06.001_bib142) 2023; 22 Mouchiroud (10.1016/j.athplu.2024.06.001_bib110) 2013; 154 Kong (10.1016/j.athplu.2024.06.001_bib87) 2019; 40 Sambeat (10.1016/j.athplu.2024.06.001_bib7) 2019; 10 Boehler (10.1016/j.athplu.2024.06.001_bib32) 2011; 108 Hsu (10.1016/j.athplu.2024.06.001_bib101) 2009; 105 Badawy (10.1016/j.athplu.2024.06.001_bib151) 2020; 40 Sukhodub (10.1016/j.athplu.2024.06.001_bib103) 2010; 61 Cantó (10.1016/j.athplu.2024.06.001_bib126) 2009; 458 Zhang (10.1016/j.athplu.2024.06.001_bib57) 2017; 2017 Uddin (10.1016/j.athplu.2024.06.001_bib135) 2021; 22 Chung (10.1016/j.athplu.2024.06.001_bib1) 2020; 141 Katsyuba (10.1016/j.athplu.2024.06.001_bib24) 2020; 2 Li (10.1016/j.athplu.2024.06.001_bib79) 2007; 28 Boslett (10.1016/j.athplu.2024.06.001_bib61) 2018; 314 Wang (10.1016/j.athplu.2024.06.001_bib145) 2022; 7 Palazzo (10.1016/j.athplu.2024.06.001_bib34) 2021; 71 Zheng (10.1016/j.athplu.2024.06.001_bib88) 2012; 512 Omran (10.1016/j.athplu.2024.06.001_bib153) 2020; 13 Hosseini (10.1016/j.athplu.2024.06.001_bib104) 2020; 25 Lee (10.1016/j.athplu.2024.06.001_bib75) 2008; 105 Testai (10.1016/j.athplu.2024.06.001_bib56) 2020; 160 Caldeira (10.1016/j.athplu.2024.06.001_bib137) 2021; 146 Amici (10.1016/j.athplu.2024.06.001_bib65) 2018; 9 Graeff (10.1016/j.athplu.2024.06.001_bib39) 2006; 281 Abdellatif (10.1016/j.athplu.2024.06.001_bib71) 2018; 123 Jiang (10.1016/j.athplu.2024.06.001_bib84) 2016; 60 Baur (10.1016/j.athplu.2024.06.001_bib123) 2006; 444 Rajman (10.1016/j.athplu.2024.06.001_bib10) 2018; 27 Misner (10.1016/j.athplu.2024.06.001_bib147) 2017; 17 Bhullar (10.1016/j.athplu.2024.06.001_bib119) 2015; 1852 Wen (10.1016/j.athplu.2024.06.001_bib157) 2021; 224 LaRocca (10.1016/j.athplu.2024.06.001_bib73) 2012; 590 Nikiforov (10.1016/j.athplu.2024.06.001_bib11) 2015; 50 Bai (10.1016/j.athplu.2024.06.001_bib30) 2012; 16 Fulco (10.1016/j.athplu.2024.06.001_bib127) 2008; 14 Lan (10.1016/j.athplu.2024.06.001_bib130) 2008; 283 Zha (10.1016/j.athplu.2024.06.001_bib93) 2019; 18 V Sukoyan (10.1016/j.athplu.2024.06.001_bib94) 2008; 146 Menzel (10.1016/j.athplu.2024.06.001_bib23) 2018; 9 Zhai (10.1016/j.athplu.2024.06.001_bib102) 2019; 11 Trammell (10.1016/j.athplu.2024.06.001_bib140) 2016; 7 Chu (10.1016/j.athplu.2024.06.001_bib9) 2022; 126 Zhou (10.1016/j.athplu.2024.06.001_bib141) 2020; 130 Kiss (10.1016/j.athplu.2024.06.001_bib55) 2020; 42 Rahman (10.1016/j.athplu.2024.06.001_bib148) 2004; 43 Aomatsu (10.1016/j.athplu.2024.06.001_bib42) 2014; 4 Li (10.1016/j.athplu.2024.06.001_bib85) 2016; 6 Li (10.1016/j.athplu.2024.06.001_bib120) 2018; 44 Reyes (10.1016/j.athplu.2024.06.001_bib97) 2015; 112 Pirinen (10.1016/j.athplu.2024.06.001_bib38) 2014; 19 Mallat (10.1016/j.athplu.2024.06.001_bib77) 2014; 34 Sauve (10.1016/j.athplu.2024.06.001_bib15) 2008; 324 Lipphardt (10.1016/j.athplu.2024.06.001_bib29) 2018; 314 Yoshino (10.1016/j.athplu.2024.06.001_bib4) 2018; 27 Auger (10.1016/j.athplu.2024.06.001_bib17) 2021; 118 Zhang (10.1016/j.athplu.2024.06.001_bib74) 2020; 115 Hou (10.1016/j.athplu.2024.06.001_bib128) 2008; 283 López-Otín (10.1016/j.athplu.2024.06.001_bib113) 2021; 184 Mateuszuk (10.1016/j.athplu.2024.06.001_bib83) 2016; 356 Klimova (10.1016/j.athplu.2024.06.001_bib58) 2019; 97 Ray Chaudhuri (10.1016/j.athplu.2024.06.001_bib18) 2017; 18 V Sukoyan (10.1016/j.athplu.2024.06.001_bib95) 2005; 139 Ivanov (10.1016/j.athplu.2024.06.001_bib129) 2008; 314 Bogan (10.1016/j.athplu.2024.06.001_bib19) 2008; 28 Zong (10.1016/j.athplu.2024.06.001_bib33) 2022; 14 Hans (10.1016/j.athplu.2024.06.001_bib92) 2009; 329 Timmers (10.1016/j.athplu.2024.06.001_bib133) 2011; 14 Rajman (10.1016/j.athplu.2024.06.001_bib12) 2018; 27 Ferrucci (10.1016/j.athplu.2024.06.001_bib62) 2018; 15 Barger (10.1016/j.athplu.2024.06.001_bib125) 2008; 3 Strømland (10.1016/j.athplu.2024.06.001_bib25) 2021; 199 Li (10.1016/j.athplu.2024.06.001_bib46) 1995; 11 Yoshida (10.1016/j.athplu.2024.06.001_bib111) 2019; 30 Airhart (10.1016/j.athplu.2024.06.001_bib139) 2017; 12 Miller (10.1016/j.athplu.2024.06.001_bib152) 2020; 144 Yang (10.1016/j.athplu.2024.06.001_bib14) 2016; 1864 Zhang (10.1016/j.athplu.2024.06.001_bib99) 2016; 6 Liu (10.1016/j.athplu.2024.06.001_bib100) 2023; 165 Truong (10.1016/j.athplu.2024.06.001_bib115) 2018; 44 Sosnowska (10.1016/j.athplu.2024.06.001_bib80) 2017; 265 Gomes (10.1016/j.athplu.2024.06.001_bib108) 2013; 155 Kong (10.1016/j.athplu.2024.06.001_bib69) 2017; 360 Osonoi (10.1016/j.athplu.2024.06.001_bib72) 2018; 14 Aksoy (10.1016/j.athplu.2024.06.001_bib60) 2006; 345 Tarantini (10.1016/j.athplu.2024.06.001_bib54) 2019; 24 Begum (10.1016/j.athplu.2024.06.001_bib45) 2021; 78 Howitz (10.1016/j.athplu.2024.06.001_bib121) 2003; 425 Lagouge (10.1016/j.athplu.2024.06.001_bib124) 2006; 127 Oumouna-Benachour (10.1016/j.athplu.2024.06.001_bib90) 2007; 115 Liaudet (10.1016/j.athplu.2024.06.001_bib96) 2001; 7 Chini (10.1016/j.athplu.2024.06.001_bib107) 2020; 2 Kiss (10.1016/j.athplu.2024.06.001_bib59) 2019; 41 Elhassan (10.1016/j.athplu.2024.06.001_bib144) 2019; 28 Amorim (10.1016/j.athplu.2024.06.001_bib51) 2022; 18 Kim (10.1016/j.athplu.2024.06.001_bib136) 2018; 270 Ardanaz (10.1016/j.athplu.2024.06.001_bib47) 2010; 55 de Picciotto (10.1016/j.athplu.2024.06.001_bib52) 2016; 15 Poulsen (10.1016/j.athplu.2024.06.001_bib134) 2013; 62 Diguet (10.1016/j.athplu.2024.06.001_bib6) 2018; 137 Shrotriya (10.1016/j.athplu.2024.06.001_bib117) 2015; 815 Zhang (10.1016/j.athplu.2024.06.001_bib98) 2016; 8 Xu (10.1016/j.athplu.2024.06.001_bib118) 2015; 1348 Martens (10.1016/j.athplu.2024.06.001_bib138) 2018; 9 Pacinella (10.1016/j.athplu.2024.06.001_bib44) 2022; 23 Leonard (10.1016/j.athplu.2024.06.001_bib114) 2003; 309 Liu (10.1016/j.athplu.2024.06.001_bib26) 2018; 27 Mills (10.1016/j.athplu.2024.06.001_bib155) 2016; 24 Preugschat (10.1016/j.athplu.2024.06.001_bib43) 2014; 564 Clerkin (10.1016/j.athplu.2024.06.001_bib150) 2020; 141 Furman (10.1016/j.athplu.2024.06.001_bib63) 2019; 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34 Ralto (10.1016/j.athplu.2024.06.001_bib22) 2020; 16 Irie (10.1016/j.athplu.2024.06.001_bib158) 2020; 67 López-Otín (10.1016/j.athplu.2024.06.001_bib112) 2016; 166 Feil (10.1016/j.athplu.2024.06.001_bib78) 2014; 115 Méndez-Lara (10.1016/j.athplu.2024.06.001_bib81) 2020; 9 Ratajczak (10.1016/j.athplu.2024.06.001_bib21) 2016; 7 Oliver (10.1016/j.athplu.2024.06.001_bib31) 2004; 32 Polzonetti (10.1016/j.athplu.2024.06.001_bib66) 2012; 105 Wood (10.1016/j.athplu.2024.06.001_bib122) 2004; 430 |
References_xml | – volume: 329 start-page: 150 year: 2009 end-page: 158 ident: bib92 article-title: Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content publication-title: J Pharmacol Exp Ther contributor: fullname: Boulares – volume: 2 start-page: 9 year: 2020 end-page: 31 ident: bib24 article-title: NAD(+) homeostasis in health and disease publication-title: Nat Metab contributor: fullname: Auwerx – volume: 281 start-page: 28951 year: 2006 end-page: 28957 ident: bib39 article-title: Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities publication-title: J Biol Chem contributor: fullname: Lee – volume: 139 start-page: 46 year: 2005 end-page: 49 ident: bib95 article-title: Effect of NAD on recovery of adenine nucleotide pool, phosphorylation potential, and stimulation of apoptosis during late period of reperfusion damage to myocardium publication-title: Bull Exp Biol Med contributor: fullname: V Karsanov – volume: 118 year: 2021 ident: bib17 article-title: Beyond mitochondria: alternative energy-producing pathways from all strata of life publication-title: Metabolism contributor: fullname: Jeschke – volume: 18 start-page: 243 year: 2022 end-page: 258 ident: bib51 article-title: Mitochondrial and metabolic dysfunction in ageing and age-related diseases publication-title: Nat Rev Endocrinol contributor: fullname: Sinclair – volume: 166 start-page: 802 year: 2016 end-page: 821 ident: bib112 article-title: Metabolic control of longevity publication-title: Cell contributor: fullname: Kroemer – volume: 105 start-page: 481 year: 2009 end-page: 491 ident: bib101 article-title: Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes publication-title: Circ Res contributor: fullname: Sadoshima – volume: 115 start-page: 662 year: 2014 end-page: 667 ident: bib78 article-title: Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis publication-title: Circ Res contributor: fullname: Feil – volume: 115 start-page: 2442 year: 2007 end-page: 2450 ident: bib90 article-title: Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death publication-title: Circulation contributor: fullname: Boulares – volume: 127 start-page: 1109 year: 2006 end-page: 1122 ident: bib124 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha publication-title: Cell contributor: fullname: Auwerx – volume: 12 year: 2017 ident: bib139 article-title: An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers publication-title: PLoS One contributor: fullname: O'Brien – volume: 24 start-page: 795 year: 2016 end-page: 806 ident: bib155 article-title: Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice publication-title: Cell Metab contributor: fullname: Imai – volume: 14 year: 2022 ident: bib33 article-title: PARP1: liaison of chromatin remodeling and transcription publication-title: Cancers contributor: fullname: Wang – volume: 17 start-page: 307 year: 2017 end-page: 318 ident: bib147 article-title: Cardiotoxicity associated with nicotinamide phosphoribosyltransferase inhibitors in rodents and in rat and human-derived cells lines publication-title: Cardiovasc Toxicol contributor: fullname: Zabka – volume: 16 start-page: 99 year: 2020 end-page: 111 ident: bib22 article-title: NAD(+) homeostasis in renal health and disease publication-title: Nat Rev Nephrol contributor: fullname: Parikh – volume: 8 start-page: 3342 year: 2016 end-page: 3350 ident: bib98 article-title: Exogenous NAD(+) administration significantly protects against myocardial ischemia/reperfusion injury in rat model publication-title: Am J Transl Res contributor: fullname: Qu – volume: 22 year: 2021 ident: bib135 article-title: Prospective pharmacological potential of resveratrol in delaying kidney aging publication-title: Int J Mol Sci contributor: fullname: Ha – volume: 37 start-page: 1157 year: 2017 end-page: 1167 ident: bib86 article-title: Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPAR$γ$-Dependent monocyte differentiation and function publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Biessen – volume: 146 year: 2021 ident: bib137 article-title: Resveratrol: change of SIRT 1 and AMPK signaling pattern during the aging process publication-title: Exp Gerontol contributor: fullname: Chaves – volume: 154 start-page: 430 year: 2013 end-page: 441 ident: bib110 article-title: The NAD(+)/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling publication-title: Cell contributor: fullname: Auwerx – volume: 425 start-page: 191 year: 2003 end-page: 196 ident: bib121 article-title: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan publication-title: Nature contributor: fullname: Sinclair – volume: 318 start-page: H1371 year: 2020 end-page: H1378 ident: bib28 article-title: Sirt1 during childhood is associated with microvascular function later in life publication-title: Am J Physiol Heart Circ Physiol contributor: fullname: Harris – volume: 14 start-page: 1991 year: 2018 end-page: 2006 ident: bib72 article-title: Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis publication-title: Autophagy contributor: fullname: Watada – volume: 25 start-page: 240 year: 2020 end-page: 250 ident: bib104 article-title: Melatonin and nicotinamide mononucleotide attenuate myocardial ischemia/reperfusion injury via modulation of mitochondrial function and hemodynamic parameters in aged rats publication-title: J Cardiovasc Pharmacol Ther contributor: fullname: Badalzadeh – volume: 95 start-page: 254 year: 2005 end-page: 257 ident: bib8 article-title: Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project) publication-title: Am J Cardiol contributor: fullname: McGovern – volume: 199 year: 2021 ident: bib25 article-title: The balance between NAD(+) biosynthesis and consumption in ageing publication-title: Mech Ageing Dev contributor: fullname: Ziegler – volume: 41 start-page: 419 year: 2019 end-page: 439 ident: bib59 article-title: Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects publication-title: GeroScience contributor: fullname: Ungvari – volume: 356 start-page: 514 year: 2016 end-page: 524 ident: bib83 article-title: Antiatherosclerotic effects of 1-methylnicotinamide in apolipoprotein E/low-density lipoprotein receptor-deficient mice: a comparison with nicotinic acid publication-title: J Pharmacol Exp Ther contributor: fullname: Chlopicki – volume: 9 year: 2022 ident: bib143 article-title: Nicotinamide riboside supplementation for treating elevated systolic blood pressure and arterial stiffness in midlife and older adults publication-title: Front Cardiovasc Med contributor: fullname: Seals – volume: 34 start-page: 2509 year: 2014 end-page: 2519 ident: bib77 article-title: Macrophages publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Mallat – volume: 126 year: 2022 ident: bib9 article-title: Regulation of NAD(+) metabolism in aging and disease publication-title: Metabolism contributor: fullname: Raju – volume: 1348 start-page: 10 year: 2015 end-page: 19 ident: bib118 article-title: Resveratrol in the treatment of pancreatic cancer publication-title: Ann N Y Acad Sci contributor: fullname: Ma – volume: 24 year: 2019 ident: bib54 article-title: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice publication-title: Redox Biol contributor: fullname: Ungvari – volume: 360 start-page: 435 year: 2017 end-page: 444 ident: bib69 article-title: Niacin promotes cardiac healing after myocardial infarction through activation of the myeloid prostaglandin D(2) receptor subtype 1 publication-title: J Pharmacol Exp Ther contributor: fullname: Yu – volume: 105 start-page: 502 year: 2012 end-page: 507 ident: bib66 article-title: Population variability in CD38 activity: correlation with age and significant effect of TNF-α -308G>A and CD38 184C>G SNPs publication-title: Mol Genet Metab contributor: fullname: Napolioni – volume: 115 start-page: 57 year: 2020 ident: bib74 article-title: NAD(+) administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux publication-title: Basic Res Cardiol contributor: fullname: Qu – volume: 112 start-page: 11648 year: 2015 end-page: 11653 ident: bib97 article-title: Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart publication-title: Proc Natl Acad Sci U S A contributor: fullname: Zweier – volume: 512 start-page: 67 year: 2012 end-page: 71 ident: bib88 article-title: NAD(+) administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia publication-title: Neurosci Lett contributor: fullname: Ying – volume: 131 start-page: 1082 year: 2015 end-page: 1097 ident: bib50 article-title: Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function publication-title: Circulation contributor: fullname: Min – volume: 6 year: 2016 ident: bib99 article-title: Reciprocal changes of circulating long non-coding RNAs ZFAS1 and CDR1AS predict acute myocardial infarction publication-title: Sci Rep contributor: fullname: Yang – volume: 350 start-page: 1208 year: 2015 end-page: 1213 ident: bib2 article-title: NAD publication-title: Science contributor: fullname: Verdin – volume: 14 start-page: 612 year: 2011 end-page: 622 ident: bib133 article-title: Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans publication-title: Cell Metab contributor: fullname: Schrauwen – volume: 352 start-page: 1436 year: 2016 end-page: 1443 ident: bib106 article-title: NAD publication-title: Science contributor: fullname: Auwerx – volume: 25 start-page: 1822 year: 2019 end-page: 1832 ident: bib63 article-title: Chronic inflammation in the etiology of disease across the life span publication-title: Nat Med contributor: fullname: Slavich – volume: 18 start-page: 54 year: 2021 ident: bib156 article-title: Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study publication-title: J Int Soc Sports Nutr contributor: fullname: Hu – volume: 32 start-page: 456 year: 2004 end-page: 464 ident: bib31 article-title: Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2 publication-title: Nucleic Acids Res contributor: fullname: Pearl – volume: 40 year: 2020 ident: bib151 article-title: Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide publication-title: Biosci Rep contributor: fullname: Badawy – volume: 11 start-page: 376 year: 1995 end-page: 381 ident: bib46 article-title: Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase publication-title: Nat Genet contributor: fullname: Epstein – volume: 314 start-page: 1163 year: 2008 end-page: 1176 ident: bib129 article-title: Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression publication-title: Exp Cell Res contributor: fullname: Hei – volume: 155 start-page: 1624 year: 2013 end-page: 1638 ident: bib108 article-title: Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging publication-title: Cell contributor: fullname: Sinclair – volume: 46 start-page: 235 year: 2009 end-page: 241 ident: bib48 article-title: Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1 publication-title: J Pineal Res contributor: fullname: Chua – volume: 430 start-page: 686 year: 2004 end-page: 689 ident: bib122 article-title: Sirtuin activators mimic caloric restriction and delay ageing in metazoans publication-title: Nature contributor: fullname: Sinclair – volume: 78 start-page: 158 year: 2008 end-page: 166 ident: bib91 article-title: PARP1 is required for adhesion molecule expression in atherogenesis publication-title: Cardiovasc Res contributor: fullname: Matter – volume: 7 year: 2016 ident: bib140 article-title: Nicotinamide riboside is uniquely and orally bioavailable in mice and humans publication-title: Nat Commun contributor: fullname: Brenner – volume: 15 start-page: 522 year: 2016 end-page: 530 ident: bib52 article-title: Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice publication-title: Aging Cell contributor: fullname: Seals – volume: 3 year: 2008 ident: bib125 article-title: A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice publication-title: PLoS One contributor: fullname: Prolla – volume: 28 start-page: 733 year: 2007 end-page: 740 ident: bib149 article-title: Myocarditis in hypertrophic cardiomyopathy patients presenting acute clinical deterioration publication-title: Eur Heart J contributor: fullname: Chimenti – volume: 108 start-page: 2783 year: 2011 end-page: 2788 ident: bib32 article-title: Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression publication-title: Proc Natl Acad Sci USA contributor: fullname: Dantzer – volume: 18 start-page: 2099 year: 2019 end-page: 2109 ident: bib93 article-title: PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis publication-title: Cell Cycle contributor: fullname: Liu – volume: 815 start-page: 333 year: 2015 end-page: 348 ident: bib117 article-title: A perspective on chemoprevention by resveratrol in head and neck squamous cell carcinoma publication-title: Adv Exp Med Biol contributor: fullname: Sclafani – volume: 372 start-page: 61 year: 2018 end-page: 72 ident: bib49 article-title: Loss of thioredoxin 2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy publication-title: Exp Cell Res contributor: fullname: Yang – volume: 1 start-page: 47 year: 2019 end-page: 57 ident: bib20 article-title: Slc12a8 is a nicotinamide mononucleotide transporter publication-title: Nat Metab contributor: fullname: Imai – volume: 324 start-page: 883 year: 2008 end-page: 893 ident: bib15 article-title: NAD+ and vitamin B3: from metabolism to therapies publication-title: J Pharmacol Exp Therapeut contributor: fullname: Sauve – volume: 144 start-page: 1795 year: 2021 end-page: 1817 ident: bib3 article-title: NAD(+) metabolism in cardiac health, aging, and disease publication-title: Circulation contributor: fullname: Kroemer – volume: 590 start-page: 3305 year: 2012 end-page: 3316 ident: bib73 article-title: Translational evidence that impaired autophagy contributes to arterial ageing publication-title: J Physiol contributor: fullname: Seals – volume: 105 start-page: 3374 year: 2008 end-page: 3379 ident: bib75 article-title: A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy publication-title: Proc Natl Acad Sci U S A contributor: fullname: Finkel – volume: 43 start-page: 410 year: 2004 end-page: 415 ident: bib148 article-title: Noninvasive diagnosis of biopsy-proven cardiac amyloidosis publication-title: J Am Coll Cardiol contributor: fullname: Kasper – volume: 23 start-page: 1127 year: 2016 end-page: 1139 ident: bib41 article-title: CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism publication-title: Cell Metab contributor: fullname: Chini – volume: 144 year: 2020 ident: bib152 article-title: COVID-19: NAD(+) deficiency may predispose the aged, obese and type 2 diabetics to mortality through its effect on SIRT1 activity publication-title: Med Hypotheses contributor: fullname: Richards – volume: 97 start-page: 975 year: 2019 end-page: 990 ident: bib58 article-title: Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice publication-title: J Neurosci Res contributor: fullname: Kristian – volume: 133 start-page: 387 year: 2008 end-page: 391 ident: bib132 article-title: Xenohormesis: sensing the chemical cues of other species publication-title: Cell contributor: fullname: Sinclair – volume: 62 start-page: 1186 year: 2013 end-page: 1195 ident: bib134 article-title: High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition publication-title: Diabetes contributor: fullname: Jørgensen – volume: 36 start-page: 2670 year: 2017 end-page: 2683 ident: bib16 article-title: Modulating NAD(+) metabolism, from bench to bedside publication-title: EMBO J contributor: fullname: Auwerx – volume: 9 start-page: 1593 year: 2018 ident: bib65 article-title: CD38 is robustly induced in human macrophages and monocytes in inflammatory conditions publication-title: Front Immunol contributor: fullname: Guerau-de-Arellano – volume: 6 year: 2016 ident: bib85 article-title: NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance publication-title: Sci Rep contributor: fullname: Yang – volume: 42 start-page: 527 year: 2020 end-page: 546 ident: bib55 article-title: Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects publication-title: GeroScience contributor: fullname: Ungvari – volume: 283 start-page: 20015 year: 2008 end-page: 20026 ident: bib128 article-title: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase publication-title: J Biol Chem contributor: fullname: Zang – volume: 444 start-page: 337 year: 2006 end-page: 342 ident: bib123 article-title: Resveratrol improves health and survival of mice on a high-calorie diet publication-title: Nature contributor: fullname: Sinclair – volume: 44 start-page: 69 year: 2018 end-page: 82 ident: bib120 article-title: Effect of resveratrol and pterostilbene on aging and longevity publication-title: Biofactors contributor: fullname: Lin – volume: 2 start-page: 33 year: 2021 end-page: 41 ident: bib154 article-title: Niacinamide may Be associated with improved outcomes in COVID-19-related acute kidney injury: an observational study publication-title: Kidney360 contributor: fullname: Parikh – volume: 1864 start-page: 1787 year: 2016 end-page: 1800 ident: bib14 article-title: NAD(+) metabolism: bioenergetics, signaling and manipulation for therapy publication-title: Biochim Biophys Acta contributor: fullname: Sauve – volume: 2017 year: 2017 ident: bib57 article-title: Sirt1 inhibits oxidative stress in vascular endothelial cells publication-title: Oxid Med Cell Longev contributor: fullname: Chen – volume: 22 year: 2023 ident: bib142 article-title: Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin publication-title: Aging Cell contributor: fullname: Martens – volume: 9 year: 2020 ident: bib81 article-title: Nicotinamide prevents apolipoprotein B-containing lipoprotein oxidation, inflammation and atherosclerosis in apolipoprotein E-deficient mice publication-title: Antioxidants (Basel, Switzerland) contributor: fullname: Julve – volume: 60 start-page: 741 year: 2019 end-page: 746 ident: bib146 article-title: Niacin: an old lipid drug in a new NAD(+) dress publication-title: J Lipid Res contributor: fullname: Auwerx – volume: 50 start-page: 284 year: 2015 end-page: 297 ident: bib11 article-title: The human NAD metabolome: functions, metabolism and compartmentalization publication-title: Crit Rev Biochem Mol Biol contributor: fullname: Ziegler – volume: 7 year: 2016 ident: bib21 article-title: NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells publication-title: Nat Commun contributor: fullname: Cantó – volume: 27 start-page: 529 year: 2018 end-page: 547 ident: bib12 article-title: Therapeutic potential of NAD-boosting molecules: the in vivo evidence publication-title: Cell Metabol contributor: fullname: Sinclair – volume: 178 year: 2020 ident: bib70 article-title: Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside publication-title: Biochem Pharmacol contributor: fullname: Chlopicki – volume: 2 start-page: 1284 year: 2020 end-page: 1304 ident: bib107 article-title: CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels publication-title: Nat Metab contributor: fullname: Chini – volume: 345 start-page: 1386 year: 2006 end-page: 1392 ident: bib60 article-title: Regulation of intracellular levels of NAD: a novel role for CD38 publication-title: Biochem Biophys Res Commun contributor: fullname: Chini – volume: 7 start-page: 406 year: 2001 end-page: 417 ident: bib96 article-title: Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase publication-title: Mol Med contributor: fullname: Szabó – volume: 1852 start-page: 1209 year: 2015 end-page: 1218 ident: bib119 article-title: Lifespan and healthspan extension by resveratrol publication-title: Biochim Biophys Acta contributor: fullname: Hubbard – volume: 270 start-page: 123 year: 2018 end-page: 131 ident: bib136 article-title: The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system publication-title: Atherosclerosis contributor: fullname: Choi – volume: 59 start-page: 825 year: 2012 end-page: 832 ident: bib82 article-title: Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels publication-title: Hypertens (Dallas, Tex 1979) contributor: fullname: Kalinowski – volume: 173 start-page: 2 year: 2008 end-page: 13 ident: bib36 article-title: Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease publication-title: Am J Pathol contributor: fullname: Szabo – volume: 165 year: 2023 ident: bib100 article-title: CDR1as promotes arrhythmias in myocardial infarction via targeting the NAMPT-NAD(+) pathway publication-title: Biomed {\&} Pharmacother = Biomed {\&} Pharmacother contributor: fullname: Du – volume: 23 year: 2022 ident: bib44 article-title: Endothelial dysfunction and chronic inflammation: the cornerstones of vascular alterations in age-related diseases publication-title: Int J Mol Sci contributor: fullname: Tuttolomondo – volume: 11 start-page: 6066 year: 2019 end-page: 6074 ident: bib102 article-title: Exogenous supplemental NAD+ protect myocardium against myocardial ischemic/reperfusion injury in swine model publication-title: Am J Transl Res contributor: fullname: Qu – volume: 6 start-page: 223 year: 2021 ident: bib105 article-title: CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice publication-title: Signal Transduct Target Ther contributor: fullname: Xin – volume: 141 start-page: e750 year: 2020 end-page: e772 ident: bib1 article-title: Lifestyle and risk factor modification for reduction of atrial fibrillation: a scientific statement from the American heart association publication-title: Circulation contributor: fullname: Trulock – volume: 9 start-page: 266 year: 2018 ident: bib23 article-title: Nanobody-based biologics for modulating purinergic signaling in inflammation and immunity publication-title: Front Pharmacol contributor: fullname: Koch-Nolte – volume: 134 year: 2020 ident: bib109 article-title: Age-related NAD(+) decline publication-title: Exp Gerontol contributor: fullname: Baur – volume: 309 start-page: 1017 year: 2003 end-page: 1026 ident: bib114 article-title: Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses publication-title: Biochem Biophys Res Commun contributor: fullname: Shi – volume: 19 start-page: 1034 year: 2014 end-page: 1041 ident: bib38 article-title: Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle publication-title: Cell Metab contributor: fullname: Auwerx – volume: 21 start-page: 813 year: 2015 end-page: 826 ident: bib67 article-title: Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features publication-title: Innate Immun contributor: fullname: Hauschildt – volume: 124 start-page: 315 year: 2019 end-page: 327 ident: bib76 article-title: Immunity and inflammation in atherosclerosis publication-title: Circ Res contributor: fullname: Ley – volume: 130 start-page: 6054 year: 2020 end-page: 6063 ident: bib141 article-title: Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure publication-title: J Clin Invest contributor: fullname: Tian – volume: 14 start-page: 661 year: 2008 end-page: 673 ident: bib127 article-title: Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt publication-title: Dev Cell contributor: fullname: Sartorelli – volume: 283 start-page: 27628 year: 2008 end-page: 27635 ident: bib130 article-title: SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation publication-title: J Biol Chem contributor: fullname: Ido – volume: 123 start-page: 803 year: 2018 end-page: 824 ident: bib71 article-title: Autophagy in cardiovascular aging publication-title: Circ Res contributor: fullname: Kroemer – volume: 184 start-page: 33 year: 2021 end-page: 63 ident: bib113 article-title: Hallmarks of health publication-title: Cell contributor: fullname: Kroemer – volume: 2 start-page: 1265 year: 2020 end-page: 1283 ident: bib64 article-title: Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages publication-title: Nat Metab contributor: fullname: Verdin – volume: 21 year: 2014 ident: bib116 article-title: Resveratrol and cancer: focus on in vivo evidence publication-title: Endocr Relat Cancer contributor: fullname: Pearson – volume: 458 start-page: 1056 year: 2009 end-page: 1060 ident: bib126 article-title: AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity publication-title: Nature contributor: fullname: Auwerx – volume: 141 start-page: 1648 year: 2020 end-page: 1655 ident: bib150 article-title: COVID-19 and cardiovascular disease publication-title: Circulation contributor: fullname: Uriel – volume: 265 start-page: 275 year: 2017 end-page: 282 ident: bib80 article-title: The sirtuin family members SIRT1, SIRT3 and SIRT6: their role in vascular biology and atherogenesis publication-title: Atherosclerosis contributor: fullname: Banach – volume: 32 start-page: 12 year: 2007 end-page: 19 ident: bib13 article-title: NAD+ metabolism in health and disease publication-title: Trends Biochem Sci contributor: fullname: Brenner – volume: 27 start-page: 513 year: 2018 end-page: 528 ident: bib4 article-title: NAD(+) intermediates: the biology and therapeutic potential of NMN and NR publication-title: Cell Metabol contributor: fullname: Imai – volume: 9 start-page: 1286 year: 2018 ident: bib138 article-title: Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults publication-title: Nat Commun contributor: fullname: Seals – volume: 137 start-page: 2256 year: 2018 end-page: 2273 ident: bib6 article-title: Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy publication-title: Circulation contributor: fullname: Mericskay – volume: 27 start-page: 1067 year: 2018 end-page: 1080 ident: bib26 article-title: Quantitative analysis of NAD synthesis-breakdown fluxes publication-title: Cell Metabol contributor: fullname: Rabinowitz – volume: 34 start-page: 644 year: 2014 end-page: 675 ident: bib89 article-title: Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications publication-title: Med Res Rev contributor: fullname: Liu – volume: 40 start-page: 1184 year: 2019 end-page: 1192 ident: bib87 article-title: Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice publication-title: Acta Pharmacol Sin contributor: fullname: Miao – volume: 146 start-page: 321 year: 2008 end-page: 324 ident: bib94 article-title: Effect of nadcin on energy supply system and apoptosis in ischemia-reperfusion injury to the myocardium publication-title: Bull Exp Biol Med contributor: fullname: Kavadze – volume: 13 start-page: 1196 year: 2020 end-page: 1201 ident: bib153 article-title: Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: a hypothesis publication-title: J Infect Public Health contributor: fullname: Almaliki – volume: 123 start-page: 125 year: 2018 end-page: 137 ident: bib53 article-title: Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis publication-title: Free Radic Biol {\&} Med contributor: fullname: Peng – volume: 61 start-page: 564 year: 2010 end-page: 570 ident: bib103 article-title: Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A publication-title: Pharmacol Res contributor: fullname: Jovanović – volume: 71 start-page: 106 year: 2021 end-page: 113 ident: bib34 article-title: Serine ADP-ribosylation in DNA-damage response regulation publication-title: Curr Opin Genet {\&} Dev contributor: fullname: Ahel – volume: 314 start-page: C297 year: 2018 end-page: C309 ident: bib61 article-title: Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion publication-title: Am J Physiol Cell Physiol contributor: fullname: Zweier – volume: 63 start-page: 135 year: 2017 end-page: 143 ident: bib35 article-title: Metabolic roles of poly(ADP-ribose) polymerases publication-title: Semin Cell {\&} Dev Biol contributor: fullname: Bai – volume: 27 start-page: 529 year: 2018 end-page: 547 ident: bib10 article-title: Therapeutic potential of NAD-boosting molecules: the in vivo evidence publication-title: Cell Metabol contributor: fullname: Sinclair – volume: 28 start-page: 91 year: 2007 end-page: 106 ident: bib79 article-title: SIRT1 deacetylates and positively regulates the nuclear receptor LXR publication-title: Mol Cell contributor: fullname: Guarente – volume: 60 start-page: 1625 year: 2016 end-page: 1636 ident: bib84 article-title: N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice publication-title: Mol Nutr {\&} Food Res contributor: fullname: Xia – volume: 7 start-page: 1183 year: 2022 end-page: 1196 ident: bib145 article-title: Safety and tolerability of nicotinamide riboside in heart failure with reduced ejection fraction publication-title: JACC Basic to Transl Sci contributor: fullname: O'Brien – volume: 30 start-page: 329 year: 2019 end-page: 342 ident: bib111 article-title: Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice publication-title: Cell Metab contributor: fullname: Imai – volume: 44 start-page: 36 year: 2018 end-page: 49 ident: bib115 article-title: Role of resveratrol in regulation of cellular defense systems against oxidative stress publication-title: Biofactors contributor: fullname: Jeong – volume: 67 start-page: 153 year: 2020 end-page: 160 ident: bib158 article-title: Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men publication-title: Endocr J contributor: fullname: Itoh – volume: 15 start-page: 675 year: 2012 end-page: 690 ident: bib131 article-title: SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function publication-title: Cell Metab contributor: fullname: Sinclair – volume: 78 start-page: S63 year: 2021 end-page: S77 ident: bib45 article-title: Endothelial SIRT1 as a target for the prevention of arterial aging: promises and challenges publication-title: J Cardiovasc Pharmacol contributor: fullname: Wang – volume: 14 start-page: 528 year: 2011 end-page: 536 ident: bib5 article-title: Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice publication-title: Cell Metabol contributor: fullname: Imai – volume: 13 start-page: 461 year: 2011 end-page: 468 ident: bib37 article-title: PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation publication-title: Cell Metab contributor: fullname: Auwerx – volume: 27 start-page: 497 year: 2018 end-page: 512 ident: bib27 article-title: The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications publication-title: Cell Metabol contributor: fullname: Verdin – volume: 18 start-page: 610 year: 2017 end-page: 621 ident: bib18 article-title: The multifaceted roles of PARP1 in DNA repair and chromatin remodelling publication-title: Nat Rev Mol Cell Biol contributor: fullname: Nussenzweig – volume: 4 start-page: 3652 year: 2014 ident: bib42 article-title: Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells publication-title: Sci Rep contributor: fullname: Chosa – volume: 314 start-page: H484 year: 2018 end-page: H496 ident: bib29 article-title: Endothelial dysfunction is a superinducer of syndecan-4: fibrogenic role of its ectodomain publication-title: Am J Physiol Heart Circ Physiol contributor: fullname: Goligorsky – volume: 10 start-page: 4291 year: 2019 ident: bib7 article-title: Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage publication-title: Nat Commun contributor: fullname: Canto – volume: 455 start-page: 359 year: 1999 end-page: 363 ident: bib40 article-title: Hydrolysis of NADP+ by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2’-phosphate publication-title: FEBS Lett contributor: fullname: Balduini – volume: 160 year: 2020 ident: bib56 article-title: Role of hydrogen sulfide in cardiovascular ageing publication-title: Pharmacol Res contributor: fullname: Calderone – volume: 15 start-page: 505 year: 2018 end-page: 522 ident: bib62 article-title: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty publication-title: Nat Rev Cardiol contributor: fullname: Fabbri – volume: 28 start-page: 1717 year: 2019 end-page: 1728.e6 ident: bib144 article-title: Nicotinamide riboside augments the aged human skeletal muscle NAD(+) metabolome and induces transcriptomic and anti-inflammatory signatures publication-title: Cell Rep contributor: fullname: Lavery – volume: 27 start-page: 667 year: 2018 end-page: 676 ident: bib68 article-title: Nicotinamide improves aspects of healthspan, but not lifespan, in mice publication-title: Cell Metab contributor: fullname: de Cabo – volume: 564 start-page: 156 year: 2014 end-page: 163 ident: bib43 article-title: A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157 publication-title: Arch Biochem Biophys contributor: fullname: Shewchuk – volume: 55 start-page: 116 year: 2010 end-page: 123 ident: bib47 article-title: Lack of glutathione peroxidase 1 accelerates cardiac-specific hypertrophy and dysfunction in angiotensin II hypertension publication-title: Hypertens (Dallas, Tex 1979 contributor: fullname: Pagano – volume: 224 year: 2021 ident: bib157 article-title: Activation of cardiac Nmnat/NAD+/SIR2 pathways mediates endurance exercise resistance to lipotoxic cardiomyopathy in aging Drosophila publication-title: J Exp Biol contributor: fullname: Hou – volume: 28 start-page: 115 year: 2008 end-page: 130 ident: bib19 article-title: Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition publication-title: Annu Rev Nutr contributor: fullname: Brenner – volume: 16 start-page: 290 year: 2012 end-page: 295 ident: bib30 article-title: The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease publication-title: Cell Metabol contributor: fullname: Cantó – volume: 7 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib140 article-title: Nicotinamide riboside is uniquely and orally bioavailable in mice and humans publication-title: Nat Commun doi: 10.1038/ncomms12948 contributor: fullname: Trammell – volume: 18 start-page: 54 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib156 article-title: Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study publication-title: J Int Soc Sports Nutr doi: 10.1186/s12970-021-00442-4 contributor: fullname: Liao – volume: 590 start-page: 3305 year: 2012 ident: 10.1016/j.athplu.2024.06.001_bib73 article-title: Translational evidence that impaired autophagy contributes to arterial ageing publication-title: J Physiol doi: 10.1113/jphysiol.2012.229690 contributor: fullname: LaRocca – volume: 30 start-page: 329 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib111 article-title: Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice publication-title: Cell Metab doi: 10.1016/j.cmet.2019.05.015 contributor: fullname: Yoshida – volume: 28 start-page: 115 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib19 article-title: Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition publication-title: Annu Rev Nutr doi: 10.1146/annurev.nutr.28.061807.155443 contributor: fullname: Bogan – volume: 11 start-page: 376 year: 1995 ident: 10.1016/j.athplu.2024.06.001_bib46 article-title: Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase publication-title: Nat Genet doi: 10.1038/ng1295-376 contributor: fullname: Li – volume: 115 start-page: 662 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib78 article-title: Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis publication-title: Circ Res doi: 10.1161/CIRCRESAHA.115.304634 contributor: fullname: Feil – volume: 126 year: 2022 ident: 10.1016/j.athplu.2024.06.001_bib9 article-title: Regulation of NAD(+) metabolism in aging and disease publication-title: Metabolism doi: 10.1016/j.metabol.2021.154923 contributor: fullname: Chu – volume: 265 start-page: 275 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib80 article-title: The sirtuin family members SIRT1, SIRT3 and SIRT6: their role in vascular biology and atherogenesis publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2017.08.027 contributor: fullname: Sosnowska – volume: 314 start-page: C297 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib61 article-title: Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia-reoxygenation triggering NAD(P)H depletion publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00139.2017 contributor: fullname: Boslett – volume: 40 start-page: 1184 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib87 article-title: Nicotinamide phosphoribosyltransferase aggravates inflammation and promotes atherosclerosis in ApoE knockout mice publication-title: Acta Pharmacol Sin doi: 10.1038/s41401-018-0207-3 contributor: fullname: Kong – volume: 16 start-page: 99 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib22 article-title: NAD(+) homeostasis in renal health and disease publication-title: Nat Rev Nephrol doi: 10.1038/s41581-019-0216-6 contributor: fullname: Ralto – volume: 41 start-page: 419 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib59 article-title: Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects publication-title: GeroScience doi: 10.1007/s11357-019-00095-x contributor: fullname: Kiss – volume: 144 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib152 article-title: COVID-19: NAD(+) deficiency may predispose the aged, obese and type 2 diabetics to mortality through its effect on SIRT1 activity publication-title: Med Hypotheses doi: 10.1016/j.mehy.2020.110044 contributor: fullname: Miller – volume: 43 start-page: 410 year: 2004 ident: 10.1016/j.athplu.2024.06.001_bib148 article-title: Noninvasive diagnosis of biopsy-proven cardiac amyloidosis publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2003.08.043 contributor: fullname: Rahman – volume: 44 start-page: 36 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib115 article-title: Role of resveratrol in regulation of cellular defense systems against oxidative stress publication-title: Biofactors doi: 10.1002/biof.1399 contributor: fullname: Truong – volume: 372 start-page: 61 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib49 article-title: Loss of thioredoxin 2 alters mitochondrial respiratory function and induces cardiomyocyte hypertrophy publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2018.09.010 contributor: fullname: Hu – volume: 19 start-page: 1034 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib38 article-title: Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle publication-title: Cell Metab doi: 10.1016/j.cmet.2014.04.002 contributor: fullname: Pirinen – volume: 131 start-page: 1082 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib50 article-title: Thioredoxin-2 inhibits mitochondrial reactive oxygen species generation and apoptosis stress kinase-1 activity to maintain cardiac function publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.114.012725 contributor: fullname: Huang – volume: 124 start-page: 315 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib76 article-title: Immunity and inflammation in atherosclerosis publication-title: Circ Res doi: 10.1161/CIRCRESAHA.118.313591 contributor: fullname: Wolf – volume: 18 start-page: 243 year: 2022 ident: 10.1016/j.athplu.2024.06.001_bib51 article-title: Mitochondrial and metabolic dysfunction in ageing and age-related diseases publication-title: Nat Rev Endocrinol doi: 10.1038/s41574-021-00626-7 contributor: fullname: Amorim – volume: 95 start-page: 254 year: 2005 ident: 10.1016/j.athplu.2024.06.001_bib8 article-title: Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project) publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2004.09.013 contributor: fullname: Canner – volume: 97 start-page: 975 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib58 article-title: Nicotinamide mononucleotide alters mitochondrial dynamics by SIRT3-dependent mechanism in male mice publication-title: J Neurosci Res doi: 10.1002/jnr.24397 contributor: fullname: Klimova – volume: 7 start-page: 406 year: 2001 ident: 10.1016/j.athplu.2024.06.001_bib96 article-title: Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase publication-title: Mol Med doi: 10.1007/BF03402187 contributor: fullname: Liaudet – volume: 50 start-page: 284 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib11 article-title: The human NAD metabolome: functions, metabolism and compartmentalization publication-title: Crit Rev Biochem Mol Biol doi: 10.3109/10409238.2015.1028612 contributor: fullname: Nikiforov – volume: 350 start-page: 1208 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib2 article-title: NAD+ in aging, metabolism, and neurodegeneration publication-title: Science doi: 10.1126/science.aac4854 contributor: fullname: Verdin – volume: 430 start-page: 686 year: 2004 ident: 10.1016/j.athplu.2024.06.001_bib122 article-title: Sirtuin activators mimic caloric restriction and delay ageing in metazoans publication-title: Nature doi: 10.1038/nature02789 contributor: fullname: Wood – volume: 425 start-page: 191 year: 2003 ident: 10.1016/j.athplu.2024.06.001_bib121 article-title: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan publication-title: Nature doi: 10.1038/nature01960 contributor: fullname: Howitz – volume: 55 start-page: 116 year: 2010 ident: 10.1016/j.athplu.2024.06.001_bib47 article-title: Lack of glutathione peroxidase 1 accelerates cardiac-specific hypertrophy and dysfunction in angiotensin II hypertension publication-title: Hypertens (Dallas, Tex 1979 contributor: fullname: Ardanaz – volume: 444 start-page: 337 year: 2006 ident: 10.1016/j.athplu.2024.06.001_bib123 article-title: Resveratrol improves health and survival of mice on a high-calorie diet publication-title: Nature doi: 10.1038/nature05354 contributor: fullname: Baur – volume: 14 year: 2022 ident: 10.1016/j.athplu.2024.06.001_bib33 article-title: PARP1: liaison of chromatin remodeling and transcription publication-title: Cancers doi: 10.3390/cancers14174162 contributor: fullname: Zong – volume: 105 start-page: 502 year: 2012 ident: 10.1016/j.athplu.2024.06.001_bib66 article-title: Population variability in CD38 activity: correlation with age and significant effect of TNF-α -308G>A and CD38 184C>G SNPs publication-title: Mol Genet Metab doi: 10.1016/j.ymgme.2011.12.016 contributor: fullname: Polzonetti – volume: 34 start-page: 644 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib89 article-title: Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications publication-title: Med Res Rev doi: 10.1002/med.21300 contributor: fullname: Xu – volume: 2 start-page: 1284 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib107 article-title: CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels publication-title: Nat Metab doi: 10.1038/s42255-020-00298-z contributor: fullname: Chini – volume: 13 start-page: 1196 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib153 article-title: Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: a hypothesis publication-title: J Infect Public Health doi: 10.1016/j.jiph.2020.06.004 contributor: fullname: Omran – volume: 78 start-page: 158 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib91 article-title: PARP1 is required for adhesion molecule expression in atherogenesis publication-title: Cardiovasc Res doi: 10.1093/cvr/cvm110 contributor: fullname: von Lukowicz – volume: 184 start-page: 33 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib113 article-title: Hallmarks of health publication-title: Cell doi: 10.1016/j.cell.2020.11.034 contributor: fullname: López-Otín – volume: 146 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib137 article-title: Resveratrol: change of SIRT 1 and AMPK signaling pattern during the aging process publication-title: Exp Gerontol doi: 10.1016/j.exger.2021.111226 contributor: fullname: Caldeira – volume: 146 start-page: 321 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib94 article-title: Effect of nadcin on energy supply system and apoptosis in ischemia-reperfusion injury to the myocardium publication-title: Bull Exp Biol Med doi: 10.1007/s10517-008-0268-2 contributor: fullname: V Sukoyan – volume: 105 start-page: 3374 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib75 article-title: A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0712145105 contributor: fullname: Lee – volume: 281 start-page: 28951 year: 2006 ident: 10.1016/j.athplu.2024.06.001_bib39 article-title: Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities publication-title: J Biol Chem doi: 10.1074/jbc.M604370200 contributor: fullname: Graeff – volume: 6 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib99 article-title: Reciprocal changes of circulating long non-coding RNAs ZFAS1 and CDR1AS predict acute myocardial infarction publication-title: Sci Rep contributor: fullname: Zhang – volume: 165 year: 2023 ident: 10.1016/j.athplu.2024.06.001_bib100 article-title: CDR1as promotes arrhythmias in myocardial infarction via targeting the NAMPT-NAD(+) pathway publication-title: Biomed {\&} Pharmacother = Biomed {\&} Pharmacother contributor: fullname: Liu – volume: 60 start-page: 741 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib146 article-title: Niacin: an old lipid drug in a new NAD(+) dress publication-title: J Lipid Res doi: 10.1194/jlr.S092007 contributor: fullname: Romani – volume: 32 start-page: 456 year: 2004 ident: 10.1016/j.athplu.2024.06.001_bib31 article-title: Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkh215 contributor: fullname: Oliver – volume: 178 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib70 article-title: Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2020.114019 contributor: fullname: Mateuszuk – volume: 139 start-page: 46 year: 2005 ident: 10.1016/j.athplu.2024.06.001_bib95 article-title: Effect of NAD on recovery of adenine nucleotide pool, phosphorylation potential, and stimulation of apoptosis during late period of reperfusion damage to myocardium publication-title: Bull Exp Biol Med doi: 10.1007/s10517-005-0208-3 contributor: fullname: V Sukoyan – volume: 154 start-page: 430 year: 2013 ident: 10.1016/j.athplu.2024.06.001_bib110 article-title: The NAD(+)/Sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling publication-title: Cell doi: 10.1016/j.cell.2013.06.016 contributor: fullname: Mouchiroud – volume: 123 start-page: 125 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib53 article-title: Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis publication-title: Free Radic Biol {\&} Med doi: 10.1016/j.freeradbiomed.2018.05.073 contributor: fullname: Hong – volume: 127 start-page: 1109 year: 2006 ident: 10.1016/j.athplu.2024.06.001_bib124 article-title: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1 alpha publication-title: Cell doi: 10.1016/j.cell.2006.11.013 contributor: fullname: Lagouge – volume: 23 year: 2022 ident: 10.1016/j.athplu.2024.06.001_bib44 article-title: Endothelial dysfunction and chronic inflammation: the cornerstones of vascular alterations in age-related diseases publication-title: Int J Mol Sci doi: 10.3390/ijms232415722 contributor: fullname: Pacinella – volume: 815 start-page: 333 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib117 article-title: A perspective on chemoprevention by resveratrol in head and neck squamous cell carcinoma publication-title: Adv Exp Med Biol doi: 10.1007/978-3-319-09614-8_19 contributor: fullname: Shrotriya – volume: 67 start-page: 153 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib158 article-title: Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men publication-title: Endocr J doi: 10.1507/endocrj.EJ19-0313 contributor: fullname: Irie – volume: 134 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib109 article-title: Age-related NAD(+) decline publication-title: Exp Gerontol doi: 10.1016/j.exger.2020.110888 contributor: fullname: McReynolds – volume: 27 start-page: 497 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib27 article-title: The mitochondrial acylome emerges: proteomics, regulation by sirtuins, and metabolic and disease implications publication-title: Cell Metabol doi: 10.1016/j.cmet.2018.01.016 contributor: fullname: Carrico – volume: 22 year: 2023 ident: 10.1016/j.athplu.2024.06.001_bib142 article-title: Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin publication-title: Aging Cell doi: 10.1111/acel.13754 contributor: fullname: Vreones – volume: 27 start-page: 529 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib12 article-title: Therapeutic potential of NAD-boosting molecules: the in vivo evidence publication-title: Cell Metabol doi: 10.1016/j.cmet.2018.02.011 contributor: fullname: Rajman – volume: 314 start-page: 1163 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib129 article-title: Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2007.12.012 contributor: fullname: Ivanov – volume: 115 start-page: 57 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib74 article-title: NAD(+) administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux publication-title: Basic Res Cardiol doi: 10.1007/s00395-020-0817-z contributor: fullname: Zhang – volume: 133 start-page: 387 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib132 article-title: Xenohormesis: sensing the chemical cues of other species publication-title: Cell doi: 10.1016/j.cell.2008.04.019 contributor: fullname: Howitz – volume: 25 start-page: 240 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib104 article-title: Melatonin and nicotinamide mononucleotide attenuate myocardial ischemia/reperfusion injury via modulation of mitochondrial function and hemodynamic parameters in aged rats publication-title: J Cardiovasc Pharmacol Ther doi: 10.1177/1074248419882002 contributor: fullname: Hosseini – volume: 108 start-page: 2783 year: 2011 ident: 10.1016/j.athplu.2024.06.001_bib32 article-title: Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1016574108 contributor: fullname: Boehler – volume: 137 start-page: 2256 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib6 article-title: Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.116.026099 contributor: fullname: Diguet – volume: 18 start-page: 2099 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib93 article-title: PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis publication-title: Cell Cycle doi: 10.1080/15384101.2019.1640008 contributor: fullname: Zha – volume: 356 start-page: 514 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib83 article-title: Antiatherosclerotic effects of 1-methylnicotinamide in apolipoprotein E/low-density lipoprotein receptor-deficient mice: a comparison with nicotinic acid publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.115.228643 contributor: fullname: Mateuszuk – volume: 112 start-page: 11648 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib97 article-title: Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1505556112 contributor: fullname: Reyes – volume: 2 start-page: 9 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib24 article-title: NAD(+) homeostasis in health and disease publication-title: Nat Metab doi: 10.1038/s42255-019-0161-5 contributor: fullname: Katsyuba – volume: 16 start-page: 290 year: 2012 ident: 10.1016/j.athplu.2024.06.001_bib30 article-title: The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease publication-title: Cell Metabol doi: 10.1016/j.cmet.2012.06.016 contributor: fullname: Bai – volume: 24 start-page: 795 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib155 article-title: Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice publication-title: Cell Metab doi: 10.1016/j.cmet.2016.09.013 contributor: fullname: Mills – volume: 283 start-page: 27628 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib130 article-title: SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation publication-title: J Biol Chem doi: 10.1074/jbc.M805711200 contributor: fullname: Lan – volume: 62 start-page: 1186 year: 2013 ident: 10.1016/j.athplu.2024.06.001_bib134 article-title: High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition publication-title: Diabetes doi: 10.2337/db12-0975 contributor: fullname: Poulsen – volume: 12 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib139 article-title: An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers publication-title: PLoS One doi: 10.1371/journal.pone.0186459 contributor: fullname: Airhart – volume: 27 start-page: 1067 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib26 article-title: Quantitative analysis of NAD synthesis-breakdown fluxes publication-title: Cell Metabol doi: 10.1016/j.cmet.2018.03.018 contributor: fullname: Liu – volume: 71 start-page: 106 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib34 article-title: Serine ADP-ribosylation in DNA-damage response regulation publication-title: Curr Opin Genet {\&} Dev doi: 10.1016/j.gde.2021.07.005 contributor: fullname: Palazzo – volume: 123 start-page: 803 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib71 article-title: Autophagy in cardiovascular aging publication-title: Circ Res doi: 10.1161/CIRCRESAHA.118.312208 contributor: fullname: Abdellatif – volume: 10 start-page: 4291 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib7 article-title: Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage publication-title: Nat Commun doi: 10.1038/s41467-019-12262-x contributor: fullname: Sambeat – volume: 166 start-page: 802 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib112 article-title: Metabolic control of longevity publication-title: Cell doi: 10.1016/j.cell.2016.07.031 contributor: fullname: López-Otín – volume: 37 start-page: 1157 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib86 article-title: Leukocyte overexpression of intracellular NAMPT attenuates atherosclerosis by regulating PPAR$γ$-Dependent monocyte differentiation and function publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.116.308187 contributor: fullname: Bermudez – volume: 15 start-page: 522 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib52 article-title: Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice publication-title: Aging Cell doi: 10.1111/acel.12461 contributor: fullname: de Picciotto – volume: 329 start-page: 150 year: 2009 ident: 10.1016/j.athplu.2024.06.001_bib92 article-title: Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.108.145938 contributor: fullname: Hans – volume: 15 start-page: 675 year: 2012 ident: 10.1016/j.athplu.2024.06.001_bib131 article-title: SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function publication-title: Cell Metab doi: 10.1016/j.cmet.2012.04.003 contributor: fullname: Price – volume: 28 start-page: 1717 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib144 article-title: Nicotinamide riboside augments the aged human skeletal muscle NAD(+) metabolome and induces transcriptomic and anti-inflammatory signatures publication-title: Cell Rep doi: 10.1016/j.celrep.2019.07.043 contributor: fullname: Elhassan – volume: 155 start-page: 1624 year: 2013 ident: 10.1016/j.athplu.2024.06.001_bib108 article-title: Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging publication-title: Cell doi: 10.1016/j.cell.2013.11.037 contributor: fullname: Gomes – volume: 44 start-page: 69 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib120 article-title: Effect of resveratrol and pterostilbene on aging and longevity publication-title: Biofactors doi: 10.1002/biof.1400 contributor: fullname: Li – volume: 28 start-page: 91 year: 2007 ident: 10.1016/j.athplu.2024.06.001_bib79 article-title: SIRT1 deacetylates and positively regulates the nuclear receptor LXR publication-title: Mol Cell doi: 10.1016/j.molcel.2007.07.032 contributor: fullname: Li – volume: 61 start-page: 564 year: 2010 ident: 10.1016/j.athplu.2024.06.001_bib103 article-title: Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A publication-title: Pharmacol Res doi: 10.1016/j.phrs.2010.01.008 contributor: fullname: Sukhodub – volume: 17 start-page: 307 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib147 article-title: Cardiotoxicity associated with nicotinamide phosphoribosyltransferase inhibitors in rodents and in rat and human-derived cells lines publication-title: Cardiovasc Toxicol doi: 10.1007/s12012-016-9387-6 contributor: fullname: Misner – volume: 324 start-page: 883 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib15 article-title: NAD+ and vitamin B3: from metabolism to therapies publication-title: J Pharmacol Exp Therapeut doi: 10.1124/jpet.107.120758 contributor: fullname: Sauve – volume: 130 start-page: 6054 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib141 article-title: Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure publication-title: J Clin Invest doi: 10.1172/JCI138538 contributor: fullname: Zhou – volume: 173 start-page: 2 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib36 article-title: Role of the peroxynitrite-poly(ADP-ribose) polymerase pathway in human disease publication-title: Am J Pathol doi: 10.2353/ajpath.2008.080019 contributor: fullname: Pacher – volume: 40 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib151 article-title: Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide publication-title: Biosci Rep doi: 10.1042/BSR20202856 contributor: fullname: Badawy – volume: 2017 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib57 article-title: Sirt1 inhibits oxidative stress in vascular endothelial cells publication-title: Oxid Med Cell Longev doi: 10.1155/2017/7543973 contributor: fullname: Zhang – volume: 564 start-page: 156 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib43 article-title: A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157 publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2014.09.008 contributor: fullname: Preugschat – volume: 9 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib81 article-title: Nicotinamide prevents apolipoprotein B-containing lipoprotein oxidation, inflammation and atherosclerosis in apolipoprotein E-deficient mice publication-title: Antioxidants (Basel, Switzerland) contributor: fullname: Méndez-Lara – volume: 7 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib21 article-title: NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells publication-title: Nat Commun doi: 10.1038/ncomms13103 contributor: fullname: Ratajczak – volume: 27 start-page: 667 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib68 article-title: Nicotinamide improves aspects of healthspan, but not lifespan, in mice publication-title: Cell Metab doi: 10.1016/j.cmet.2018.02.001 contributor: fullname: Mitchell – volume: 314 start-page: H484 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib29 article-title: Endothelial dysfunction is a superinducer of syndecan-4: fibrogenic role of its ectodomain publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00548.2017 contributor: fullname: Lipphardt – volume: 13 start-page: 461 year: 2011 ident: 10.1016/j.athplu.2024.06.001_bib37 article-title: PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation publication-title: Cell Metab doi: 10.1016/j.cmet.2011.03.004 contributor: fullname: Bai – volume: 6 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib85 article-title: NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance publication-title: Sci Rep contributor: fullname: Li – volume: 9 start-page: 1286 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib138 article-title: Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults publication-title: Nat Commun doi: 10.1038/s41467-018-03421-7 contributor: fullname: Martens – volume: 1852 start-page: 1209 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib119 article-title: Lifespan and healthspan extension by resveratrol publication-title: Biochim Biophys Acta doi: 10.1016/j.bbadis.2015.01.012 contributor: fullname: Bhullar – volume: 455 start-page: 359 year: 1999 ident: 10.1016/j.athplu.2024.06.001_bib40 article-title: Hydrolysis of NADP+ by platelet CD38 in the absence of synthesis and degradation of cyclic ADP-ribose 2’-phosphate publication-title: FEBS Lett doi: 10.1016/S0014-5793(99)00913-8 contributor: fullname: Torti – volume: 6 start-page: 223 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib105 article-title: CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice publication-title: Signal Transduct Target Ther doi: 10.1038/s41392-021-00625-0 contributor: fullname: Gan – volume: 9 start-page: 1593 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib65 article-title: CD38 is robustly induced in human macrophages and monocytes in inflammatory conditions publication-title: Front Immunol doi: 10.3389/fimmu.2018.01593 contributor: fullname: Amici – volume: 46 start-page: 235 year: 2009 ident: 10.1016/j.athplu.2024.06.001_bib48 article-title: Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1 publication-title: J Pineal Res doi: 10.1111/j.1600-079X.2008.00654.x contributor: fullname: Chen – volume: 42 start-page: 527 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib55 article-title: Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects publication-title: GeroScience doi: 10.1007/s11357-020-00165-5 contributor: fullname: Kiss – volume: 224 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib157 article-title: Activation of cardiac Nmnat/NAD+/SIR2 pathways mediates endurance exercise resistance to lipotoxic cardiomyopathy in aging Drosophila publication-title: J Exp Biol doi: 10.1242/jeb.242425 contributor: fullname: Wen – volume: 8 start-page: 3342 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib98 article-title: Exogenous NAD(+) administration significantly protects against myocardial ischemia/reperfusion injury in rat model publication-title: Am J Transl Res contributor: fullname: Zhang – volume: 345 start-page: 1386 year: 2006 ident: 10.1016/j.athplu.2024.06.001_bib60 article-title: Regulation of intracellular levels of NAD: a novel role for CD38 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2006.05.042 contributor: fullname: Aksoy – volume: 9 year: 2022 ident: 10.1016/j.athplu.2024.06.001_bib143 article-title: Nicotinamide riboside supplementation for treating elevated systolic blood pressure and arterial stiffness in midlife and older adults publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2022.881703 contributor: fullname: Freeberg – volume: 118 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib17 article-title: Beyond mitochondria: alternative energy-producing pathways from all strata of life publication-title: Metabolism doi: 10.1016/j.metabol.2021.154733 contributor: fullname: Auger – volume: 141 start-page: e750 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib1 article-title: Lifestyle and risk factor modification for reduction of atrial fibrillation: a scientific statement from the American heart association publication-title: Circulation doi: 10.1161/CIR.0000000000000748 contributor: fullname: Chung – volume: 60 start-page: 1625 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib84 article-title: N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice publication-title: Mol Nutr {\&} Food Res doi: 10.1002/mnfr.201501019 contributor: fullname: Jiang – volume: 24 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib54 article-title: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice publication-title: Redox Biol doi: 10.1016/j.redox.2019.101192 contributor: fullname: Tarantini – volume: 28 start-page: 733 year: 2007 ident: 10.1016/j.athplu.2024.06.001_bib149 article-title: Myocarditis in hypertrophic cardiomyopathy patients presenting acute clinical deterioration publication-title: Eur Heart J doi: 10.1093/eurheartj/ehl525 contributor: fullname: Frustaci – volume: 14 start-page: 1991 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib72 article-title: Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis publication-title: Autophagy doi: 10.1080/15548627.2018.1501132 contributor: fullname: Osonoi – volume: 34 start-page: 2509 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib77 article-title: Macrophages publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.114.304794 contributor: fullname: Mallat – volume: 7 start-page: 1183 year: 2022 ident: 10.1016/j.athplu.2024.06.001_bib145 article-title: Safety and tolerability of nicotinamide riboside in heart failure with reduced ejection fraction publication-title: JACC Basic to Transl Sci doi: 10.1016/j.jacbts.2022.06.012 contributor: fullname: Wang – volume: 4 start-page: 3652 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib42 article-title: Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells publication-title: Sci Rep doi: 10.1038/srep03652 contributor: fullname: Aomatsu – volume: 318 start-page: H1371 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib28 article-title: Sirt1 during childhood is associated with microvascular function later in life publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00024.2020 contributor: fullname: Rodriguez-Miguelez – volume: 23 start-page: 1127 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib41 article-title: CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism publication-title: Cell Metab doi: 10.1016/j.cmet.2016.05.006 contributor: fullname: Camacho-Pereira – volume: 360 start-page: 435 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib69 article-title: Niacin promotes cardiac healing after myocardial infarction through activation of the myeloid prostaglandin D(2) receptor subtype 1 publication-title: J Pharmacol Exp Ther doi: 10.1124/jpet.116.238261 contributor: fullname: Kong – volume: 352 start-page: 1436 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib106 article-title: NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice publication-title: Science doi: 10.1126/science.aaf2693 contributor: fullname: Zhang – volume: 14 start-page: 661 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib127 article-title: Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt publication-title: Dev Cell doi: 10.1016/j.devcel.2008.02.004 contributor: fullname: Fulco – volume: 115 start-page: 2442 year: 2007 ident: 10.1016/j.athplu.2024.06.001_bib90 article-title: Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.668756 contributor: fullname: Oumouna-Benachour – volume: 59 start-page: 825 year: 2012 ident: 10.1016/j.athplu.2024.06.001_bib82 article-title: Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels publication-title: Hypertens (Dallas, Tex 1979) doi: 10.1161/HYPERTENSIONAHA.111.183210 contributor: fullname: Domagala – volume: 270 start-page: 123 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib136 article-title: The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2018.01.043 contributor: fullname: Kim – volume: 36 start-page: 2670 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib16 article-title: Modulating NAD(+) metabolism, from bench to bedside publication-title: EMBO J doi: 10.15252/embj.201797135 contributor: fullname: Katsyuba – volume: 2 start-page: 33 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib154 article-title: Niacinamide may Be associated with improved outcomes in COVID-19-related acute kidney injury: an observational study publication-title: Kidney360 doi: 10.34067/KID.0006452020 contributor: fullname: Raines – volume: 25 start-page: 1822 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib63 article-title: Chronic inflammation in the etiology of disease across the life span publication-title: Nat Med doi: 10.1038/s41591-019-0675-0 contributor: fullname: Furman – volume: 18 start-page: 610 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib18 article-title: The multifaceted roles of PARP1 in DNA repair and chromatin remodelling publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm.2017.53 contributor: fullname: Ray Chaudhuri – volume: 63 start-page: 135 year: 2017 ident: 10.1016/j.athplu.2024.06.001_bib35 article-title: Metabolic roles of poly(ADP-ribose) polymerases publication-title: Semin Cell {\&} Dev Biol doi: 10.1016/j.semcdb.2016.12.009 contributor: fullname: Vida – volume: 32 start-page: 12 year: 2007 ident: 10.1016/j.athplu.2024.06.001_bib13 article-title: NAD+ metabolism in health and disease publication-title: Trends Biochem Sci doi: 10.1016/j.tibs.2006.11.006 contributor: fullname: Belenky – volume: 78 start-page: S63 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib45 article-title: Endothelial SIRT1 as a target for the prevention of arterial aging: promises and challenges publication-title: J Cardiovasc Pharmacol doi: 10.1097/FJC.0000000000001154 contributor: fullname: Begum – volume: 27 start-page: 513 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib4 article-title: NAD(+) intermediates: the biology and therapeutic potential of NMN and NR publication-title: Cell Metabol doi: 10.1016/j.cmet.2017.11.002 contributor: fullname: Yoshino – volume: 21 start-page: 813 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib67 article-title: Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features publication-title: Innate Immun doi: 10.1177/1753425915602545 contributor: fullname: Weiss – volume: 283 start-page: 20015 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib128 article-title: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase publication-title: J Biol Chem doi: 10.1074/jbc.M802187200 contributor: fullname: Hou – volume: 105 start-page: 481 year: 2009 ident: 10.1016/j.athplu.2024.06.001_bib101 article-title: Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes publication-title: Circ Res doi: 10.1161/CIRCRESAHA.109.203703 contributor: fullname: Hsu – volume: 309 start-page: 1017 year: 2003 ident: 10.1016/j.athplu.2024.06.001_bib114 article-title: Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2003.08.105 contributor: fullname: Leonard – volume: 14 start-page: 612 year: 2011 ident: 10.1016/j.athplu.2024.06.001_bib133 article-title: Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans publication-title: Cell Metab doi: 10.1016/j.cmet.2011.10.002 contributor: fullname: Timmers – volume: 21 year: 2014 ident: 10.1016/j.athplu.2024.06.001_bib116 article-title: Resveratrol and cancer: focus on in vivo evidence publication-title: Endocr Relat Cancer doi: 10.1530/ERC-13-0171 contributor: fullname: Carter – volume: 1864 start-page: 1787 year: 2016 ident: 10.1016/j.athplu.2024.06.001_bib14 article-title: NAD(+) metabolism: bioenergetics, signaling and manipulation for therapy publication-title: Biochim Biophys Acta doi: 10.1016/j.bbapap.2016.06.014 contributor: fullname: Yang – volume: 199 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib25 article-title: The balance between NAD(+) biosynthesis and consumption in ageing publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2021.111569 contributor: fullname: Strømland – volume: 1348 start-page: 10 year: 2015 ident: 10.1016/j.athplu.2024.06.001_bib118 article-title: Resveratrol in the treatment of pancreatic cancer publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.12837 contributor: fullname: Xu – volume: 458 start-page: 1056 year: 2009 ident: 10.1016/j.athplu.2024.06.001_bib126 article-title: AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity publication-title: Nature doi: 10.1038/nature07813 contributor: fullname: Cantó – volume: 512 start-page: 67 year: 2012 ident: 10.1016/j.athplu.2024.06.001_bib88 article-title: NAD(+) administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia publication-title: Neurosci Lett doi: 10.1016/j.neulet.2012.01.007 contributor: fullname: Zheng – volume: 141 start-page: 1648 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib150 article-title: COVID-19 and cardiovascular disease publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.046941 contributor: fullname: Clerkin – volume: 3 year: 2008 ident: 10.1016/j.athplu.2024.06.001_bib125 article-title: A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice publication-title: PLoS One doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5 contributor: fullname: Barger – volume: 1 start-page: 47 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib20 article-title: Slc12a8 is a nicotinamide mononucleotide transporter publication-title: Nat Metab doi: 10.1038/s42255-018-0009-4 contributor: fullname: Grozio – volume: 22 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib135 article-title: Prospective pharmacological potential of resveratrol in delaying kidney aging publication-title: Int J Mol Sci doi: 10.3390/ijms22158258 contributor: fullname: Uddin – volume: 15 start-page: 505 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib62 article-title: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty publication-title: Nat Rev Cardiol doi: 10.1038/s41569-018-0064-2 contributor: fullname: Ferrucci – volume: 11 start-page: 6066 year: 2019 ident: 10.1016/j.athplu.2024.06.001_bib102 article-title: Exogenous supplemental NAD+ protect myocardium against myocardial ischemic/reperfusion injury in swine model publication-title: Am J Transl Res contributor: fullname: Zhai – volume: 9 start-page: 266 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib23 article-title: Nanobody-based biologics for modulating purinergic signaling in inflammation and immunity publication-title: Front Pharmacol doi: 10.3389/fphar.2018.00266 contributor: fullname: Menzel – volume: 144 start-page: 1795 year: 2021 ident: 10.1016/j.athplu.2024.06.001_bib3 article-title: NAD(+) metabolism in cardiac health, aging, and disease publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.121.056589 contributor: fullname: Abdellatif – volume: 14 start-page: 528 year: 2011 ident: 10.1016/j.athplu.2024.06.001_bib5 article-title: Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice publication-title: Cell Metabol doi: 10.1016/j.cmet.2011.08.014 contributor: fullname: Yoshino – volume: 160 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib56 article-title: Role of hydrogen sulfide in cardiovascular ageing publication-title: Pharmacol Res doi: 10.1016/j.phrs.2020.105125 contributor: fullname: Testai – volume: 2 start-page: 1265 year: 2020 ident: 10.1016/j.athplu.2024.06.001_bib64 article-title: Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages publication-title: Nat Metab doi: 10.1038/s42255-020-00305-3 contributor: fullname: Covarrubias – volume: 27 start-page: 529 year: 2018 ident: 10.1016/j.athplu.2024.06.001_bib10 article-title: Therapeutic potential of NAD-boosting molecules: the in vivo evidence publication-title: Cell Metabol doi: 10.1016/j.cmet.2018.02.011 contributor: fullname: Rajman |
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