Initial Experience of Metabolic Imaging With Hyperpolarized [1‐13C]pyruvate MRI in Kidney Transplant Patients

• Published in: Journal of magnetic resonance imaging Vol. 61; no. 4; pp. 1969 - 1978
• Main Authors: Liu, Xiaoxi, Lai, Ying‐Chieh, Cui, Di, Kung, Shiang‐Cheng, Park, Meyeon, Laszik, Zoltan, Larson, Peder E. Z., Wang, Zhen J.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2025; Wiley Subscription Services, Inc
• Subjects: [1‐13C]lactate; [1‐13C]pyruvate; Adult; Allografts; Allografts - diagnostic imaging; Biopsy; Carbon Isotopes - chemistry; Carcinoma, Renal Cell - diagnostic imaging; Carcinoma, Renal Cell - metabolism; Creatine; Damage prevention; Diffusion rate; Epidermal growth factor receptors; Feasibility Studies; Female; Females; Fibrosis; Field strength; Glomerular Filtration Rate; Humans; hyperpolarized 13C; Injury prevention; Kidney - diagnostic imaging; Kidney - metabolism; Kidney cancer; Kidney Neoplasms - diagnostic imaging; Kidney Neoplasms - metabolism; kidney transplant; Kidney Transplantation; Kidney transplants; Kidneys; Lactic acid; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Mean; Medical imaging; Metabolism; Metabolites; Microvasculature; Middle Aged; Prospective Studies; Pyruvic acid; Pyruvic Acid - chemistry; Pyruvic Acid - metabolism; Renal cell carcinoma; Statistical analysis; Statistical tests; Tumors; [1‐13C]pyruvate; hyperpolarized 13C; kidney transplant; [1‐13C]lactate

Background Kidney transplant is the treatment of choice for patients with end‐stage renal disease. Early detection of allograft injury is important to delay or prevent irreversible damage. Purpose To investigate the feasibility of hyperpolarized (HP) [1‐13C]pyruvate MRI for assessing kidney allograf...